|Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis|
KL Walton, KE Johnson, CA Harrison
Frontiers in pharmacology 8, 461, 2017
|Elevated expression of activins promotes muscle wasting and cachexia|
JL Chen, KL Walton, CE Winbanks, KT Murphy, RE Thomson, Y Makanji, ...
The FASEB Journal 28 (4), 1711-1723, 2014
|Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands|
CA Harrison, SL Al-Musawi, KL Walton
Growth factors 29 (5), 174-186, 2011
|Structural basis for potency differences between GDF8 and GDF11|
RG Walker, M Czepnik, EJ Goebel, JC McCoy, A Vujic, M Cho, J Oh, ...
BMC biology 15, 1-22, 2017
|Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease|
JL Chen, KL Walton, A Hagg, TD Colgan, K Johnson, H Qian, ...
Proceedings of the National Academy of Sciences 114 (26), E5266-E5275, 2017
|New insights into the mechanisms of activin action and inhibition|
KL Walton, Y Makanji, CA Harrison
Molecular and cellular endocrinology 359 (1-2), 2-12, 2012
|Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-β1 complex|
KL Walton, Y Makanji, J Chen, MC Wilce, KL Chan, DM Robertson, ...
Journal of Biological Chemistry 285 (22), 17029-17037, 2010
|A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor β (TGFβ) ligands|
KL Walton, Y Makanji, MC Wilce, KL Chan, DM Robertson, CA Harrison
Journal of Biological Chemistry 284 (14), 9311-9320, 2009
|Hormonal regulation of sertoli cell micro-RNAs at spermiation|
PK Nicholls, CA Harrison, KL Walton, RI McLachlan, L O'Donnell, ...
Endocrinology 152 (4), 1670-1683, 2011
|Differential effects of IL6 and activin A in the development of cancer-associated cachexia|
JL Chen, KL Walton, H Qian, TD Colgan, A Hagg, MJ Watt, CA Harrison, ...
Cancer research 76 (18), 5372-5382, 2016
|Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice|
CE Winbanks, KT Murphy, BC Bernardo, H Qian, Y Liu, PV Sepulveda, ...
Science translational medicine 8 (348), 348ra98-348ra98, 2016
|The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma|
R Coulson, SH Liew, AA Connelly, NS Yee, S Deb, B Kumar, AC Vargas, ...
Oncotarget 8 (12), 18640, 2017
|Activin signaling regulates Sertoli cell differentiation and function|
PK Nicholls, PG Stanton, JL Chen, JS Olcorn, JT Haverfield, H Qian, ...
Endocrinology 153 (12), 6065-6077, 2012
|The TGF-β signalling network in muscle development, adaptation and disease|
JL Chen, TD Colgan, KL Walton, P Gregorevic, CA Harrison
Growth Factors and Cytokines in Skeletal Muscle Development, Growth …, 2016
|Development of novel activin-targeted therapeutics|
JL Chen, KL Walton, SL Al-Musawi, EK Kelly, H Qian, M La, L Lu, ...
Molecular Therapy 23 (3), 434-444, 2015
|BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9|
LC Patiño, KL Walton, TD Mueller, KE Johnson, W Stocker, D Richani, ...
The Journal of Clinical Endocrinology & Metabolism 102 (3), 1009-1019, 2017
|Inhibin B Is a More Potent Suppressor of Rat Follicle-Stimulating Hormone Release than Inhibin A in Vitro and in Vivo|
Y Makanji, PD Temple-Smith, KL Walton, CA Harrison, DM Robertson
Endocrinology 150 (10), 4784-4793, 2009
|Suppression of inhibin A biological activity by alterations in the binding site for betaglycan|
Y Makanji, KL Walton, MC Wilce, KL Chan, DM Robertson, CA Harrison
Journal of Biological Chemistry 283 (24), 16743-16751, 2008
|Activation of Latent Human GDF9 by a Single Residue Change (Gly391Arg) in the Mature Domain|
CM Simpson, PG Stanton, KL Walton, KL Chan, LJ Ritter, RB Gilchrist, ...
Endocrinology 153 (3), 1301-1310, 2012
|Species differences in the expression and activity of bone morphogenetic protein 15|
SL Al-Musawi, KL Walton, D Heath, CM Simpson, CA Harrison
Endocrinology 154 (2), 888-899, 2013