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Dr Kelly Walton
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Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis
KL Walton, KE Johnson, CA Harrison
Frontiers in pharmacology 8, 461, 2017
4482017
Elevated expression of activins promotes muscle wasting and cachexia
JL Chen, KL Walton, CE Winbanks, KT Murphy, RE Thomson, Y Makanji, ...
The FASEB Journal 28 (4), 1711-1723, 2014
2112014
Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands
CA Harrison, SL Al-Musawi, KL Walton
Growth factors 29 (5), 174-186, 2011
1422011
Structural basis for potency differences between GDF8 and GDF11
RG Walker, M Czepnik, EJ Goebel, JC McCoy, A Vujic, M Cho, J Oh, ...
BMC biology 15, 1-22, 2017
1172017
Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease
JL Chen, KL Walton, A Hagg, TD Colgan, K Johnson, H Qian, ...
Proceedings of the National Academy of Sciences 114 (26), E5266-E5275, 2017
1132017
New insights into the mechanisms of activin action and inhibition
KL Walton, Y Makanji, CA Harrison
Molecular and cellular endocrinology 359 (1-2), 2-12, 2012
1122012
Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-β1 complex
KL Walton, Y Makanji, J Chen, MC Wilce, KL Chan, DM Robertson, ...
Journal of Biological Chemistry 285 (22), 17029-17037, 2010
1052010
A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor β (TGFβ) ligands
KL Walton, Y Makanji, MC Wilce, KL Chan, DM Robertson, CA Harrison
Journal of Biological Chemistry 284 (14), 9311-9320, 2009
1022009
Hormonal regulation of sertoli cell micro-RNAs at spermiation
PK Nicholls, CA Harrison, KL Walton, RI McLachlan, L O'Donnell, ...
Endocrinology 152 (4), 1670-1683, 2011
872011
Differential effects of IL6 and activin A in the development of cancer-associated cachexia
JL Chen, KL Walton, H Qian, TD Colgan, A Hagg, MJ Watt, CA Harrison, ...
Cancer research 76 (18), 5372-5382, 2016
822016
Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice
CE Winbanks, KT Murphy, BC Bernardo, H Qian, Y Liu, PV Sepulveda, ...
Science translational medicine 8 (348), 348ra98-348ra98, 2016
772016
The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma
R Coulson, SH Liew, AA Connelly, NS Yee, S Deb, B Kumar, AC Vargas, ...
Oncotarget 8 (12), 18640, 2017
742017
Activin signaling regulates Sertoli cell differentiation and function
PK Nicholls, PG Stanton, JL Chen, JS Olcorn, JT Haverfield, H Qian, ...
Endocrinology 153 (12), 6065-6077, 2012
742012
The TGF-β signalling network in muscle development, adaptation and disease
JL Chen, TD Colgan, KL Walton, P Gregorevic, CA Harrison
Growth Factors and Cytokines in Skeletal Muscle Development, Growth …, 2016
732016
Development of novel activin-targeted therapeutics
JL Chen, KL Walton, SL Al-Musawi, EK Kelly, H Qian, M La, L Lu, ...
Molecular Therapy 23 (3), 434-444, 2015
652015
BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9
LC Patiņo, KL Walton, TD Mueller, KE Johnson, W Stocker, D Richani, ...
The Journal of Clinical Endocrinology & Metabolism 102 (3), 1009-1019, 2017
602017
Inhibin B Is a More Potent Suppressor of Rat Follicle-Stimulating Hormone Release than Inhibin A in Vitro and in Vivo
Y Makanji, PD Temple-Smith, KL Walton, CA Harrison, DM Robertson
Endocrinology 150 (10), 4784-4793, 2009
592009
Suppression of inhibin A biological activity by alterations in the binding site for betaglycan
Y Makanji, KL Walton, MC Wilce, KL Chan, DM Robertson, CA Harrison
Journal of Biological Chemistry 283 (24), 16743-16751, 2008
572008
Activation of Latent Human GDF9 by a Single Residue Change (Gly391Arg) in the Mature Domain
CM Simpson, PG Stanton, KL Walton, KL Chan, LJ Ritter, RB Gilchrist, ...
Endocrinology 153 (3), 1301-1310, 2012
522012
Species differences in the expression and activity of bone morphogenetic protein 15
SL Al-Musawi, KL Walton, D Heath, CM Simpson, CA Harrison
Endocrinology 154 (2), 888-899, 2013
492013
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Articles 1–20