| EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation W Béguelin, R Popovic, M Teater, Y Jiang, KL Bunting, M Rosen, H Shen, ... Cancer cell 23 (5), 677-692, 2013 | 904 | 2013 |
| Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation R Popovic, E Martinez-Garcia, EG Giannopoulou, Q Zhang, Q Zhang, ... PLoS genetics 10 (9), e1004566, 2014 | 219 | 2014 |
| The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer T Ezponda, R Popovic, MY Shah, E Martinez-Garcia, Y Zheng, DJ Min, ... Oncogene 32 (23), 2882-2890, 2013 | 192 | 2013 |
| Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence S Turcan, V Makarov, J Taranda, Y Wang, AWM Fabius, W Wu, Y Zheng, ... Nature genetics 50 (1), 62-72, 2018 | 166 | 2018 |
| Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3 Y Zheng, SMM Sweet, R Popovic, E Martinez-Garcia, JD Tipton, ... Proceedings of the National Academy of Sciences 109 (34), 13549-13554, 2012 | 139 | 2012 |
| Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies JA Oyer, X Huang, Y Zheng, J Shim, T Ezponda, Z Carpenter, M Allegretta, ... Leukemia 28 (1), 198-201, 2014 | 136 | 2014 |
| UTX/KDM6A loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition T Ezponda, D Dupéré-Richer, CM Will, EC Small, N Varghese, T Patel, ... Cell reports 21 (3), 628-640, 2017 | 133 | 2017 |
| Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites Y Zheng, PM Thomas, NL Kelleher Nature communications 4 (1), 2203, 2013 | 131 | 2013 |
| Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II Y Zheng, S John, JJ Pesavento, JR Schultz-Norton, RL Schiltz, S Baek, ... Journal of Cell Biology 189 (3), 407-415, 2010 | 126 | 2010 |
| The first pilot project of the consortium for top‐down proteomics: a status report X Dang, J Scotcher, S Wu, RK Chu, N Tolić, I Ntai, PM Thomas, RT Fellers, ... Proteomics 14 (10), 1130-1140, 2014 | 114 | 2014 |
| Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry Y Zheng, X Huang, NL Kelleher Current opinion in chemical biology 33, 142-150, 2016 | 73 | 2016 |
| Unabridged analysis of human histone H3 by differential top-down mass spectrometry reveals hypermethylated proteoforms from MMSET/NSD2 overexpression Y Zheng, L Fornelli, PD Compton, S Sharma, J Canterbury, C Mullen, ... Molecular & Cellular Proteomics 15 (3), 776-790, 2016 | 71 | 2016 |
| Separation of variant methylated histone tails by differential ion mobility AA Shvartsburg, Y Zheng, RD Smith, NL Kelleher Analytical chemistry 84 (15), 6317-6320, 2012 | 61 | 2012 |
| Ion mobility separation of variant histone tails extending to the “middle-down” range AA Shvartsburg, Y Zheng, RD Smith, NL Kelleher Analytical chemistry 84 (10), 4271-4276, 2012 | 52 | 2012 |
| Oncogene‐induced cellular senescence elicits an anti‐W arburg effect M Li, KR Durbin, SMM Sweet, JD Tipton, Y Zheng, NL Kelleher Proteomics 13 (17), 2585-2596, 2013 | 49 | 2013 |
| Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation T Hattori, D Lai, IS Dementieva, SP Montaño, K Kurosawa, Y Zheng, ... Proceedings of the National Academy of Sciences 113 (8), 2092-2097, 2016 | 44 | 2016 |
| Proteomics guided discovery of flavopeptins: Anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase Y Chen, RA McClure, Y Zheng, RJ Thomson, NL Kelleher Journal of the American Chemical Society 135 (28), 10449-10456, 2013 | 40 | 2013 |
| Site‐specific human histone H3 methylation stability: fast K4me3 turnover Y Zheng, JD Tipton, PM Thomas, NL Kelleher, SMM Sweet Proteomics 14 (19), 2190-2199, 2014 | 39 | 2014 |
| A synthetic biology approach to probing nucleosome symmetry Y Ichikawa, CF Connelly, A Appleboim, TCR Miller, H Jacobi, NA Abshiru, ... elife 6, e28836, 2017 | 21 | 2017 |
| Loss of the histone demethylase UTX contributes to multiple myeloma and sensitizes cells to EZH2 inhibitors T Ezponda, R Popovic, Y Zheng, B Nabet, C Will, EC Small, ... Blood 124 (21), 611, 2014 | 8 | 2014 |
Steve MM SweetScientist, AstraZeneca, MD, USAVerified email at astrazeneca.com
