Joshua J McElwee
Joshua J McElwee
Genetics Lead, Merck and Co.
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Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease
B Zhang, C Gaiteri, LG Bodea, Z Wang, J McElwee, AA Podtelezhnikov, ...
Cell 153 (3), 707-720, 2013
Activated STING in a vascular and pulmonary syndrome
Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ...
New England Journal of Medicine 371 (6), 507-518, 2014
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
HS Kuehn, W Ouyang, B Lo, EK Deenick, JE Niemela, DT Avery, ...
Science 345 (6204), 1623-1627, 2014
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
C Burnett, S Valentini, F Cabreiro, M Goss, M Somogyvári, MD Piper, ...
nature 477 (7365), 482-485, 2011
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
MWL Teng, EP Bowman, JJ McElwee, MJ Smyth, JL Casanova, ...
Nature medicine 21 (7), 719-729, 2015
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
B Lo, K Zhang, W Lu, L Zheng, Q Zhang, C Kanellopoulou, Y Zhang, Z Liu, ...
Science 349 (6246), 436-440, 2015
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
R Doonan, JJ McElwee, F Matthijssens, GA Walker, K Houthoofd, P Back, ...
Genes & development 22 (23), 3236-3241, 2008
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16
J McElwee, K Bubb, JH Thomas
Aging cell 2 (2), 111-121, 2003
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
JD Milner, TP Vogel, L Forbes, CA Ma, A Stray-Pedersen, JE Niemela, ...
Blood, The Journal of the American Society of Hematology 125 (4), 591-599, 2015
Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
JJ McElwee, E Schuster, E Blanc, JH Thomas, D Gems
Journal of Biological Chemistry 279 (43), 44533-44543, 2004
Evolutionary conservation of regulated longevity assurance mechanisms
JJ McElwee, E Schuster, E Blanc, MD Piper, JH Thomas, DS Patel, ...
Genome biology 8 (7), 1-16, 2007
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
CL Lucas, Y Zhang, A Venida, Y Wang, J Hughes, J McElwee, M Butrick, ...
Journal of Experimental Medicine 211 (13), 2537-2547, 2014
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number
JJ Lyons, X Yu, JD Hughes, QT Le, A Jamil, Y Bai, N Ho, M Zhao, Y Liu, ...
Nature genetics 48 (12), 1564-1569, 2016
Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment
Y Zhang, X Yu, M Ichikawa, JJ Lyons, S Datta, IT Lamborn, H Jing, ES Kim, ...
Journal of Allergy and Clinical Immunology 133 (5), 1400-1409. e5, 2014
Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?
MDW Piper, C Selman, JJ McElwee, L Partridge
Journal of internal medicine 263 (2), 179-191, 2008
Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?
D Gems, JJ McElwee
Mechanisms of ageing and development 126 (3), 381-387, 2005
DamID in C. elegans reveals longevity‐associated targets of DAF‐16/FoxO
E Schuster, JJ McElwee, JMA Tullet, R Doonan, F Matthijssens, ...
Molecular systems biology 6 (1), 399, 2010
Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
JJ McElwee, E Schuster, E Blanc, J Thornton, D Gems
Mechanisms of ageing and development 127 (5), 458-472, 2006
Germline hypomorphic CARD11 mutations in severe atopic disease
CA Ma, JR Stinson, Y Zhang, JK Abbott, MA Weinreich, PJ Hauk, ...
Nature genetics 49 (8), 1192-1201, 2017
Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency
H Abolhassani, ESJ Edwards, A Ikinciogullari, H Jing, S Borte, M Buggert, ...
Journal of Experimental Medicine 214 (1), 91-106, 2017
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