| Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome H Hahn, C Wicking, PG Zaphiropoulos, MR Gailani, S Shanley, ... Cell 85 (6), 841-851, 1996 | 2444 | 1996 |
| Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes JK White, AK Gerdin, NA Karp, E Ryder, M Buljan, JN Bussell, J Salisbury, ... Cell 154 (2), 452-464, 2013 | 519 | 2013 |
| Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. C Wicking, S Shanley, I Smyth, S Gillies, K Negus, S Graham, G Suthers, ... American journal of human genetics 60 (1), 21, 1997 | 337 | 1997 |
| Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32 I Smyth, MA Narang, T Evans, C Heimann, Y Nakamura, ... Human molecular genetics 8 (2), 291-297, 1999 | 279 | 1999 |
| Global quantification of tissue dynamics in the developing mouse kidney KM Short, AN Combes, J Lefevre, AL Ju, KM Georgas, T Lamberton, ... Developmental cell 29 (2), 188-202, 2014 | 260 | 2014 |
| The hedgehog signalling pathway in tumorigenesis and development. C Wicking, I Smyth, A Bale Oncogene 18 (55), 7844, 1999 | 248 | 1999 |
| Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs S Jadeja, I Smyth, JE Pitera, MS Taylor, M Van Haelst, E Bentley, ... Nature genetics 37 (5), 520-525, 2005 | 180 | 2005 |
| Human sebaceous tumors harbor inactivating mutations in LEF1 H Takeda, S Lyle, AJF Lazar, CC Zouboulis, I Smyth, FM Watt Nature medicine 12 (4), 395-397, 2006 | 171 | 2006 |
| The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis I Smyth, X Du, MS Taylor, MJ Justice, B Beutler, IJ Jackson Proceedings of the National Academy of Sciences 101 (37), 13560-13565, 2004 | 131 | 2004 |
| Patched 1 conditional null allele in mice T Ellis, I Smyth, E Riley, S Graham, K Elliot, M Narang, GF Kay, C Wicking, ... Genesis 36 (3), 158-161, 2003 | 113 | 2003 |
| INPP5E regulates phosphoinositide-dependent cilia transition zone function JM Dyson, SE Conduit, SJ Feeney, S Hakim, T DiTommaso, AJ Fulcher, ... Journal of Cell Biology 216 (1), 247-263, 2017 | 105 | 2017 |
| Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice M François, K Short, GA Secker, A Combes, Q Schwarz, TL Davidson, ... Developmental biology 364 (2), 89-98, 2012 | 103 | 2012 |
| Heterozygous Mutations of FREM1 Are Associated with an Increased Risk of Isolated Metopic Craniosynostosis in Humans and Mice LELM Vissers, TC Cox, AM Maga, KM Short, F Wiradjaja, IM Janssen, ... PLoS genetics 7 (9), e1002278, 2011 | 101 | 2011 |
| Palmitoylation regulates epidermal homeostasis and hair follicle differentiation P Mill, AWS Lee, Y Fukata, R Tsutsumi, M Fukata, M Keighren, RM Porter, ... PLoS genetics 5 (11), e1000748, 2009 | 97 | 2009 |
| Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors N Gorinski, M Bijata, S Prasad, A Wirth, D Abdel Galil, A Zeug, ... Nature Communications 10 (1), 3924, 2019 | 93 | 2019 |
| INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability OV Plotnikova, S Seo, DL Cottle, S Conduit, S Hakim, JM Dyson, ... Journal of cell science 128 (2), 364-372, 2015 | 92 | 2015 |
| The genetics of Fraser syndrome and the blebs mouse mutants I Smyth, P Scambler Human Molecular Genetics 14 (suppl_2), R269-R274, 2005 | 91 | 2005 |
| Spatial mapping and quantification of developmental branching morphogenesis K Short, M Hodson, I Smyth Development 140 (2), 471-478, 2013 | 89 | 2013 |
| The contribution of branching morphogenesis to kidney development and disease KM Short, IM Smyth Nature Reviews Nephrology 12 (12), 754-767, 2016 | 86 | 2016 |
| A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis I Smyth, DF Hacking, AA Hilton, N Mukhamedova, PJ Meikle, S Ellis, ... PLoS genetics 4 (9), e1000192, 2008 | 83 | 2008 |
