Sam El-Ajouz
Sam El-Ajouz
Immunocore
Verified email at immunocore.com
TitleCited byYear
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
M Grieben, ACW Pike, CA Shintre, E Venturi, S El-Ajouz, A Tessitore, ...
Nature structural & molecular biology 24 (2), 114, 2017
842017
Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors
JA Roberts, HR Digby, M Kara, S El Ajouz, MJ Sutcliffe, RJ Evans
Journal of Biological Chemistry 283 (29), 20126-20136, 2008
592008
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
JA Roberts, RC Allsopp, S El Ajouz, C Vial, R Schmid, MT Young, ...
Proceedings of the National Academy of Sciences 109 (12), 4663-4667, 2012
552012
Cysteine Scanning Mutagenesis (Residues Glu52–Gly96) of the Human P2X1 Receptor for ATP MAPPING AGONIST BINDING AND CHANNEL GATING
RC Allsopp, S El Ajouz, R Schmid, RJ Evans
Journal of Biological Chemistry 286 (33), 29207-29217, 2011
452011
Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine‐rich loop
S El‐Ajouz, D Ray, RC Allsopp, RJ Evans
British journal of pharmacology 165 (2), 390-400, 2012
372012
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC‐A
S El‐Ajouz, E Venturi, K Witschas, M Beech, AD Wilson, C Lindsay, ...
The Journal of physiology 595 (14), 4769-4784, 2017
72017
Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents
F O'Brien, D Eberhardt, K Witschas, S El‐Ajouz, T Iida, M Nishi, ...
The Journal of physiology 597 (10), 2691-2705, 2019
22019
Enhanced activity of multiple TRIC-B channels; an ER/SR mechanism to boost counterion currents
F O’Brien, D Eberhardt, K Witschas, S El-Ajouz, T Iida, M Nishi, ...
J Physiol (Lond), 2019
12019
Differential Effects of Temperature and Lipids on the Gating of RyR and SR K+ Channels
S El-Ajouz, E Venturi, R Sitsapesan
Biophysical Journal 110 (3), 266a, 2016
12016
Dampened Activity of Single Ryanodine Receptor Channels in Mice Devoid of TRIC-A
K Witschas, F O'Brien, E Venturi, S El-Ajouz, M Beech, D Eberhardt, T Iida, ...
Biophysical Journal 110 (3), 266a, 2016
12016
Cooperative Gating Among Ion-Channel Species in Junctional Sarcoplasmic Reticulum
E Venturi, F O'Brien, D Eberhardt, K Witschas, S El-Ajouz, T Iida, ...
Biophysical Journal 116 (3), 521a, 2019
2019
Single ryanodine receptor channels from the skeletal muscle of TRIC-A knockout mice show reduced activation by Mg2+ ATP
K Witschas, S El-Ajouz, E Venturi, M Beech, F O'Brien, D Eberhardt, T Iida, ...
Physiology 2016 Joint Meeting of the American Physiological Society and The …, 2016
2016
Cardiac and skeletal sarcoplasmic reticulum K+ channels from TRIC-A knockout mice show distinct gating characteristics to those derived from wild type mice
D Eberhardt, F O'Brien, E Venturi, K Witschas, S El-Ajouz, T Iida, M Nishi, ...
Physiology 2016 Joint Meeting of the American Physiological Society and The …, 2016
2016
Understanding the Molecular Gates of KirBac3. 1
S El-Ajouz, AP Hill, JM Gulbis, JI Vandenberg
Biophysical Journal 104 (2), 128a, 2013
2013
Molecular basis of antagonist action at the P2X1 receptor
S El-Ajouz
University of Leicester, 2011
2011
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Articles 1–15