| Structure-guided design of a selective BCL-XL inhibitor G Lessene, PE Czabotar, BE Sleebs, K Zobel, KN Lowes, JM Adams, ... Nature chemical biology 9 (6), 390-397, 2013 | 440 | 2013 |
| Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ... ACS medicinal chemistry letters 5 (10), 1088-1093, 2014 | 321 | 2014 |
| Mitoxantrone, More than Just Another Topoisomerase II Poison BJ Evison, BE Sleebs, KG Watson, DR Phillips, SM Cutts Medicinal Research Reviews 36 (2), 248-299, 2016 | 194 | 2016 |
| Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis W Wong, XC Bai, BE Sleebs, T Triglia, A Brown, JK Thompson, ... Nature microbiology 2 (6), 1-9, 2017 | 182 | 2017 |
| Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome JA Boddey, TG Carvalho, AN Hodder, TJ Sargeant, BE Sleebs, ... Traffic 14 (5), 532-550, 2013 | 170 | 2013 |
| Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites BE Sleebs, S Lopaticki, DS Marapana, MT O'Neill, P Rajasekaran, ... PLoS biology 12 (7), e1001897, 2014 | 153 | 2014 |
| Screening the medicines for malaria venture pathogen box across multiple pathogens reclassifies starting points for open-source drug discovery S Duffy, ML Sykes, AJ Jones, TB Shelper, M Simpson, R Lang, ... Antimicrobial agents and chemotherapy 61 (9), 10.1128/aac. 00379-17, 2017 | 137 | 2017 |
| Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle P Favuzza, M de Lera Ruiz, JK Thompson, T Triglia, A Ngo, RWJ Steel, ... Cell host & microbe 27 (4), 642-658. e12, 2020 | 122 | 2020 |
| An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell MJ Coffey, BE Sleebs, AD Uboldi, A Garnham, M Franco, ND Marino, ... Elife 4, e10809, 2015 | 119 | 2015 |
| Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands EF Lee, PE Czabotar, H Yang, BE Sleebs, G Lessene, PM Colman, ... Journal of Biological Chemistry 284 (44), 30508-30517, 2009 | 116 | 2009 |
| Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes AN Hodder, BE Sleebs, PE Czabotar, M Gazdik, Y Xu, M T O'Neill, ... Nature Structural & Molecular Biology 22, 590-596, 2015 | 109 | 2015 |
| Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-XL BE Sleebs, WJA Kersten, S Kulasegaram, G Nikolakopoulos, E Hatzis, ... Journal of Medicinal Chemistry 56 (13), 5514-5540, 2013 | 87 | 2013 |
| Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity BE Sleebs, PE Czabotar, WJ Fairbrother, WD Fairlie, JA Flygare, ... Journal of medicinal chemistry 54 (6), 1914-1926, 2011 | 85 | 2011 |
| An appraisal of natural products active against parasitic nematodes of animals JF Garcia-Bustos, BE Sleebs, RB Gasser Parasites & Vectors 12, 1-22, 2019 | 81 | 2019 |
| Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum DW Wilson, CD Goodman, BE Sleebs, GE Weiss, NWM de Jong, ... BMC biology 13 (52), 1, 2015 | 80 | 2015 |
| The development process for discovery and clinical advancement of modern antimalarials TD Ashton, SM Devine, JJ Mohrle, B Laleu, JN Burrows, SA Charman, ... Journal of Medicinal Chemistry 62 (23), 10526-10562, 2019 | 76 | 2019 |
| The facile production of N-methyl amino acids via oxazolidinones L Aurelio, RTC Brownlee, AB Hughes, BE Sleebs Australian Journal of Chemistry 53 (5), 425-433, 2000 | 71 | 2000 |
| Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design JM 13. Brouwer, P Lan, AD Cowan, JP Bernardini, RW Birkinshaw, ... Cell Reports 68, 659-672, 2017 | 62 | 2017 |
| Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax BE Sleebs, M Gazdik, MT O’Neill, P Rajasekaran, S Lopaticki, K Lackovic, ... Journal of medicinal chemistry 57 (18), 7644-7662, 2014 | 60 | 2014 |
| Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity PR Gilson, C Tan, KE Jarman, KN Lowes, JM Curtis, W Nguyen, ... Journal of Medicinal Chemistry, 2017 | 59 | 2017 |
Jonathan BaellExecutive Director Early Leads Chemistry, Lyterian TherapeuticsVerified email at lyterian.com
