Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT R Edayathumangalam, R Wu, R Garcia, Y Wang, W Wang, CA Kreinbring, ... Proceedings of the National Academy of Sciences 110 (44), 17820-17825, 2013 | 74 | 2013 |
The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile S Martinez, R Wu, R Sanishvili, D Liu, R Holz Journal of the American Chemical Society 136 (4), 1186-1189, 2014 | 63 | 2014 |
Rational Design of a Transition State Analogue with Picomolar Affinity for Pseudomonas aeruginosa PvdQ, a Siderophore Biosynthetic Enzyme KD Clevenger, R Wu, JAV Er, D Liu, W Fast ACS chemical biology 8 (10), 2192-2200, 2013 | 46 | 2013 |
Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115) H Lee, EH Doud, R Wu, R Sanishvili, JI Juncosa, D Liu, NL Kelleher, ... Journal of the American Chemical Society 137 (7), 2628-2640, 2015 | 34 | 2015 |
PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation R Wu, R Sanishvili, BR Belitsky, JI Juncosa, HV Le, HJS Lehrer, M Farley, ... Proceedings of the National Academy of Sciences 114 (15), 3891-3896, 2017 | 33 | 2017 |
SIMBAD: a sequence-independent molecular-replacement pipeline AJ Simpkin, F Simkovic, JMH Thomas, M Savko, A Lebedev, V Uski, ... Acta Crystallographica Section D: Structural Biology 74 (7), 595-605, 2018 | 32 | 2018 |
Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators HV Le, DD Hawker, R Wu, E Doud, J Widom, R Sanishvili, D Liu, ... Journal of the American Chemical Society 137 (13), 4525-4533, 2015 | 30 | 2015 |
The crystal structure of Nitrosomonas europaea sucrose synthase reveals critical conformational changes and insights into sucrose metabolism in prokaryotes R Wu, MD Asención Diez, CM Figueroa, M Machtey, AA Iglesias, ... Journal of Bacteriology 197 (17), 2734-2746, 2015 | 29 | 2015 |
n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ KD Clevenger, R Wu, D Liu, W Fast Biochemistry 53 (42), 6679-6686, 2014 | 17 | 2014 |
Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid H Lee, HV Le, R Wu, E Doud, R Sanishvili, JF Kellie, PD Compton, ... ACS chemical biology 10 (9), 2087-2098, 2015 | 16 | 2015 |
Analyzing the catalytic role of active site residues in the Fe-type nitrile hydratase from Comamonas testosteroni Ni1 S Martinez, R Wu, K Krzywda, V Opalka, H Chan, D Liu, RC Holz JBIC Journal of Biological Inorganic Chemistry 20, 885-894, 2015 | 10 | 2015 |
Molecular mechanism and ligand design of a PLP/GABA-dependent bacterial transcription regulator GabR E Cybulla, R Wu, C Reidl, D Gawron, D Becker, D Liu ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 249, 2015 | | 2015 |
Structure and Molecular Mechanism of a PLP/GABA Dependent Transcription Regulator GabR R Wu | | 2015 |