| Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1 H Johnen, S Lin, T Kuffner, DA Brown, VWW Tsai, AR Bauskin, L Wu, ... Nature medicine 13 (11), 1333-1340, 2007 | 631 | 2007 |
| The MIC-1/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases VWW Tsai, Y Husaini, A Sainsbury, DA Brown, SN Breit Cell metabolism 28 (3), 353-368, 2018 | 303 | 2018 |
| TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator VWW Tsai, L Macia, H Johnen, T Kuffner, R Manadhar, SB Jørgensen, ... PloS one 8 (2), e55174, 2013 | 201 | 2013 |
| TGF-b Superfamily Cytokine MIC-1 VWW Tsai, L Macia, H Johnen, T Kuffner, R Manadhar GDF15 Is a Physiological Appetite and Body, 2013 | 201* | 2013 |
| Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets L Macia, VWW Tsai, AD Nguyen, H Johnen, T Kuffner, YC Shi, S Lin, ... PloS one 7 (4), e34868, 2012 | 198 | 2012 |
| Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease SN Breit, JJ Carrero, VWW Tsai, N Yagoutifam, W Luo, T Kuffner, ... Nephrology dialysis transplantation 27 (1), 70-75, 2012 | 130 | 2012 |
| Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification L Jiang, K Salao, H Li, JM Rybicka, RM Yates, XW Luo, XX Shi, T Kuffner, ... Journal of cell science 125 (22), 5479-5488, 2012 | 113 | 2012 |
| Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15 VWW Tsai, S Lin, DA Brown, A Salis, SN Breit International journal of obesity 40 (2), 193-197, 2016 | 110 | 2016 |
| The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract VWW Tsai, R Manandhar, SB Jørgensen, KKM Lee-Ng, HP Zhang, ... PloS one 9 (6), e100370, 2014 | 107 | 2014 |
| The GDF15-GFRAL pathway in health and metabolic disease: Friend or foe? SN Breit, DA Brown, VWW Tsai Annual Review of Physiology 83, 127-151, 2021 | 100 | 2021 |
| Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice Y Husaini, MR Qiu, GP Lockwood, XW Luo, P Shang, T Kuffner, ... PloS one 7 (8), e43833, 2012 | 81 | 2012 |
| Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity VW Tsai, HP Zhang, R Manandhar, KKM Lee-Ng, H Lebhar, CP Marquis, ... International journal of obesity 42 (3), 561-571, 2018 | 80 | 2018 |
| Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI VWW Tsai, L Macia, C Feinle-Bisset, R Manandhar, A Astrup, A Raben, ... PLoS One 10 (7), e0133362, 2015 | 74 | 2015 |
| Targeting obesity and cachexia: identification of the GFRAL receptor–MIC-1/GDF15 pathway SN Breit, VWW Tsai, DA Brown Trends in Molecular Medicine 23 (12), 1065-1067, 2017 | 71 | 2017 |
| Tumor necrosis factor-α–elicited stimulation of γ-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin LH Kuo, MK Hu, WM Hsu, YT Tung, BJ Wang, WW Tsai, CT Yen, YF Liao Molecular Biology of the Cell 19 (10), 4201-4212, 2008 | 64 | 2008 |
| GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS VWW Tsai, HP Zhang, R Manandhar, P Schofield, D Christ, KKM Lee-Ng, ... International Journal of Obesity, 1-11, 2019 | 56 | 2019 |
| The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer’s disease VWW Tsai, HL Scott, RJ Lewis, PR Dodd Neurotoxicity research 7 (1-2), 125-141, 2005 | 52 | 2005 |
| CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis K Salao, L Jiang, H Li, VWW Tsai, Y Husaini, PMG Curmi, LJ Brown, ... Biology open 5 (5), 620-630, 2016 | 35 | 2016 |
| Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice Y Husaini, GP Lockwood, TV Nguyen, VWW Tsai, MG Mohammad, ... PLoS One 10 (2), e0115189, 2015 | 31 | 2015 |
| Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity Y Husaini, VWW Tsai, R Manandhar, HP Zhang, KKM Lee-Ng, H Lebhar, ... PloS one 15 (6), e0233846, 2020 | 18 | 2020 |
