|Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis|
TRM Lannagan, YK Lee, T Wang, J Roper, ML Bettington, L Fennell, ...
Gut 68 (4), 684-692, 2019
|Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia|
CE Bond, C Liu, F Kawamata, DM McKeone, W Fernando, S Jamieson, ...
Epigenetics 13 (1), 40-48, 2018
|The role of APC in WNT pathway activation in serrated neoplasia|
J Borowsky, T Dumenil, M Bettington, SA Pearson, C Bond, L Fennell, ...
Modern Pathology 31 (3), 495-504, 2018
|Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals 5 distinct subtypes of colorectal adenocarcinomas|
L Fennell, T Dumenil, L Wockner, G Hartel, K Nones, C Bond, J Borowsky, ...
Cellular and molecular gastroenterology and hepatology 8 (2), 269-290, 2019
|Copy number profiles of paired primary and metastatic colorectal cancers|
F Kawamata, AM Patch, K Nones, C Bond, D McKeone, SA Pearson, ...
Oncotarget 9 (3), 3394, 2018
|MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation|
LJ Fennell, S Jamieson, D McKeone, T Corish, M Rohdmann, T Furner, ...
BMC cancer 18 (1), 35, 2018
|RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers|
LJ Fennell, M Clendenning, DM McKeone, SH Jamieson, S Balachandran, ...
Familial cancer 17 (1), 63-69, 2018
|Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer|
AM Kane, LJ Fennell, C Liu, J Borowsky, DM McKeone, CE Bond, ...
Neoplasia 22 (2), 120-128, 2020
|APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers|
LJ Fennell, A Kane, C Liu, D McKeone, W Fernando, C Su, C Bond, ...
Cancers 12 (5), 1171, 2020
|DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas|
C Liu, LJ Fennell, ML Bettington, NI Walker, J Dwine, BA Leggett, ...
Clinical epigenetics 11 (1), 90, 2019
|IDDF2020-ABS-0158 BRAF mutation induces rapid neoplastic transformation in the aged and extensively hypermethylated intestinal epithelium|
L Fennell, A Kane, C Liu, D McKeone, G Hartel, C Bond, M Bettington, ...
Gut 69 (Suppl 2), A21-A21, 2020
|Aspirin reduces the incidence of metastasis in a preclinical study of Braf mutant colorectal cancer|
A Kane, C Liu, L Fennell, D McKeone, J Borowsky, B Leggett, V Whitehall
Cancer Research 80 (16 Supplement), 1103-1103, 2020
|Intestinal epigenetic age and risk of sessile serrated adenoma progression to cancer|
L Fennell, A Kane, D Mckeone, C Bond, B Leggett, V Whitehall
Journal of Gastroenterology and Hepatology 34, 38-39, 2019
|BRAF and KRAS mutation define distinct subtypes of the CpG island methylator phenotype in colorectal cancers|
VL Whitehall, L Fennell, T Dumenil, G Hartel, K Nones, C Bond, ...
Cancer Research 79 (13 Supplement), 479-479, 2019
|Genome-wide DNA methylation, transcription, and mutation analysis of the colorectal cancer epigenome|
L Fennell, T Dumenil, AM Patch, S Kazakoff, K Nones, G Hartel, C Bond, ...
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 33, 17-17, 2018
|Oncogenic BRAF mutation induces widespread DNA hypermethylation in a murine model for human serrated colorectal neoplasia|
V Whitehall, C Bond, C Liu, F Kawamata, D McKeone, S Jamieson, ...
Cancer Research 77 (13 Supplement), 5375-5375, 2017
|Abstract PR04: Wnt and MAPK pathway activation in conventional and serrated colorectal neoplasia|
V Whitehall, J Borowsky, C Bond, M Bettington, SA Pearson, M Kalimutho, ...
Cancer Research 77 (3 Supplement), PR04-PR04, 2017
|Copy number profiles of matched primary and metastatic colorectal cancer to investigate clonal tumor changes|
F Kawamata, AM Patch, C Bond, K Nones, D McKeone, SA Pearson, J Liu, ...
Journal of Gastroenterology and Hepatology 32, 60-60, 2017
|MLH1–93 single nucleotide polymorphism predisposes dysplastic sessile serrated adenomas to the development of promoter hypermethylation|
L Fennell, S Jamieson, M Rohdmann, T Furner, D Mckeone, F Kawamata, ...
Journal of Gastroenterology and Hepatology 32, 58-58, 2017