New air-stable catalysts for general and efficient Suzuki− Miyaura cross-coupling reactions of heteroaryl chlorides AS Guram, AO King, JG Allen, X Wang, LB Schenkel, J Chan, EE Bunel, ... Organic letters 8 (9), 1787-1789, 2006 | 203 | 2006 |
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines M Payton, TL Bush, G Chung, B Ziegler, P Eden, P McElroy, S Ross, ... Cancer research 70 (23), 9846-9854, 2010 | 141 | 2010 |
Novel sulfinyl imine ligands for asymmetric catalysis LB Schenkel, JA Ellman Organic Letters 5 (4), 545-548, 2003 | 105 | 2003 |
Synthesis and Resolution of a Novel Chiral Diamine Ligand and Application to Asymmetric Lithiation− Substitution X Li, LB Schenkel, MC Kozlowski Organic Letters 2 (7), 875-878, 2000 | 89 | 2000 |
Self-Condensation of N-tert-Butanesulfinyl Aldimines: Application to the Rapid Asymmetric Synthesis of Biologically Important Amine-Containing Compounds LB Schenkel, JA Ellman Organic Letters 6 (20), 3621-3624, 2004 | 88 | 2004 |
Application of P,N-Sulfinyl Imine Ligands to Iridium-Catalyzed Asymmetric Hydrogenation of Olefins LB Schenkel, JA Ellman The Journal of Organic Chemistry 69 (6), 1800-1802, 2004 | 83 | 2004 |
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that … RF Graceffa, AA Boezio, J Able, S Altmann, LM Berry, C Boezio, JR Butler, ... Journal of medicinal chemistry 60 (14), 5990-6017, 2017 | 64 | 2017 |
Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity LB Schenkel, PR Olivieri, AA Boezio, HL Deak, R Emkey, RF Graceffa, ... Journal of medicinal chemistry 59 (6), 2794-2809, 2016 | 59 | 2016 |
PI3 kinase modulators and methods of use S Booker, N D'angelo, DC D'amico, TS Kim, L Liu, K Meagher, ... US Patent App. 12/221,416, 2009 | 54 | 2009 |
Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors LB Schenkel, X Huang, A Cheng, HL Deak, E Doherty, R Emkey, Y Gu, ... Journal of medicinal chemistry 54 (24), 8440-8450, 2011 | 53 | 2011 |
Aurora kinase modulators and method of use VJ Cee, HN Nguyen, K Romero US Patent 7,560,551, 2009 | 50 | 2009 |
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants LB Schenkel, JR Molina, KK Swinger, R Abo, DJ Blackwell, AZ Lu, ... Cell chemical biology 28 (8), 1158-1168. e13, 2021 | 43 | 2021 |
Discovery of N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally … S Geuns-Meyer, VJ Cee, HL Deak, B Du, BL Hodous, HN Nguyen, ... Journal of Medicinal Chemistry 58 (13), 5189-5207, 2015 | 43 | 2015 |
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine Aurora kinase inhibitor VJ Cee, LB Schenkel, BL Hodous, HL Deak, HN Nguyen, PR Olivieri, ... Journal of medicinal chemistry 53 (17), 6368-6377, 2010 | 43 | 2010 |
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors EF DiMauro, S Altmann, LM Berry, H Bregman, N Chakka, M Chu-Moyer, ... Journal of medicinal chemistry 59 (17), 7818-7839, 2016 | 40 | 2016 |
Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory-and neuropathic-induced mechanical hypersensitivity in rats SG Lehto, AD Weyer, BD Youngblood, M Zhang, R Yin, W Wang, ... Molecular pain 12, 1744806916677761, 2016 | 38 | 2016 |
Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones HN Nguyen, VJ Cee, HL Deak, B Du, KP Faber, H Gunaydin, BL Hodous, ... The Journal of organic chemistry 77 (8), 3887-3906, 2012 | 32 | 2012 |
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR EA Peterson, PS Andrews, X Be, AA Boezio, TL Bush, AC Cheng, ... Bioorganic & medicinal chemistry letters 21 (7), 2064-2070, 2011 | 31 | 2011 |
Development of novel azabenzofuran TRPA1 antagonists as in vivo tools KW Copeland, AA Boezio, E Cheung, J Lee, P Olivieri, LB Schenkel, ... Bioorganic & Medicinal Chemistry Letters 24 (15), 3464-3468, 2014 | 26 | 2014 |
Benzothiazole PI3 kinase modulators for cancer treatment S Booker, N D'angelo, DC D'amico, TS Kim, L Liu, K Meagher, ... US Patent 7,928,140, 2011 | 23 | 2011 |