Tumor immune evasion arises through loss of TNF sensitivity CJ Kearney, SJ Vervoort, SJ Hogg, KM Ramsbottom, AJ Freeman, ... Science immunology 3 (23), eaar3451, 2018 | 293 | 2018 |
Fas/CD95-induced chemokines can serve as “find-me” signals for apoptotic cells SP Cullen, CM Henry, CJ Kearney, SE Logue, M Feoktistova, GA Tynan, ... Molecular cell 49 (6), 1034-1048, 2013 | 237 | 2013 |
Diverse activators of the NLRP3 inflammasome promote IL-1β secretion by triggering necrosis SP Cullen, CJ Kearney, DM Clancy, SJ Martin Cell reports 11 (10), 1535-1548, 2015 | 235 | 2015 |
An inflammatory perspective on necroptosis CJ Kearney, SJ Martin Molecular cell 65 (6), 965-973, 2017 | 210 | 2017 |
Inflammatory outcomes of apoptosis, necrosis and necroptosis P Davidovich, CJ Kearney, SJ Martin Biological chemistry 395 (10), 1163-1171, 2014 | 207 | 2014 |
Necroptosis suppresses inflammation via termination of TNF-or LPS-induced cytokine and chemokine production CJ Kearney, SP Cullen, GA Tynan, CM Henry, D Clancy, EC Lavelle, ... Cell Death & Differentiation 22 (8), 1313-1327, 2015 | 152 | 2015 |
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer SJ Vervoort, SA Welsh, JR Devlin, E Barbieri, DA Knight, S Offley, ... Cell 184 (12), 3143-3162. e32, 2021 | 115 | 2021 |
RIPK1 can function as an inhibitor rather than an initiator of RIPK3‐dependent necroptosis CJ Kearney, SP Cullen, D Clancy, SJ Martin The FEBS journal 281 (21), 4921-4934, 2014 | 89 | 2014 |
Natural killer cells suppress T cell-associated tumor immune evasion AJ Freeman, SJ Vervoort, KM Ramsbottom, MJ Kelly, J Michie, L Pijpers, ... Cell reports 28 (11), 2784-2794. e5, 2019 | 88 | 2019 |
PTPN 2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours F Wiede, KH Lu, X Du, S Liang, K Hochheiser, GT Dodd, PK Goh, ... The EMBO journal 39 (2), e103637, 2020 | 87 | 2020 |
PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF CJ Kearney, N Lalaoui, AJ Freeman, KM Ramsbottom, J Silke, J Oliaro Cell Death & Differentiation 24 (10), 1705-1716, 2017 | 76 | 2017 |
Antagonism of IAPs enhances CAR T-cell efficacy J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, ... Cancer immunology research 7 (2), 183-192, 2019 | 73 | 2019 |
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition SJ Hogg, O Motorna, LA Cluse, TM Johanson, HD Coughlan, R Raviram, ... Molecular cell 81 (10), 2183-2200. e13, 2021 | 72 | 2021 |
CDK4/6 inhibition promotes antitumor immunity through the induction of T-cell memory EJ Lelliott, IY Kong, M Zethoven, KM Ramsbottom, LG Martelotto, ... Cancer discovery 11 (10), 2582-2601, 2021 | 69 | 2021 |
DOCK8 regulates signal transduction events to control immunity CJ Kearney, KL Randall, J Oliaro Cellular & molecular immunology 14 (5), 406-411, 2017 | 69 | 2017 |
Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production CJ Kearney, C Sheridan, SP Cullen, GA Tynan, SE Logue, IS Afonina, ... Journal of Biological Chemistry 288 (7), 4878-4890, 2013 | 57 | 2013 |
Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing CJ Kearney, KM Ramsbottom, I Voskoboinik, PK Darcy, J Oliaro Oncoimmunology 5 (8), e1196308, 2016 | 54 | 2016 |
MAIT cells regulate NK cell-mediated tumor immunity EV Petley, HF Koay, MA Henderson, K Sek, KL Todd, SP Keam, J Lai, ... Nature communications 12 (1), 4746, 2021 | 51 | 2021 |
SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells CJ Kearney, SJ Vervoort, KM Ramsbottom, I Todorovski, EJ Lelliott, ... Science advances 7 (8), eabe3610, 2021 | 51 | 2021 |
The immuno-modulatory effects of inhibitor of apoptosis protein antagonists in cancer immunotherapy J Michie, CJ Kearney, ED Hawkins, J Silke, J Oliaro Cells 9 (1), 207, 2020 | 48 | 2020 |