| Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients CK Wang, SE Northfield, B Colless, S Chaousis, I Hamernig, RJ Lohman, ... Proceedings of the National Academy of Sciences 111 (49), 17504-17509, 2014 | 155 | 2014 |
| Improving on nature: making a cyclic heptapeptide orally bioavailable DS Nielsen, HN Hoang, RJ Lohman, TA Hill, AJ Lucke, DJ Craik, ... Angewandte Chemie International Edition 53 (45), 12059-12063, 2014 | 150 | 2014 |
| Diet‐induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism J Lim, A Iyer, L Liu, JY Suen, RJ Lohman, V Seow, MK Yau, L Brown, ... The FASEB Journal 27 (12), 4757-4767, 2013 | 128 | 2013 |
| Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) JY Suen, GD Barry, RJ Lohman, MA Halili, AJ Cotterell, GT Le, DP Fairlie British journal of pharmacology 165 (5), 1413-1423, 2012 | 125 | 2012 |
| An antagonist of human protease activated receptor‐2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen‐induced arthritis in rats RJ Lohman, AJ Cotterell, GD Barry, L Liu, JY Suen, DA Vesey, DP Fairlie The FASEB Journal 26 (7), 2877-2887, 2012 | 123 | 2012 |
| Antagonism of protease-activated receptor 2 protects against experimental colitis RJ Lohman, AJ Cotterell, J Suen, L Liu, AT Do, DA Vesey, DP Fairlie Journal of Pharmacology and Experimental Therapeutics 340 (2), 256-265, 2012 | 111 | 2012 |
| Pathway‐selective antagonism of proteinase activated receptor 2 JY Suen, A Cotterell, RJ Lohman, J Lim, A Han, MK Yau, L Liu, ... British journal of pharmacology 171 (17), 4112-4124, 2014 | 75 | 2014 |
| Flexibility versus rigidity for orally bioavailable cyclic hexapeptides DS Nielsen, RJ Lohman, HN Hoang, TA Hill, A Jones, AJ Lucke, ... ChemBioChem 16 (16), 2289-2293, 2015 | 70 | 2015 |
| Total synthesis, structure, and oral absorption of a thiazole cyclic peptide, sanguinamide A DS Nielsen, HN Hoang, RJ Lohman, F Diness, DP Fairlie Organic letters 14 (22), 5720-5723, 2012 | 68 | 2012 |
| Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed TA Hill, RJ Lohman, HN Hoang, DS Nielsen, CCG Scully, WM Kok, L Liu, ... ACS medicinal chemistry letters 5 (10), 1148-1151, 2014 | 65 | 2014 |
| Validation of a method for localised microinjection of drugs into thalamic subregions in rats for epilepsy pharmacological studies RJ Lohman, L Liu, M Morris, TJ O’Brien Journal of neuroscience methods 146 (2), 191-197, 2005 | 56 | 2005 |
| Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis RJ Lohman, A Iyer, TJ Fairlie, A Cotterell, P Gupta, RC Reid, DA Vesey, ... Journal of Pharmacology and Experimental Therapeutics 356 (2), 387-396, 2016 | 48 | 2016 |
| PAR2-induced inflammatory responses in human kidney tubular epithelial cells DA Vesey, JY Suen, V Seow, RJ Lohman, L Liu, GC Gobe, DW Johnson, ... American Journal of Physiology-Renal Physiology 304 (6), F737-F750, 2013 | 47 | 2013 |
| Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice RS Harrison, G Ruiz-Gomez, TA Hill, SY Chow, NE Shepherd, ... Journal of medicinal chemistry 53 (23), 8400-8408, 2010 | 46 | 2010 |
| Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists V Seow, J Lim, AJ Cotterell, MK Yau, W Xu, RJ Lohman, WM Kok, ... Scientific reports 6 (1), 24575, 2016 | 45 | 2016 |
| Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy H Starobova, A Mueller, R Allavena, RJ Lohman, MJ Sweet, I Vetter Frontiers in Neuroscience 13, 653, 2019 | 39 | 2019 |
| Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a RJ Lohman, JK Hamidon, RC Reid, JA Rowley, MK Yau, MA Halili, ... Nature communications 8 (1), 351, 2017 | 36 | 2017 |
| Action potential afterdepolarization mediated by a Ca2+-activated cation conductance in myenteric AH neurons F Vogalis, JR Harvey, RJ Lohman, JB Furness Neuroscience 115 (2), 375-393, 2002 | 36 | 2002 |
| Protease-activated receptor-2 regulates trypsin expression in the brain and protects against seizures and epileptogenesis RJ Lohman, TJ O'Brien, TM Cocks Neurobiology of Disease 30 (1), 84-93, 2008 | 33 | 2008 |
| An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice A Do, RC Reid, RJ Lohman, MJ Sweet, DP Fairlie, A Iyer Journal of Pharmacology and Experimental Therapeutics 360 (1), 140-151, 2017 | 32 | 2017 |
