A shear gradient–dependent platelet aggregation mechanism drives thrombus formation WS Nesbitt, E Westein, FJ Tovar-Lopez, E Tolouei, A Mitchell, J Fu, ... Nature medicine 15 (6), 665-673, 2009 | 939 | 2009 |
Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner E Westein, AD van der Meer, MJE Kuijpers, JP Frimat, A van den Berg, ... Proceedings of the National Academy of Sciences 110 (4), 1357-1362, 2013 | 303 | 2013 |
Dynamics of platelet thrombus formation SP Jackson, WS Nesbitt, E Westein Journal of thrombosis and Haemostasis 7, 17-20, 2009 | 287 | 2009 |
Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation MJ Maxwell, E Westein, WS Nesbitt, S Giuliano, SM Dopheide, ... Blood 109 (2), 566-576, 2007 | 280 | 2007 |
An experimental model to study the in vivo survival of von Willebrand factor: basic aspects and application to the R1205H mutation PJ Lenting, E Westein, V Terraube, AS Ribba, EG Huizinga, D Meyer, ... Journal of Biological Chemistry 279 (13), 12102-12109, 2004 | 200 | 2004 |
Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes MJ Kraakman, MKS Lee, A Al-Sharea, D Dragoljevic, TJ Barrett, ... The Journal of clinical investigation 127 (6), 2133-2147, 2017 | 186 | 2017 |
Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities A Rana, E Westein, B Niego, CE Hagemeyer Frontiers in cardiovascular medicine 6, 141, 2019 | 155 | 2019 |
A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood FJ Tovar-Lopez, G Rosengarten, E Westein, K Khoshmanesh, ... Lab on a Chip 10 (3), 291-302, 2010 | 155 | 2010 |
The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi M Ghasemzadeh, ZS Kaplan, I Alwis, SM Schoenwaelder, KJ Ashworth, ... Blood, The Journal of the American Society of Hematology 121 (22), 4555-4566, 2013 | 153 | 2013 |
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth A Ono, E Westein, S Hsiao, WS Nesbitt, JR Hamilton, SM Schoenwaelder, ... Blood, The Journal of the American Society of Hematology 112 (1), 90-99, 2008 | 152 | 2008 |
Mapping the collagen-binding site in the von Willebrand factor-A3 domain RA Romijn, E Westein, B Bouma, ME Schiphorst, JJ Sixma, PJ Lenting, ... Journal of Biological Chemistry 278 (17), 15035-15039, 2003 | 146 | 2003 |
Cysteine-mutations in von Willebrand factor associated with increased clearance CJ van Schooten, P Tjernberg, E Westein, V Terraube, G Castaman, ... Journal of Thrombosis and Haemostasis 3 (10), 2228-2237, 2005 | 121 | 2005 |
Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target A Straub, S Krajewski, JD Hohmann, E Westein, F Jia, N Bassler, C Selan, ... Arteriosclerosis, thrombosis, and vascular biology 31 (7), 1607-1616, 2011 | 101 | 2011 |
Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated … X Wang, J Palasubramaniam, Y Gkanatsas, JD Hohmann, E Westein, ... Circulation research 114 (7), 1083-1093, 2014 | 90 | 2014 |
Platelet recruitment to the inflamed glomerulus occurs via an αIIbβ3/GPVI-dependent pathway S Devi, MP Kuligowski, RYQ Kwan, E Westein, SP Jackson, AR Kitching, ... The American journal of pathology 177 (3), 1131-1142, 2010 | 80 | 2010 |
Multifunctional thrombin-activatable polymer capsules for specific targeting to activated platelets. ST Gunawan, K Kempe, T Bonnard, J Cui, K Alt, LS Law, X Wang, ... Advanced materials (Deerfield Beach, Fla.) 27 (35), 5153-5157, 2015 | 79 | 2015 |
LDL-receptor–related protein regulates β2-integrin–mediated leukocyte adhesion PPEM Spijkers, P da Costa Martins, E Westein, CG Gahmberg, ... Blood 105 (1), 170-177, 2005 | 78 | 2005 |
Monitoring in vitro thrombus formation with novel microfluidic devices E Westein, S de Witt, M Lamers, JMEM Cosemans, JWM Heemskerk Platelets 23 (7), 501-509, 2012 | 76 | 2012 |
A versatile approach for the site‐specific modification of recombinant antibodies using a combination of enzyme‐mediated bioconjugation and click chemistry K Alt, BM Paterson, E Westein, SE Rudd, SS Poniger, S Jagdale, ... Angewandte Chemie international edition 54 (26), 7515-7519, 2015 | 57 | 2015 |
Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: influence of glycosylation, proteolysis and gene mutations CM Millar, AF Riddell, SA Brown, R Starke, I Mackie, DJ Bowen, ... Thrombosis and haemostasis 99 (11), 916-924, 2008 | 57 | 2008 |