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Kun Xiong
Kun Xiong
Regeneron
Verified email at regeneron.com
Title
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Cited by
Year
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent
L Wang, Z Yang, J Fu, H Yin, K Xiong, Q Tan, H Jin, J Li, T Wang, W Tang, ...
Free Radical Biology and Medicine 52 (5), 898-908, 2012
1582012
Inhibition of thioredoxin reductase by a novel series of bis-1, 2-benzisoselenazol-3 (2H)-ones: Organoselenium compounds for cancer therapy
J He, D Li, K Xiong, Y Ge, H Jin, G Zhang, M Hong, Y Tian, J Yin, H Zeng
Bioorganic & medicinal chemistry 20 (12), 3816-3827, 2012
912012
Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy
L Wang, J Fu, J Wang, C Jin, X Ren, Q Tan, J Li, H Yin, K Xiong, T Wang, ...
Anti-Cancer Drugs 22 (8), 732-740, 2011
462011
Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M …
J Fu, J Li, Q Tan, H Yin, K Xiong, T Wang, X Ren, H Zeng
Investigational new drugs 29, 627-636, 2011
302011
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
J Rozowsky, J Gao, B Borsari, YT Yang, T Galeev, G Gursoy, CB Epstein, ...
Cell 186 (7), 1493-1511, 2023
182023
High transcriptional error rates vary as a function of gene expression level
KM Meer, PG Nelson, K Xiong, J Masel
Genome Biology and Evolution 12 (1), 3754-3761, 2020
162020
Drift barriers to quality control when genes are expressed at different levels
K Xiong, JP McEntee, DJ Porfirio, J Masel
Genetics 205 (1), 397-407, 2017
132017
Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity
H Yin, J Li, K Xiong, L Wang, T Wang, Q Tan, J Fu, X Ren, H Zeng
Differentiation 81 (1), 49-56, 2011
122011
Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise
K Xiong, AK Lancaster, ML Siegal, J Masel
Nature communications 10 (1), 2418, 2019
102019
Differences in evolutionary accessibility determine which equally effective regulatory motif evolves to generate pulses
K Xiong, M Gerstein, J Masel
Genetics 219 (3), iyab140, 2021
92021
Multi-tissue integrative analysis of personal epigenomes
J Rozowsky, J Drenkow, Y Yang, G Gursoy, T Galeev, B Borsari, ...
72021
Initiate tumors with single cell spheres formed in serum-containing medium
G Zhang, K Xiong, W Ma, W Xu, H Zeng
Journal of Cancer 6 (9), 901, 2015
52015
Reactive oxygen species mediate ethaselen-induced rapid apoptosis in A549 cells
K Xiong, W Xu, H Zeng
J Chin Pharm Sci 23, 54-9, 2014
42014
Non-adaptive factors determine which equally effective regulatory motif evolves to generate pulses
K Xiong, M Gerstein, J Masel
bioRxiv, 2020.12. 02.409151, 2020
12020
Comparing technological development and biological evolution from a network perspective
KK Yan, D Wang, K Xiong, M Gerstein
Cell Systems 10 (3), 219-222, 2020
12020
Drift barriers for the proofreading of genes expressed at different levels
K Xiong, JP McEntee, DJ Porfirio, J Masel
bioRxiv, 058453, 2016
12016
Assessing tissue-specific effects of rare and structural variants towards gene regulation with the EN-Tex personal genome resource
M Jensen, T Michaels, A Su, T Galeev, S Kumar, K Xiong, B Borsari, ...
EUROPEAN JOURNAL OF HUMAN GENETICS 32, 45-46, 2024
2024
The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models
J Rozowsky, J Drenkow, YT Yang, G Gursoy, T Galeev, B Borsari, ...
bioRxiv, 2021.04. 26.441442, 2021
2021
Adaptive and Non-Adaptive Evolution of the Control of Gene Expression
K Xiong
The University of Arizona, 2019
2019
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Articles 1–19