Luke Grundy
Luke Grundy
Head of Bladder Research, Visceral Pain Group, Flinders University
Verified email at
TitleCited byYear
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
JD Osteen, V Herzig, J Gilchrist, JJ Emrick, C Zhang, X Wang, J Castro, ...
Nature 534 (7608), 494, 2016
α-Conotoxin Vc1. 1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors
J Castro, AM Harrington, S Garcia-Caraballo, J Maddern, L Grundy, ...
Gut 66 (6), 1083-1094, 2017
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1
MC Inserra, MR Israel, A Caldwell, J Castro, JR Deuis, AM Harrington, ...
Scientific reports 7, 42810, 2017
NaV1. 1 inhibition can reduce visceral hypersensitivity
J Salvatierra, J Castro, A Erickson, Q Li, J Braz, J Gilchrist, L Grundy, ...
JCI insight 3 (11), 2018
Visceral pain
L Grundy, A Erickson, SM Brierley
Annual review of physiology, 2019
Voltage‐gated sodium channels:(NaV) igating the field to determine their contribution to visceral nociception
A Erickson, A Deiteren, AM Harrington, S Garcia‐Caraballo, J Castro, ...
The Journal of physiology 596 (5), 785-807, 2018
Cyclic analogues of α‐conotoxin Vc1. 1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain
J Castro, L Grundy, A Deiteren, AM Harrington, T O'Donnell, J Maddern, ...
British journal of pharmacology 175 (12), 2384-2398, 2018
TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder
L Grundy, DM Daly, C Chapple, D Grundy, R Chess-Williams
Scientific reports 8 (1), 197, 2018
Cross-organ sensitization between the colon and bladder: to pee or not to pee?
L Grundy, SM Brierley
American Journal of Physiology-Gastrointestinal and Liver Physiology 314 (3 …, 2017
The validation of an invitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions
C Keating, V Martinez, L Ewart, S Gibbons, L Grundy, JP Valentin, ...
Toxicology and applied pharmacology 245 (3), 299-309, 2010
Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice
NJ Spencer, S Greenheigh, M Kyloh, TJ Hibberd, H Sharma, L Grundy, ...
Journal of Comparative Neurology 526 (4), 707-720, 2018
Contribution of membrane receptor signalling to chronic visceral pain
M Sadeghi, A Erickson, J Castro, A Deiteren, AM Harrington, L Grundy, ...
The international journal of biochemistry & cell biology 98, 10-23, 2018
NKA enhances bladder-afferent mechanosensitivity via urothelial and detrusor activation
L Grundy, R Chess-Williams, SM Brierley, K Mills, KH Moore, K Mansfield, ...
American Journal of Physiology-Renal Physiology 315 (4), F1174-F1185, 2018
Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension
L Grundy, A Erickson, A Caldwell, S Garcia-Caraballo, G Rychkov, ...
Pain 159 (12), 2573-2584, 2018
Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction
L Grundy, AM Harrington, J Castro, S Garcia-Caraballo, A Deiteren, ...
JCI insight 3 (19), 2018
Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials
C Keating, L Ewart, L Grundy, JP Valentin, D Grundy
Neurogastroenterology & Motility 26 (7), 980-989, 2014
Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome
L Grundy, A Caldwell, S Brierley
Frontiers in neuroscience 12, 931, 2018
561 chronic oral administration of the guanylate cyclase-C agonist linaclotide attenuates colitis induced bladder afferent hyperactivity
LA Grundy, S Garcia-Carraballo, J Maddern, G Rychkov, G Hannig, ...
Gastroenterology 150 (4), S118-S119, 2016
Serotonin exerts a direct modulatory role on bladder afferent firing in mice
N Konthapakdee, L Grundy, T O'Donnell, S Garcia‐Caraballo, SM Brierley, ...
The Journal of physiology, 2019
Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord.
AM Harrington, S Garcia Caraballo, JE Maddern, L Grundy, J Castro, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2019
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