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Shailesh Natvarbhai Mistry
Shailesh Natvarbhai Mistry
Associate Professor of Medicinal Chemistry, University of Nottingham
Verified email at nottingham.ac.uk - Homepage
Title
Cited by
Cited by
Year
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
AE Cook, SN Mistry, KJ Gregory, SGB Furness, PM Sexton, PJ Scammells, ...
British journal of pharmacology 172 (1), 185-200, 2015
862015
Synthesis and Pharmacological Profiling of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) as Allosteric Modulators of the M1 Muscarinic Receptor
SN Mistry, C Valant, PM Sexton, B Capuano, A Christopoulos, ...
Journal of medicinal chemistry 56 (12), 5151-5172, 2013
752013
Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor
A Abdul-Ridha, L Lopez, P Keov, DM Thal, SN Mistry, PM Sexton, ...
Journal of Biological Chemistry 289 (9), 6067-6079, 2014
732014
Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
A Abdul-Ridha, JR Lane, SN Mistry, L Lopez, PM Sexton, PJ Scammells, ...
Journal of Biological Chemistry 289 (48), 33701-33711, 2014
632014
Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors
SN Mistry, N Drinkwater, C Ruggeri, KK Sivaraman, S Loganathan, ...
Journal of medicinal chemistry 57 (21), 9168-9183, 2014
632014
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions
N Drinkwater, NB Vinh, SN Mistry, RS Bamert, C Ruggeri, JP Holleran, ...
European journal of medicinal chemistry 110, 43-64, 2016
592016
Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand
SN Mistry, J Shonberg, CJ Draper-Joyce, C Klein Herenbrink, M Michino, ...
Journal of medicinal chemistry 58 (17), 6819-6843, 2015
542015
Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors
JG Baker, LA Adams, K Salchow, SN Mistry, RJ Middleton, SJ Hill, ...
Journal of medicinal chemistry 54 (19), 6874-6887, 2011
502011
Structure–Activity Study of N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a Bitopic Ligand That Acts as a …
J Shonberg, C Draper-Joyce, SN Mistry, A Christopoulos, PJ Scammells, ...
Journal of Medicinal Chemistry 58 (13), 5287-5307, 2015
452015
Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa
F Soukarieh, R Liu, M Romero, SN Roberston, W Richardson, S Lucanto, ...
Frontiers in Chemistry 8, 204, 2020
402020
Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18
A Paiardini, RS Bamert, K Kannan-Sivaraman, N Drinkwater, SN Mistry, ...
PloS one 10 (2), e0115859, 2015
402015
A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor
TJ Fyfe, B Zarzycka, HD Lim, B Kellam, SN Mistry, V Katrich, ...
Journal of Medicinal Chemistry 62 (1), 174-206, 2018
382018
4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor
SN Mistry, M Jörg, H Lim, NB Vinh, PM Sexton, B Capuano, ...
Journal of Medicinal Chemistry 59 (1), 388-409, 2016
372016
Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior
KHC Choy, DM Shackleford, DT Malone, SN Mistry, RT Patil, ...
Journal of Pharmacology and Experimental Therapeutics 359 (2), 354-365, 2016
272016
Synthesis and in Vitro and in Vivo Characterization of Highly β1-Selective β-Adrenoceptor Partial Agonists
SN Mistry, JG Baker, PM Fischer, SJ Hill, SM Gardiner, B Kellam
Journal of Medicinal Chemistry 56 (10), 3852-3865, 2013
272013
Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease
JG Baker, SM Gardiner, J Woolard, C Fromont, GP Jadhav, SN Mistry, ...
The FASEB Journal 31 (7), 3150, 2017
192017
Structure–Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor
TJ Fyfe, B Kellam, DA Sykes, B Capuano, PJ Scammells, JR Lane, ...
Journal of Medicinal Chemistry 62 (21), 9488-9520, 2019
142019
Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor
SN Mistry, H Lim, M Jörg, B Capuano, A Christopoulos, JR Lane, ...
ACS Chemical Neuroscience 7 (5), 647-661, 2016
142016
Assessment of the molecular mechanisms of action of novel 4-Phenylpyridine-2-one and 6-Phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors
ET van der Westhuizen, A Spathis, E Khajehali, M Jörg, SN Mistry, ...
Molecular Pharmacology 94 (1), 770-783, 2018
122018
GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors
AL Emtage, SN Mistry, PM Fischer, B Kellam, CA Laughton
Journal of Biomolecular Structure and Dynamics 35 (12), 2604-2619, 2017
72017
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