Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength MS Ominsky, F Vlasseros, J Jolette, SY Smith, B Stouch, G Doellgast, ... Journal of Bone and Mineral Research 25 (5), 948-959, 2010 | 540 | 2010 |
Structure and interactions of the human programmed cell death 1 receptor X Cheng, V Veverka, A Radhakrishnan, LC Waters, FW Muskett, ... Journal of Biological Chemistry 288 (17), 11771-11785, 2013 | 350 | 2013 |
Characterization of the structural features and interactions of sclerostin V Veverka, AJ Henry, PM Slocombe, A Ventom, B Mulloy, FW Muskett, ... Journal of Biological Chemistry 284 (16), 10890-10900, 2009 | 287 | 2009 |
The crystal structure of IgE Fc reveals an asymmetrically bent conformation T Wan, RL Beavil, SM Fabiane, AJ Beavil, MK Sohi, M Keown, RJ Young, ... Nature immunology 3 (7), 681-686, 2002 | 213 | 2002 |
Sclerostin-binding antibody C Paszty, MK Robinson, K Graham, AJ Henry, KS Hoffmann, J Latham, ... US Patent 7,592,429, 2009 | 159 | 2009 |
Participation of the N-terminal region of Cε3 in the binding of human IgE to its high-affinity receptor FcεRI AJ Henry, JPD Cook, JM McDonnell, GA Mackay, J Shi, BJ Sutton, ... Biochemistry 36 (50), 15568-15578, 1997 | 142 | 1997 |
The structure of the IgE Cɛ2 domain and its role in stabilizing the complex with its high-affinity receptor FcɛRIα JM McDonnell, R Calvert, RL Beavil, AJ Beavil, AJ Henry, BJ Sutton, ... Nature structural biology 8 (5), 437-441, 2001 | 118 | 2001 |
Dynamics of intact immunoglobulin G explored by drift‐tube ion‐mobility mass spectrometry and molecular modeling KJ Pacholarz, M Porrini, RA Garlish, RJ Burnley, RJ Taylor, AJ Henry, ... Angewandte Chemie International Edition 53 (30), 7765-7769, 2014 | 112 | 2014 |
Upregulation of FcϵRI on human basophils by IgE antibody is mediated by interaction of IgE with FcϵRI D MacGlashan Jr, LM Lichtenstein, J McKenzie-White, K Chichester, ... Journal of allergy and clinical immunology 104 (2), 492-498, 1999 | 106 | 1999 |
Epitopes M Robinson, A Henry, A Lawson, H Lu, C Paszty, K Hoffmann, J Latham, ... US Patent App. 11/410,540, 2007 | 104 | 2007 |
Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI B Dhaliwal, D Yuan, MOY Pang, AJ Henry, K Cain, A Oxbrow, ... Proceedings of the National Academy of Sciences 109 (31), 12686-12691, 2012 | 98 | 2012 |
A tumor-associated β1 integrin mutation that abrogates epithelial differentiation control RD Evans, VC Perkins, A Henry, PE Stephens, MK Robinson, FM Watt The Journal of cell biology 160 (4), 589-596, 2003 | 98 | 2003 |
Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling S Shaw, T Bourne, C Meier, B Carrington, R Gelinas, A Henry, ... MAbs 6 (3), 773-781, 2014 | 96 | 2014 |
Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors G Holdsworth, P Slocombe, C Doyle, B Sweeney, V Veverka, K Le Riche, ... Journal of Biological Chemistry 287 (32), 26464-26477, 2012 | 94 | 2012 |
Identification of contact residues in the IgE binding site of human FcεRIα JPD Cook, AJ Henry, JM McDonnell, RJ Owens, BJ Sutton, HJ Gould Biochemistry 36 (50), 15579-15588, 1997 | 91 | 1997 |
Automated protein–ligand interaction screening by mass spectrometry HJ Maple, RA Garlish, L Rigau-Roca, J Porter, I Whitcombe, CE Prosser, ... Journal of Medicinal Chemistry 55 (2), 837-851, 2012 | 81 | 2012 |
Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab AM Davies, EG Allan, AH Keeble, J Delgado, BP Cossins, AN Mitropoulou, ... Journal of Biological Chemistry 292 (24), 9975-9987, 2017 | 73 | 2017 |
Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability SJ Peters, CM Smales, AJ Henry, PE Stephens, S West, DP Humphreys Journal of Biological Chemistry 287 (29), 24525-24533, 2012 | 73 | 2012 |
Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering DP Humphreys, SP Heywood, A Henry, L Ait-Lhadj, P Antoniw, ... Protein Engineering, Design & Selection 20 (5), 227-234, 2007 | 69 | 2007 |
Secretion of recombinant human IgE-Fc by mammalian cells and biological activity of glycosylation site mutants RJ Young, RJ Owens, GA Mackay, CMW Chan, J Shi, M Hide, DM Francis, ... Protein Engineering, Design and Selection 8 (2), 193-199, 1995 | 69 | 1995 |