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Jason Z Zhang
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Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling
JZ Zhang, TW Lu, LM Stolerman, B Tenner, JR Yang, JF Zhang, M Falcke, ...
Cell 182 (6), 1531-1544. e15, 2020
1992020
De novo design of luciferases using deep learning
AHW Yeh, C Norn, Y Kipnis, D Tischer, SJ Pellock, D Evans, P Ma, ...
Nature 614 (7949), 774-780, 2023
1582023
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice
JF Zhang*, B Liu*, I Hong*, A Mo, RH Roth, B Tenner, W Lin, JZ Zhang, ...
Nature chemical biology 17 (1), 39-46, 2021
592021
Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture
JZ Zhang, S Mehta, J Zhang
Trends in pharmacological sciences 42 (10), 845-856, 2021
302021
Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants
JZ Zhang*, HW Yeh*, AC Walls, BIM Wicky, KR Sprouse, LA VanBlargan, ...
Nature Biotechnology, 1-5, 2022
222022
FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains
B Tenner*, JZ Zhang*, Y Kwon, V Pessino, S Feng, B Huang, S Mehta, ...
Science Advances 7 (21), eabe4091, 2021
212021
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling
JZ Zhang, AH Nguyen, S Miyamoto, J Heller Brown, AD McCulloch, ...
PLoS Biology 18 (9), e3000866, 2020
62020
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, R Wang, ...
BioRxiv, 2023
52023
Characterizing protein kinase A (PKA) subunits as macromolecular regulators of PKA RI α liquid–liquid phase separation
SH Ahn*, S Qin*, JZ Zhang, JA McCammon, J Zhang, HX Zhou
The Journal of Chemical Physics 154 (22), 221101, 2021
52021
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
JZ Zhang, WH Nguyen, N Greenwood, JC Rose, SE Ong, DJ Maly, ...
Nature Biotechnology, 1-11, 2024
3*2024
De novo designed Hsp70 activator dissolves intracellular condensates
JZ Zhang, N Greenwood, J Hernandez, JT Cuperus, B Huang, BD Ryder, ...
bioRxiv, 2023
12023
Protocol for using fluorescent sensors targeted to endogenous proteins (FluoSTEPs) to measure microdomain-specific signaling events
JZ Zhang, B Tenner, S Mehta, J Zhang
STAR protocols 2 (3), 100693, 2021
12021
Automated, miniaturized, and scalable screening of healthcare workers, first responders, and students for SARS-CoV-2 in San Diego County
SC Morgan, S Aigner, C Anderson, P Belda-Ferre, P De Hoff, CA Marotz, ...
medRxiv, 2021.06. 25.21257885, 2021
12021
Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance
JZ Zhang, SE Ong, D Baker, DJ Maly
bioRxiv, 2023
2023
Computational design of non-porous, pH-responsive antibody nanoparticles
EC Yang, R Divine, MC Miranda, AJ Borst, W Sheffler, JZ Zhang, ...
bioRxiv, 2023
2023
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