| Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective M Seifert, SC Bera, P Van Nies, RN Kirchdoerfer, A Shannon, TTN Le, ... Elife 10, e70968, 2021 | 60 | 2021 |
| Alkyl 4-chlorobenzoyloxycarbamates as highly effective nitrogen source reagents for the base-free, intermolecular aminohydroxylation reaction L Harris, SPH Mee, RH Furneaux, GJ Gainsford, A Luxenburger The Journal of organic chemistry 76 (2), 358-372, 2011 | 60 | 2011 |
| Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis TV Pham, AS Murkin, MM Moynihan, L Harris, PC Tyler, N Shetty, ... Proceedings of the National Academy of Sciences 114 (29), 7617-7622, 2017 | 47 | 2017 |
| Substituted diaryldiazomethanes and diazofluorenes: structure, reactivity and stability PJ Davis, L Harris, A Karim, AL Thompson, M Gilpin, MG Moloney, ... Tetrahedron letters 52 (14), 1553-1556, 2011 | 45 | 2011 |
| Synthesis and use of a trifluoromethylated azomethine ylide precursor G Tran, R Meier, L Harris, DL Browne, SV Ley The Journal of Organic Chemistry 77 (24), 11071-11078, 2012 | 39 | 2012 |
| E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function TD Godwin, ST Kelly, TP Brew, NM Bougen-Zhukov, AB Single, A Chen, ... Gastric Cancer 22, 273-286, 2019 | 36 | 2019 |
| Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases Y Zhang, GB Evans, K Clinch, DR Crump, LD Harris, RFG Fröhlich, ... Journal of Biological Chemistry 288 (48), 34746-34754, 2013 | 33 | 2013 |
| A designed approach to enantiodivergent enamine catalysis J Macharia, V Wambua, Y Hong, L Harris, JS Hirschi, GB Evans, ... Angewandte Chemie 129 (30), 8882-8886, 2017 | 32 | 2017 |
| Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication JCC Hsu, M Laurent-Rolle, JB Pawlak, H Xia, A Kunte, JS Hee, J Lim, ... Molecular cell 82 (9), 1631-1642. e6, 2022 | 21 | 2022 |
| Chemical synthesis of the antiviral nucleotide analogue ddhCTP JM Wood, GB Evans, TL Grove, SC Almo, SA Cameron, RH Furneaux, ... The Journal of Organic Chemistry 86 (13), 8843-8850, 2021 | 14 | 2021 |
| Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: access to annulated prolines L Harris, M Gilpin, AL Thompson, AR Cowley, MG Moloney Organic & Biomolecular Chemistry 13 (23), 6522-6550, 2015 | 14 | 2015 |
| Signatures and mechanisms of efficacious therapeutic ribonucleotides against SARS-CoV-2 revealed by analysis of its replicase using magnetic tweezers M Seifert, SC Bera, P van Nies, RN Kirchdoerfer, A Shannon, X Meng, ... | 13 | 2020 |
| Narrow-spectrum antibiotic targeting of the radical SAM enzyme MqnE in menaquinone biosynthesis AG Carl, LD Harris, M Feng, LU Nordstrøm, GJ Gerfen, GB Evans, ... Biochemistry 59 (27), 2562-2575, 2020 | 11 | 2020 |
| Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists EM Ure, LD Harris, SA Cameron, A Weymouth-Wilson, RH Furneaux, ... Organic & Biomolecular Chemistry 20 (17), 3511-3527, 2022 | 7 | 2022 |
| A novel class of azatricyclononanes: pentasubstituted cyclopropanes from an uncatalysed reaction L Harris, M Gilpin, AL Thompson, AR Cowley, MG Moloney Tetrahedron: Asymmetry 20 (6-8), 726-729, 2009 | 7 | 2009 |
| Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid DM Mellott, D Torres, IV Krieger, SA Cameron, Z Moghadamchargari, ... Journal of the American Chemical Society 143 (42), 17666-17676, 2021 | 6 | 2021 |
| The post-lockdown period should be used to acquire effective therapies for future resurgence in SARS-Cov-2 infections. KL Krause, R Furneaux, P Benjes, M Brimble, T Davidson, W Denny, ... | 6 | 2020 |
| Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase LD Harris, RK Harijan, RG Ducati, GB Evans, BM Hirsch, VL Schramm ACS chemical biology 13 (1), 152-160, 2018 | 6 | 2018 |
| Synthesis of 12β-Methyl-18-nor-bile Acids A Luxenburger, LD Harris, EM Ure, RA Landaeta Aponte, AD Woolhouse, ... ACS omega 6 (38), 25019-25039, 2021 | 5 | 2021 |
| Discovery of AL-GDa62 as a potential synthetic lethal lead for the treatment of gastric cancer A Luxenburger, N Bougen-Zhukov, MG Fraser, H Beetham, LD Harris, ... Journal of Medicinal Chemistry 64 (24), 18114-18142, 2021 | 4 | 2021 |
