| Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily SE Tsutakawa, S Classen, BR Chapados, AS Arvai, LD Finger, ... Cell 145 (2), 198-211, 2011 | 317 | 2011 |
| The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT) R Lu, JJ O’Rourke, AP Sobinoff, JAM Allen, CB Nelson, CG Tomlinson, ... Nature communications 10 (1), 2252, 2019 | 146 | 2019 |
| Substrate recognition and catalysis by flap endonucleases and related enzymes CG Tomlinson, JM Atack, B Chapados, JA Tainer, JA Grasby Biochemical Society Transactions 38 (2), 433-437, 2010 | 65 | 2010 |
| A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution BP Paudel, AL Moye, H Abou Assi, R El-Khoury, SB Cohen, JK Holien, ... Elife 9, e56428, 2020 | 51 | 2020 |
| A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase A Killedar, MD Stutz, AP Sobinoff, CG Tomlinson, TM Bryan, J Beesley, ... PLoS genetics 11 (6), e1005286, 2015 | 47 | 2015 |
| Three metal ions participate in the reaction catalyzed by T5 flap endonuclease K Syson, C Tomlinson, BR Chapados, JR Sayers, JA Tainer, NH Williams, ... Journal of biological chemistry 283 (42), 28741-28746, 2008 | 47 | 2008 |
| Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates B Sengerová, C Tomlinson, JM Atack, R Williams, JR Sayers, NH Williams, ... Biochemistry 49 (37), 8085-8093, 2010 | 30 | 2010 |
| Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding CG Tomlinson, AL Moye, JK Holien, MW Parker, SB Cohen, TM Bryan Biochemical Journal 465 (2), 347-357, 2015 | 21 | 2015 |
| Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions CG Tomlinson, K Syson, B Sengerová, JM Atack, JR Sayers, L Swanson, ... Journal of Biological Chemistry 286 (35), 30878-30887, 2011 | 19 | 2011 |
| Quantitative assays for measuring human telomerase activity and DNA binding properties CG Tomlinson, N Sasaki, J Jurczyluk, TM Bryan, SB Cohen Methods 114, 85-95, 2017 | 17 | 2017 |
| The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA CG Tomlinson, JK Holien, JAT Mathias, MW Parker, TM Bryan Biochimie 128, 114-121, 2016 | 12 | 2016 |
| Three metal ions participate in T5 flap endonuclease catalysed DNA hydrolysis K Syson, C Tomlinson, BR Chapados, JR Sayers, JA Tainer, NH Williams, ... J. Biol. Chem 283, 28741-28746, 2008 | 8 | 2008 |
| Clinical and functional characterization of telomerase variants in patients with pediatric acute myeloid leukemia/myelodysplastic syndrome CG Tomlinson, G Sasa, G Aubert, B Martin-Giacalone, SE Plon, TM Bryan, ... Leukemia 35 (1), 269-273, 2021 | 6 | 2021 |
| The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation CB Nelson, S Rogers, K Roychoudhury, YS Tan, CJ Atkinson, AP Sobinoff, ... Nature Communications 15 (1), 1385, 2024 | 1 | 2024 |
| Quantitative assays for measuring human telomerase activity and DNA binding properties T Bryan, S Cohen, J Jurczyluk, N Sasaki, C Tomlinson Academic Press, 2017 | | 2017 |
| A CANCER RISK-ASSOCIATED POLYMORPHISM IN THE TERT LOCUS ENCODES A NOVEL SPLICE VARIANT WHICH IS A DOMINANT NEGATIVE INHIBITOR OF TELOMERASE A Killedar, MD Stutz, AP Sobinoff, CG Tomlinson, J Beesley, ... ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 10, 40-40, 2014 | | 2014 |
