Wei Wen Lim
Wei Wen Lim
National Heart Centre Singapore, Duke-NUS Medical School
Verified email at
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IL-11 is a crucial determinant of cardiovascular fibrosis
S Schafer, S Viswanathan, AA Widjaja, WW Lim, A Moreno-Moral, ...
Nature 552 (7683), 110-115, 2017
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
B Ng, J Dong, G D’Agostino, S Viswanathan, AA Widjaja, WW Lim, ...
Science translational medicine 11 (511), eaaw1237, 2019
Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis
AA Widjaja, BK Singh, E Adami, S Viswanathan, J Dong, GA D’Agostino, ...
Gastroenterology 157 (3), 777-792. e14, 2019
Bipolar electrogram shannon entropy at sites of rotational activation: implications for ablation of atrial fibrillation
AN Ganesan, P Kuklik, DH Lau, AG Brooks, M Baumert, WW Lim, ...
Circulation: Arrhythmia and Electrophysiology 6 (1), 48-57, 2013
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
J Dong, S Viswanathan, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, ...
Nature communications 12 (1), 66, 2021
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury
AA Widjaja, J Dong, E Adami, S Viswanathan, B Ng, LS Pakkiri, ...
Science translational medicine 13 (597), eaba8146, 2021
A high-resolution map of human RNA translation
SP Chothani, E Adami, AA Widjaja, SR Langley, S Viswanathan, CJ Pua, ...
Molecular cell 82 (15), 2885-2899. e8, 2022
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
WW Lim, B Ng, A Widjaja, C Xie, L Su, N Ko, SY Lim, XY Kwek, S Lim, ...
PLoS One 15 (1), e0227505, 2020
Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
WW Lim, B Corden, B Ng, K Vanezis, G D’Agostino, AA Widjaja, WH Song, ...
Scientific reports 10 (1), 17853, 2020
IL11 stimulates IL33 expression and proinflammatory fibroblast activation across tissues
AA Widjaja, S Chothani, S Viswanathan, JWT Goh, WW Lim, SA Cook
International Journal of Molecular Sciences 23 (16), 8900, 2022
Inhibition of IL11 signaling reduces aortic pathology in murine marfan syndrome
WW Lim, J Dong, B Ng, AA Widjaja, C Xie, L Su, XY Kwek, NGZ Tee, ...
Circulation Research 130 (5), 728-740, 2022
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
AA Widjaja, S Viswanathan, JGW Ting, J Tan, SG Shekeran, D Carling, ...
IScience 25 (8), 2022
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
AA Widjaja, S Viswanathan, SG Shekeran, E Adami, WW Lim, S Chothani, ...
Nature Communications 13 (1), 7497, 2022
IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis
B Ng, S Viswanathan, AA Widjaja, WW Lim, SG Shekeran, JWT Goh, ...
International Journal of Molecular Sciences 23 (7), 3549, 2022
Therapeutic targeting of interleukin-11 signalling reduces pressure overload–induced cardiac fibrosis in mice
B Corden, WW Lim, W Song, X Chen, NSJ Ko, L Su, NGZ Tee, E Adami, ...
Journal of Cardiovascular Translational Research 14, 222-228, 2021
Antibody‐mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload
WW Lim, B Corden, L Ye, S Viswanathan, AA Widjaja, C Xie, L Su, ...
Clinical and Experimental Pharmacology and Physiology 48 (4), 605-613, 2021
Electrophysiological and structural remodeling of the atria in a mouse model of troponin-I mutation linked hypertrophic cardiomyopathy: implications for atrial fibrillation
WW Lim, M Neo, S Thanigaimani, P Kuklik, AN Ganesan, DH Lau, ...
International Journal of Molecular Sciences 22 (13), 6941, 2021
Interleukin-11: a potential biomarker and molecular therapeutic target in non-small cell lung cancer
JH Leung, B Ng, WW Lim
Cells 11 (14), 2257, 2022
Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction
M Sweeney, K O’Fee, C Villanueva-Hayes, E Rahman, M Lee, K Vanezis, ...
International Journal of Molecular Sciences 24 (16), 12989, 2023
Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy
WW Lim, M Baumert, M Neo, P Kuklik, AN Ganesan, DH Lau, ...
Clinical and Experimental Pharmacology and Physiology 43 (1), 95-101, 2016
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