| A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA. AL Perryman, W Yu, X Wang, S Ekins, S Forli, SG Li, JS Freundlich, ... J. Chem. Inf. Model 55 (3), 645–659, 2015 | 44 | 2015 |
| Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium … J Stec, C Vilchze, S Lun, A Perryman, X Wang, JS Freundlich, W Bishai, ... ChemMedChem. 9 (11), 2528-37, 2014 | 34 | 2014 |
| Tuberculosis treatment failure associated with evolution of antibiotic resilience Q Liu, J Zhu, CL Dulberger, S Stanley, S Wilson, ES Chung, X Wang, ... Science 378 (6624), 1111-1118, 2022 | 30 | 2022 |
| Morphological profiling of tubercle bacilli identifies drug pathways of action TC Smith, KM Pullen, MC Olson, ME McNellis, I Richardson, S Hu, ... Proceedings of the National Academy of Sciences 117 (31), 18744-18753, 2020 | 30 | 2020 |
| Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights SG Li, C Vilchèze, S Chakraborty, X Wang, H Kim, M Anisetti, S Ekins, ... Tetrahedron Lett. 56 (23), 3246-3250, 2015 | 30 | 2015 |
| Antitubercular Triazines: Optimization and Intrabacterial Metabolism X Wang, D Inoyama, R Russo, SG Li, R Jadhav, TP Stratton, N Mittal, ... Cell Chemical Biology 27 (2), 172-185. e11, 2020 | 26 | 2020 |
| A preclinical candidate targeting Mycobacterium tuberculosis KasA D Inoyama, D Awasthi, GC Capodagli, K Tsotetsi, P Sukheja, ... Cell chemical biology 27 (5), 560-570. e10, 2020 | 23 | 2020 |
| Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery S Ekins, PB Madrid, M Sarker, SG Li, N Mittal, P Kumar, X Wang, ... PLos One. 10 (10), e0141076, 2015 | 21 | 2015 |
| Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis X Wang, AL Perryman, SG Li, SD Paget, TP Stratton, A Lemenze, ... ACS Infectious Diseases 5 (12), 2148-2163, 2019 | 18 | 2019 |
| Multiplexed strain phenotyping defines consequences of genetic diversity in Mycobacterium tuberculosis for infection and vaccination outcomes AF Carey, X Wang, N Cicchetti, CN Spaulding, Q Liu, F Hopkins, J Brown, ... Msystems 7 (3), e00110-22, 2022 | 7 | 2022 |
| Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae JC Pereira, SS Daher, KM Zorn, M Sherwood, R Russo, AL Perryman, ... Pharmaceutical research 37, 1-10, 2020 | 7 | 2020 |
| High-throughput phenogenotyping of Mycobacteria tuberculosis clinical strains reveals bacterial determinants of treatment outcomes S Stanley, CN Spaulding, Q Liu, MR Chase, DTM Ha, PVK Thai, NH Lan, ... bioRxiv, 2023 | 1 | 2023 |
| Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model X Wang, H Su, JB Wallach, JC Wagner, BJ Braunecker, M Gardner, ... bioRxiv, 2023.11. 19.567569, 2023 | 1 | 2023 |
| Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis C Levine, R Jadhav, Y Pan, K Tsotetsi, X Wang, D Awasthi, C Grady, ... bioRxiv, 2022.07. 05.496887, 2022 | 1 | 2022 |
| Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure S Stanley, X Wang, Q Liu, YY Kwon, AM Frey, ND Hicks, AJ Vickers, S Hui, ... PLoS pathogens 20 (2), e1012050, 2024 | | 2024 |
| Antitubercular drug discovery enabled by Bayesian modeling A Perryman, T Stratton, J Patel, X Wang, S Ekins, J Freundlich ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |
| Novel antibacterial chemical tools through machine learning J Patel, X Wang, A Perryman, S Kandasamy, S Ekins, J Freundlich ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254, 2017 | | 2017 |
| Metabolomics-aided optimization of antitubercular thienopyrimidines SG Li, C Vilcheze, S Chakraborty, X Wang, H Kim, M Anisetti, S Ekins, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
| Novel, cell-trained approach to biological target-guided chemical tools and its application to Mycobacterium tuberculosis A Perryman, X Wang, SG Li, S Paget, T Stratton, A Olson, S Ekins, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
| Novel inhibitors of M. tuberculosis InhA: A little learning can go a long way T Stratton, A Perryman, X Wang, SG Li, S Paget, A Olson, S Ekins, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
