Loretta Dorstyn

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Claire WilsonNHMRC Early Career Research FellowVerified email at unisa.edu.au
Helena E. RichardsonAssociate Professor of Biochemistry & Genetics at La Trobe University, Melbourne, AustraliaVerified email at latrobe.edu.au
Yoon LimCentre for Cancer Biology, University of South AustraliaVerified email at unisa.edu.au
BAOLI YANG, MD, PhDUNIVERSITY OF IOWAVerified email at uiowa.edu
dimitrios cakourosuniversity of adelaideVerified email at adelaide.edu.au
Seong-Seng TanUniversity of MelbourneVerified email at florey.edu.au
Devendra HiwaseRoyal Adelaide Hospital, South Australia Health and Medical Research InstituteVerified email at sa.gov.au
Natalie FootUniversity of AdelaideVerified email at adelaide.edu.au
Jarrod SandowThe Walter and Eliza Hall InstituteVerified email at wehi.edu.au
John SilkeProfessor, The Walter and Eliza Hall InstituteVerified email at latrobe.edu.au
Jason HowittSwinburne University of Technology; Florey Institute of Neuroscience and Mental HelathVerified email at florey.edu.au
Martin LavinVerified email at uq.edu.au
Jillian CarrFlinders UniversityVerified email at flinders.edu.au

Loretta Dorstyn

Centre for Cancer Biology, University of South Australia

Verified email at unisa.edu.au - Homepage

Molecular and Cell Biology - cell death genomic instability tumorigenesis


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Old, new and emerging functions of caspases S Shalini, L Dorstyn, S Dawar, S Kumar Cell Death & Differentiation 22 (4), 526-539, 2015	1353	2015
DRONC, an ecdysone-inducible Drosophila caspase L Dorstyn, PA Colussi, LM Quinn, H Richardson, S Kumar Proceedings of the National Academy of Sciences 96 (8), 4307-4312, 1999	346	1999
The role of cytochrome c in caspase activation in Drosophila melanogaster cells L Dorstyn, S Read, D Cakouros, JR Huh, BA Hay, S Kumar The Journal of cell biology 156 (6), 1089-1098, 2002	238	2002
An essential role for the caspase dronc in developmentally programmed cell death in Drosophila LM Quinn, L Dorstyn, K Mills, PA Colussi, P Chen, M Coombe, J Abrams, ... Journal of Biological Chemistry 275 (51), 40416-40424, 2000	195	2000
New insights into apoptosome structure and function L Dorstyn, CW Akey, S Kumar Cell Death & Differentiation 25 (7), 1194-1208, 2018	188	2018
A tumor suppressor function for caspase-2 LH Ho, R Taylor, L Dorstyn, D Cakouros, P Bouillet, S Kumar Proceedings of the National Academy of Sciences 106 (13), 5336-5341, 2009	186	2009
DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7 L Dorstyn, SH Read, LM Quinn, H Richardson, S Kumar Journal of Biological Chemistry 274 (43), 30778-30783, 1999	166	1999
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells L Dorstyn, K Mills, Y Lazebnik, S Kumar The Journal of Cell Biology 167 (3), 405-410, 2004	149	2004
Caspase-2 is required for cell death induced by cytoskeletal disruption LH Ho, SH Read, L Dorstyn, L Lambrusco, S Kumar Oncogene 27 (24), 3393-3404, 2008	141	2008
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2 NJ Foot, HE Dalton, LM Shearwin-Whyatt, L Dorstyn, SS Tan, B Yang, ... Blood, The Journal of the American Society of Hematology 112 (10), 4268-4275, 2008	139	2008
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons J Howitt, U Putz, J Lackovic, A Doan, L Dorstyn, H Cheng, B Yang, ... Proceedings of the National Academy of Sciences 106 (36), 15489-15494, 2009	125	2009
Characterization of the DrosophilaCaspase, DAMM NL Harvey, T Daish, K Mills, L Dorstyn, LM Quinn, SH Read, ... Journal of Biological Chemistry 276 (27), 25342-25350, 2001	110	2001
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability L Dorstyn, J Puccini, CH Wilson, S Shalini, M Nicola, S Moore, S Kumar Cell Death & Differentiation 19 (8), 1288-1298, 2012	105	2012
Caspase-2 as a tumour suppressor J Puccini, L Dorstyn, S Kumar Cell Death & Differentiation 20 (9), 1133-1139, 2013	102	2013
Structure of the Drosophila apoptosome at 6.9 Å resolution S Yuan, X Yu, M Topf, L Dorstyn, S Kumar, SJ Ludtke, CW Akey Structure 19 (1), 128-140, 2011	98	2011
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice S Shalini, L Dorstyn, C Wilson, J Puccini, L Ho, S Kumar Cell Death & Differentiation 19 (8), 1370-1380, 2012	88	2012
Caspase-2-mediated cell death is required for deleting aneuploid cells S Dawar, Y Lim, J Puccini, M White, P Thomas, L Bouchier-Hayes, ... Oncogene 36 (19), 2704-2714, 2017	70	2017
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice J Puccini, S Shalini, AK Voss, M Gatei, CH Wilson, DK Hiwase, MF Lavin, ... Proceedings of the National Academy of Sciences 110 (49), 19920-19925, 2013	69	2013
A biochemical analysis of the activation of the Drosophila caspase DRONC L Dorstyn, S Kumar Cell Death & Differentiation 15 (3), 461-470, 2008	68	2008
ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis JJ Sandow, L Dorstyn, LA O'reilly, M Tailler, S Kumar, A Strasser, ... Cell Death & Differentiation 21 (3), 475-480, 2014	64	2014

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