mark paine
mark paine
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Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the …
MJ Paine, HP Desmond, RD Theakston, JM Crampton
Journal of Biological Chemistry 267 (32), 22869-22876, 1992
Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids
P Müller, E Warr, BJ Stevenson, PM Pignatelli, JC Morgan, A Steven, ...
PLoS Genet 4 (11), e1000286, 2008
Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth
JP David, HM Ismail, A Chandor-Proust, MJI Paine
Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013
A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding
S Modi, MJ Paine, MJ Sutcliffe, LY Lian, WU Primrose, CR Wolf, ...
Biochemistry 35 (14), 4540-4550, 1996
Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
SN Mitchell, BJ Stevenson, P Müller, CS Wilding, A Egyir-Yawson, ...
Proceedings of the National Academy of Sciences 109 (16), 6147-6152, 2012
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: sequential metabolism of deltamethrin revealed
BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ...
Insect biochemistry and molecular biology 41 (7), 492-502, 2011
CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae
CV Edi, L Djogbenou, AM Jenkins, K Regna, MAT Muskavitch, ...
PLoS Genet 10 (3), e1004236, 2014
Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance
I Karunker, E Morou, D Nikou, R Nauen, R Sertchook, BJ Stevenson, ...
Insect biochemistry and molecular biology 39 (10), 697-706, 2009
Processing of pro‐tumor necrosis factor‐α by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite
AM Moura‐da‐Silva, GD Laing, MJI Paine, JMTJ Dennison, V Politi, ...
European journal of immunology 26 (9), 2000-2005, 1996
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus
JM Riveron, H Irving, M Ndula, KG Barnes, SS Ibrahim, MJI Paine, ...
Proceedings of the National Academy of Sciences 110 (1), 252-257, 2013
Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents
AP Garner, MJI Paine, I Rodriguez-Crespo, EC Chinje, PO De Montellano, ...
Cancer Research 59 (8), 1929-1934, 1999
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6
MJI Paine, LA McLaughlin, JU Flanagan, CA Kemp, MJ Sutcliffe, ...
Journal of Biological Chemistry 278 (6), 4021-4027, 2003
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 m RNA in human foetal and adult brain by in situ hybridization
DE Gilham, W Cairns, MJI Paine, S Modi, R Poulsom, GCK Roberts, ...
Xenobiotica 27 (1), 111-125, 1997
Engineering of a functional human NADH-dependent cytochrome P450 system
O Döhr, MJI Paine, T Friedberg, GCK Roberts, CR Wolf
Proceedings of the National Academy of Sciences 98 (1), 81-86, 2001
Cloning and characterization of a novel human dual flavin reductase
MJI Paine, AP Garner, D Powell, J Sibbald, M Sales, N Pratt, T Smith, ...
Journal of Biological Chemistry 275 (2), 1471-1478, 2000
Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance
BJ Stevenson, P Pignatelli, D Nikou, MJI Paine
PLoS Negl Trop Dis 6 (3), e1595, 2012
Crystal structure of the FMN‐binding domain of human cytochrome P450 reductase at 1.93 Ċ resolution
Q Zhao, S Modi, G Smith, M Paine, PD Mcdonagh, CR Wolf, D Tew, ...
Protein science 8 (2), 298-306, 1999
Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae
M Riga, D Tsakireli, A Ilias, E Morou, A Myridakis, EG Stephanou, ...
Insect biochemistry and molecular biology 46, 43-53, 2014
cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom
S Nishida, T Fujita, N Kohno, H Atoda, T Morita, H Takeya, I Kido, ...
Biochemistry 34 (5), 1771-1778, 1995
Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility
GJ Lycett, LA McLaughlin, H Ranson, J Hemingway, FC Kafatos, ...
Insect molecular biology 15 (3), 321-327, 2006
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