|Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the …|
MJ Paine, HP Desmond, RD Theakston, JM Crampton
Journal of Biological Chemistry 267 (32), 22869-22876, 1992
|Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids|
P Müller, E Warr, BJ Stevenson, PM Pignatelli, JC Morgan, A Steven, ...
PLoS Genet 4 (11), e1000286, 2008
|Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth|
JP David, HM Ismail, A Chandor-Proust, MJI Paine
Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013
|A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding|
S Modi, MJ Paine, MJ Sutcliffe, LY Lian, WU Primrose, CR Wolf, ...
Biochemistry 35 (14), 4540-4550, 1996
|Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana|
SN Mitchell, BJ Stevenson, P Müller, CS Wilding, A Egyir-Yawson, ...
Proceedings of the National Academy of Sciences 109 (16), 6147-6152, 2012
|Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: sequential metabolism of deltamethrin revealed|
BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ...
Insect biochemistry and molecular biology 41 (7), 492-502, 2011
|CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae|
CV Edi, L Djogbenou, AM Jenkins, K Regna, MAT Muskavitch, ...
PLoS Genet 10 (3), e1004236, 2014
|Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance|
I Karunker, E Morou, D Nikou, R Nauen, R Sertchook, BJ Stevenson, ...
Insect biochemistry and molecular biology 39 (10), 697-706, 2009
|Processing of pro‐tumor necrosis factor‐α by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite|
AM Moura‐da‐Silva, GD Laing, MJI Paine, JMTJ Dennison, V Politi, ...
European journal of immunology 26 (9), 2000-2005, 1996
|Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus|
JM Riveron, H Irving, M Ndula, KG Barnes, SS Ibrahim, MJI Paine, ...
Proceedings of the National Academy of Sciences 110 (1), 252-257, 2013
|Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents|
AP Garner, MJI Paine, I Rodriguez-Crespo, EC Chinje, PO De Montellano, ...
Cancer Research 59 (8), 1929-1934, 1999
|Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6|
MJI Paine, LA McLaughlin, JU Flanagan, CA Kemp, MJ Sutcliffe, ...
Journal of Biological Chemistry 278 (6), 4021-4027, 2003
|Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 m RNA in human foetal and adult brain by in situ hybridization|
DE Gilham, W Cairns, MJI Paine, S Modi, R Poulsom, GCK Roberts, ...
Xenobiotica 27 (1), 111-125, 1997
|Engineering of a functional human NADH-dependent cytochrome P450 system|
O Döhr, MJI Paine, T Friedberg, GCK Roberts, CR Wolf
Proceedings of the National Academy of Sciences 98 (1), 81-86, 2001
|Cloning and characterization of a novel human dual flavin reductase|
MJI Paine, AP Garner, D Powell, J Sibbald, M Sales, N Pratt, T Smith, ...
Journal of Biological Chemistry 275 (2), 1471-1478, 2000
|Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance|
BJ Stevenson, P Pignatelli, D Nikou, MJI Paine
PLoS Negl Trop Dis 6 (3), e1595, 2012
|Crystal structure of the FMN‐binding domain of human cytochrome P450 reductase at 1.93 Ċ resolution|
Q Zhao, S Modi, G Smith, M Paine, PD Mcdonagh, CR Wolf, D Tew, ...
Protein science 8 (2), 298-306, 1999
|Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae|
M Riga, D Tsakireli, A Ilias, E Morou, A Myridakis, EG Stephanou, ...
Insect biochemistry and molecular biology 46, 43-53, 2014
|cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom|
S Nishida, T Fujita, N Kohno, H Atoda, T Morita, H Takeya, I Kido, ...
Biochemistry 34 (5), 1771-1778, 1995
|Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility|
GJ Lycett, LA McLaughlin, H Ranson, J Hemingway, FC Kafatos, ...
Insect molecular biology 15 (3), 321-327, 2006