| Involvement of caspases in proteolytic cleavage of Alzheimer’s amyloid-β precursor protein and amyloidogenic Aβ peptide formation FG Gervais, D Xu, GS Robertson, JP Vaillancourt, Y Zhu, JQ Huang, ... Cell 97 (3), 395-406, 1999 | 1006 | 1999 |
| Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism LG Goldfarb, RB Petersen, M Tabaton, P Brown, AC LeBlanc, P Montagna, ... Science 258 (5083), 806-808, 1992 | 868 | 1992 |
| Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene R Medori, HJ Tritschler, A LeBlanc, F Villare, V Manetto, HY Chen, R Xue, ... New England Journal of Medicine 326 (7), 444-449, 1992 | 838 | 1992 |
| Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons Y Zhang, R McLaughlin, C Goodyer, A LeBlanc The Journal of cell biology 156 (3), 519-529, 2002 | 552 | 2002 |
| Prion protein protects human neurons against Bax-mediated apoptosis Y Bounhar, Y Zhang, CG Goodyer, A LeBlanc Journal of Biological Chemistry 276 (42), 39145-39149, 2001 | 495 | 2001 |
| Amyloid β peptide of Alzheimer’s disease downregulates Bcl-2 and upregulates Bax expression in human neurons E Paradis, H Douillard, M Koutroumanis, C Goodyer, A LeBlanc Journal of Neuroscience 16 (23), 7533-7539, 1996 | 435 | 1996 |
| Testosterone‐mediated neuroprotection through the androgen receptor in human primary neurons J Hammond, Q Le, C Goodyer, M Gelfand, M Trifiro, A LeBlanc Journal of neurochemistry 77 (5), 1319-1326, 2001 | 398 | 2001 |
| Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease A LeBlanc, H Liu, C Goodyer, C Bergeron, J Hammond Journal of Biological Chemistry 274 (33), 23426-23436, 1999 | 370 | 1999 |
| Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease H Guo, S Albrecht, M Bourdeau, T Petzke, C Bergeron, AC LeBlanc The American journal of pathology 165 (2), 523-531, 2004 | 349 | 2004 |
| Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation V Kaushal, R Dye, P Pakavathkumar, B Foveau, J Flores, B Hyman, ... Cell Death & Differentiation 22 (10), 1676-1686, 2015 | 276 | 2015 |
| Fatal familial insomnia: a second kindred with mutation of prion protein gene at codon 178 R Medori, P Montagna, HJ Tritschler, A LeBlanc, P Cortelli, P Tinuper, ... Neurology 42 (3), 669-669, 1992 | 262 | 1992 |
| Neuroprotective functions of prion protein X Roucou, M Gains, AC LeBlanc Journal of neuroscience research 75 (2), 153-161, 2004 | 251 | 2004 |
| Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons X Roucou, Q Guo, Y Zhang, CG Goodyer, AC LeBlanc Journal of Biological Chemistry 278 (42), 40877-40881, 2003 | 237 | 2003 |
| Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model J Flores, A Noël, B Foveau, J Lynham, C Lecrux, AC LeBlanc Nature communications 9 (1), 3916, 2018 | 225 | 2018 |
| Cellular prion protein neuroprotective function: implications in prion diseases X Roucou, AC LeBlanc Journal of molecular medicine 83, 3-11, 2005 | 207 | 2005 |
| Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells X Roucou, PN Giannopoulos, Y Zhang, J Jodoin, CG Goodyer, A LeBlanc Cell Death & Differentiation 12 (7), 783-795, 2005 | 206 | 2005 |
| Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3,-6,-7, and-8 Y Zhang, C Goodyer, A LeBlanc Journal of Neuroscience 20 (22), 8384-8389, 2000 | 202 | 2000 |
| Activation of caspase-6 in aging and mild cognitive impairment S Albrecht, M Bourdeau, D Bennett, EJ Mufson, M Bhattacharjee, ... The American journal of pathology 170 (4), 1200-1209, 2007 | 198 | 2007 |
| Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis A LeBlanc Journal of Neuroscience 15 (12), 7837-7846, 1995 | 192 | 1995 |
| Estrogen and androgen protection of human neurons against intracellular amyloid β1-42 toxicity through heat shock protein 70 Y Zhang, N Champagne, LK Beitel, CG Goodyer, M Trifiro, A LeBlanc Journal of Neuroscience 24 (23), 5315-5321, 2004 | 188 | 2004 |
