| Astrocytes from familial and sporadic ALS patients are toxic to motor neurons AM Haidet-Phillips, ME Hester, CJ Miranda, K Meyer, L Braun, A Frakes, ... Nature biotechnology 29 (9), 824-828, 2011 | 898 | 2011 |
| Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis AE Frakes, L Ferraiuolo, AM Haidet-Phillips, L Schmelzer, L Braun, ... Neuron 81 (5), 1009-1023, 2014 | 651 | 2014 |
| The UPRER: sensor and coordinator of organismal homeostasis AE Frakes, A Dillin Molecular cell 66 (6), 761-771, 2017 | 272 | 2017 |
| Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism L Ferraiuolo, K Meyer, TW Sherwood, J Vick, S Likhite, A Frakes, ... Proceedings of the National Academy of Sciences 113 (42), E6496-E6505, 2016 | 194 | 2016 |
| Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis SW Song, CJ Miranda, L Braun, K Meyer, AE Frakes, L Ferraiuolo, ... Nature medicine 22 (4), 397-403, 2016 | 140 | 2016 |
| Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans AE Frakes, MG Metcalf, SU Tronnes, R Bar-Ziv, J Durieux, HK Gildea, ... Science 367 (6476), 436-440, 2020 | 109 | 2020 |
| Additive amelioration of ALS by co‐targeting independent pathogenic mechanisms AE Frakes, L Braun, L Ferraiuolo, DC Guttridge, BK Kaspar Annals of clinical and translational neurology 4 (2), 76-86, 2017 | 46 | 2017 |
| An NF-κB-EphrinA5-dependent communication between NG2+ interstitial cells and myoblasts promotes muscle growth in neonates JM Gu, DJ Wang, JM Peterson, J Shintaku, S Liyanarachchi, V Coppola, ... Developmental cell 36 (2), 215-224, 2016 | 41 | 2016 |
| rAAV gene therapy in a Canavan's disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system SS Ahmed, SA Schattgen, AE Frakes, EM Sikoglu, Q Su, J Li, ... Molecular Therapy 24 (6), 1030-1041, 2016 | 40 | 2016 |
| Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone JA Fidler, CM Treleaven, A Frakes, TJ Tamsett, M McCrate, SH Cheng, ... The FASEB Journal 25 (12), 4369, 2011 | 39 | 2011 |
| Measurements of physiological stress responses in C. elegans R Bar-Ziv, AE Frakes, R Higuchi-Sanabria, T Bolas, PA Frankino, ... JoVE (Journal of Visualized Experiments), e61001, 2020 | 34 | 2020 |
| Compositions and methods for inhibiting NF-κB and SOD-1 to treat amyotrophic lateral sclerosis BK Kaspar, AE Frakes US Patent 9,725,719, 2017 | 10 | 2017 |
| Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit HK Gildea, PA Frankino, SU Tronnes, CL Pender, J Durieux, JG Dishart, ... Science Advances 8 (49), eabq3970, 2022 | 9 | 2022 |
| MHC class I protects motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis (ALS) SW Song, CJ Miranda, L Braun, K Meyer, AE Frakes, L Ferraiuolo, ... Nature medicine 22 (4), 397, 2016 | 8 | 2016 |
| Neural stem cells as a therapeutic approach for amyotrophic lateral sclerosis L Ferraiuolo, A Frakes, BK Kaspar Molecular Therapy 21 (3), 503-505, 2013 | 7 | 2013 |
| Aging alters the metabolic flux signature of the ER‐unfolded protein response in vivo in mice CP Ward, L Peng, S Yuen, J Halstead, H Palacios, E Nyangau, ... Aging Cell 21 (3), e13558, 2022 | 6 | 2022 |
| ER unfolded protein response in liver in vivo is characterized by reduced, not increased, de novo lipogenesis and cholesterol synthesis rates with uptake of fatty acids from … CP Ward, L Peng, S Yuen, M Chang, R Karapetyan, E Nyangau, ... International Journal of Molecular Sciences 23 (3), 1073, 2022 | 4 | 2022 |
| Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue … CP Schneider, L Peng, S Yuen, M Chang, R Karapetyan, E Nyangau, ... bioRxiv, 2020.10. 29.360073, 2020 | 2 | 2020 |
| Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory circuit and serotonin HK Gildea, PA Frankino, SU Tronnes, CL Pender, HO Choi, TD Hunter, ... bioRxiv, 2022.01. 31.478522, 2022 | 1 | 2022 |
| Cell non-autonomous control of autophagy and metabolism by glial cells MG Metcalf, S Monshietehadi, A Sahay, J Durieux, AE Frakes, ... Iscience 27 (4), 2024 | | 2024 |
