High-throughput droplet digital PCR system for absolute quantitation of DNA copy number BJ Hindson, KD Ness, DA Masquelier, P Belgrader, NJ Heredia, ... Analytical chemistry 83 (22), 8604-8610, 2011 | 3107 | 2011 |
The SNPlex genotyping system: a flexible and scalable platform for SNP genotyping AR Tobler, S Short, MR Andersen, TM Paner, JC Briggs, SM Lambert, ... Journal of biomolecular techniques: JBT 16 (4), 398, 2005 | 244 | 2005 |
Multiplexed target detection using DNA-binding dye chemistry in droplet digital PCR GP McDermott, D Do, CM Litterst, D Maar, CM Hindson, ER Steenblock, ... Analytical chemistry 85 (23), 11619-11627, 2013 | 217 | 2013 |
Droplet Digital™ PCR quantitation of HER2 expression in FFPE breast cancer samples NJ Heredia, P Belgrader, S Wang, R Koehler, J Regan, AM Cosman, ... Methods 59 (1), S20-S23, 2013 | 131 | 2013 |
Universal-tagged oligonucleotide primers and methods of use KQ Lao, C Chen, RT Koehler, C Scafe, G Schroth US Patent 7,176,002, 2007 | 113 | 2007 |
Droplet Digital PCR Measurement of HER2 Copy Number Alteration in Formalin-Fixed Paraffin-Embedded Breast Carcinoma Tissue P Belgrader, SC Tanner, JF Regan, R Koehler, BJ Hindson, AS Brown Clinical chemistry 59 (6), 991-994, 2013 | 99 | 2013 |
The hidden component of size in two-dimensional fragment descriptors: side effects on sampling in bioactive libraries SL Dixon, RT Koehler Journal of medicinal chemistry 42 (15), 2887-2900, 1999 | 98 | 1999 |
A rapid molecular approach for chromosomal phasing JF Regan, N Kamitaki, T Legler, S Cooper, N Klitgord, G Karlin-Neumann, ... PloS one 10 (3), e0118270, 2015 | 94 | 2015 |
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern M Francisco, H Isaac, A Collins, CR Scafe, BV Halldórsson, X Su, ... Genome research 15 (4), 454-462, 2005 | 93* | 2005 |
System for generating droplets with pressure monitoring AL Hiddessen, KD Ness, BJ Hindson, DA Masquelier, ER Chia US Patent 9,764,322, 2017 | 92 | 2017 |
The uniqueome: a mappability resource for short-tag sequencing R Koehler, H Issac, N Cloonan, SM Grimmond Bioinformatics 27 (2), 272-274, 2011 | 83 | 2011 |
Methods for placing, accepting, and filling orders for products and services R Koehler, K Livak, J Stevens, F De La Vega, M Rhodes, L Bellon, ... US Patent App. 10/334,793, 2004 | 70 | 2004 |
Library characterization by digital assay S Saxonov, SS Tzonev, MY Lucero, RT Koehler, BJ Hindson US Patent 8,663,920, 2014 | 53 | 2014 |
Thermodynamic properties of DNA sequences: characteristic values for the human genome RT Koehler, N Peyret Bioinformatics 21 (16), 3333-3339, 2005 | 46 | 2005 |
System for detection of spaced droplets AJ Makarewicz, AL Hiddessen US Patent 9,492,797, 2016 | 43 | 2016 |
Comments on the design of chemical libraries for screening HO Villar, RT Koehler Molecular diversity 5, 13-24, 2000 | 39 | 2000 |
Ligand‐based protein alignment and isozyme specificity of glutathione S‐transferase inhibitors RT Koehler, HO Villar, KE Bauer, DL Higgins Proteins: Structure, Function, and Bioinformatics 28 (2), 202-216, 1997 | 36 | 1997 |
LASSOO: A generalized directed diversity approach to the design and enrichment of chemical libraries RT Koehler, SL Dixon, HO Villar Journal of medicinal chemistry 42 (22), 4695-4704, 1999 | 33 | 1999 |
Effects of DNA secondary structure on oligonucleotide probe binding efficiency RT Koehler, N Peyret Computational Biology and Chemistry 29 (6), 393-397, 2005 | 28 | 2005 |
A robust targeted sequencing approach for low input and variable quality DNA from clinical samples AP So, A Vilborg, Y Bouhlal, RT Koehler, SM Grimes, Y Pouliot, ... NPJ Genomic Medicine 3 (1), 2, 2018 | 27 | 2018 |