Sebastian G.B. Furness
Sebastian G.B. Furness
School of Biomedical Sceinces, University of Queensland
Verified email at - Homepage
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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ...
Nature 546 (7656), 118-123, 2017
Structure of the adenosine-bound human adenosine A 1 receptor–G i complex
CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ...
Nature 558 (7711), 559-563, 2018
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ...
Nature 555 (7694), 121-125, 2018
Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis
SGB Furness, K McNagny
Immunologic research 34, 13-32, 2006
Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors
M Morfis, N Tilakaratne, SGB Furness, G Christopoulos, TD Werry, ...
Endocrinology 149 (11), 5423-5431, 2008
The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism
D Wootten, CA Reynolds, KJ Smith, JC Mobarec, C Koole, EE Savage, ...
Cell 165 (7), 1632-1643, 2016
Activation of the GLP-1 receptor by a non-peptidic agonist
P Zhao, YL Liang, MJ Belousoff, G Deganutti, MM Fletcher, FS Willard, ...
Nature 577 (7790), 432-436, 2020
Ligand-dependent modulation of G protein conformation alters drug efficacy
SGB Furness, YL Liang, CJ Nowell, ML Halls, PJ Wookey, E Dal Maso, ...
Cell 167 (3), 739-749. e11, 2016
Differential GLP-1R binding and activation by peptide and non-peptide agonists
X Zhang, MJ Belousoff, P Zhao, AJ Kooistra, TT Truong, SY Ang, ...
Molecular Cell 80 (3), 485-500. e7, 2020
The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors
SGB Furness, MJ Lees, ML Whitelaw
FEBS letters 581 (19), 3616-3625, 2007
Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination
YL Liang, P Zhao, C Draper-Joyce, JA Baltos, A Glukhova, TT Truong, ...
ACS Pharmacology & Translational Science 1 (1), 12-20, 2018
Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP‐1R activation
K Pabreja, MA Mohd, C Koole, D Wootten, SGB Furness
British journal of pharmacology 171 (5), 1114-1128, 2014
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function
C Koole, K Pabreja, EE Savage, D Wootten, SGB Furness, LJ Miller, ...
Biochemical Society Transactions 41 (1), 172-179, 2013
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
AE Cook, SN Mistry, KJ Gregory, SGB Furness, PM Sexton, PJ Scammells, ...
British journal of pharmacology 172 (1), 185-200, 2015
A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structures
D Wootten, CA Reynolds, C Koole, KJ Smith, JC Mobarec, J Simms, ...
Molecular pharmacology 89 (3), 335-347, 2016
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
KG Harikumar, D Wootten, DI Pinon, C Koole, AM Ball, SGB Furness, ...
Proceedings of the National Academy of Sciences 109 (45), 18607-18612, 2012
The pleiotropy of dioxin toxicity—Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles
SGB Furness, F Whelan
Pharmacology & therapeutics 124 (3), 336-353, 2009
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias
KV Andreassen, ST Hjuler, SG Furness, PM Sexton, A Christopoulos, ...
PloS one 9 (3), e92042, 2014
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity …
YL Liang, MJ Belousoff, MM Fletcher, X Zhang, M Khoshouei, G Deganutti, ...
ACS Pharmacology & Translational Science, 2020
Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin
FS Willard, D Wootten, AD Showalter, EE Savage, J Ficorilli, TB Farb, ...
Molecular pharmacology 82 (6), 1066-1073, 2012
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