Neil O'Brien-Simpson
Neil O'Brien-Simpson
A/Prof of Antimicrobial and vaccine materials, The University of Melbourne
Verified email at
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Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers
SJ Lam, NM O'Brien-Simpson, N Pantarat, A Sulistio, EHH Wong, ...
Nature microbiology 1 (11), 1-11, 2016
Kappacin, a novel antibacterial peptide from bovine milk
M Malkoski, SG Dashper, NM O'Brien-Simpson, GH Talbo, M Macris, ...
Antimicrobial agents and chemotherapy 45 (8), 2309-2315, 2001
Antibiofouling polymer interfaces: poly (ethylene glycol) and other promising candidates
S Lowe, NM O'Brien-Simpson, LA Connal
Polymer Chemistry 6 (2), 198-212, 2015
Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines
Y Yan, KT Gause, MMJ Kamphuis, CS Ang, NM O’Brien-Simpson, ...
ACS nano 7 (12), 10960-10970, 2013
Porphyromonas gingivalis gingipains: the molecular teeth of a microbial vampire
NM O'Brien-Simpson, PD Veith, SG Dashper, EC Reynolds
Current Protein and Peptide Science 4 (6), 409-426, 2003
Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model
NM O'Brien-Simpson, RA Paolini, B Hoffmann, N Slakeski, SG Dashper, ...
Infection and immunity 69 (12), 7527-7534, 2001
An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss
NM O’Brien-Simpson, RD Pathirana, RA Paolini, YY Chen, PD Veith, ...
The Journal of Immunology 175 (6), 3980-3989, 2005
Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence …
PD Veith, YY Chen, DG Gorasia, D Chen, MD Glew, NM O’Brien-Simpson, ...
Journal of proteome research 13 (5), 2420-2432, 2014
Oral health risk factors for bisphosphonate-associated jaw osteonecrosis
C Tsao, I Darby, PR Ebeling, K Walsh, N O'Brien-Simpson, E Reynolds, ...
Journal of Oral and Maxillofacial Surgery 71 (8), 1360-1366, 2013
Antigens of bacteria associated with periodontitis
NM O'Brien‐Simpson, PD Veith, SG Dashper, EC Reynolds
Periodontology 2000 35 (1), 101-134, 2004
Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model
PS Rajapakse, NM O'Brien-Simpson, N Slakeski, B Hoffmann, ...
Infection and immunity 70 (5), 2480-2486, 2002
Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria
W Li, J Tailhades, NM O’Brien-Simpson, F Separovic, L Otvos, ...
Amino acids 46 (10), 2287-2294, 2014
Host immune responses to Porphyromonas gingivalis antigens.
RD Pathirana, NM O'Brien-Simpson, EC Reynolds
Periodontology 2000 52, 218-237, 2010
Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model
RD Pathirana, NM O'Brien-Simpson, GC Brammar, N Slakeski, ...
Infection and immunity 75 (3), 1436-1442, 2007
Acute phase protein and cytokine levels in serum and saliva: a comparison of detectable levels and correlations in a depressed and healthy adolescent sample
ML Byrne, NM O’Brien-Simpson, EC Reynolds, KA Walsh, K Laughton, ...
Brain, Behavior, and Immunity 34, 164-175, 2013
The outer membrane protein LptO is essential for the O‐deacylation of LPS and the co‐ordinated secretion and attachment of A‐LPS and CTD proteins in Porphyromonas gingivalis
YY Chen, B Peng, Q Yang, MD Glew, PD Veith, KJ Cross, KN Goldie, ...
Molecular microbiology 79 (5), 1380-1401, 2011
Divalent metal cations increase the activity of the antimicrobial peptide kappacin
SG Dashper, NM O'Brien-Simpson, KJ Cross, RA Paolini, B Hoffmann, ...
Antimicrobial agents and Chemotherapy 49 (6), 2322-2328, 2005
Macrophage depletion abates Porphyromonas gingivalis–induced alveolar bone resorption in mice
RS Lam, NM O’Brien-Simpson, JC Lenzo, JA Holden, GC Brammar, ...
The Journal of Immunology 193 (5), 2349-2362, 2014
Porphyromonas gingivalis RgpA-Kgp proteinase-adhesin complexes penetrate gingival tissue and induce proinflammatory cytokines or apoptosis in a concentration-dependent manner
NM O'Brien-Simpson, RD Pathirana, GD Walker, EC Reynolds
Infection and immunity 77 (3), 1246-1261, 2009
Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model
RKH Orth, NM O’Brien‐Simpson, SG Dashper, EC Reynolds
Molecular oral microbiology 26 (4), 229-240, 2011
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