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Adam Langenbucher
Adam Langenbucher
Verified email at mit.edu
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Year
Stromal microenvironment shapes the intratumoral architecture of pancreatic cancer
M Ligorio, S Sil, J Malagon-Lopez, LT Nieman, S Misale, M Di Pilato, ...
Cell 178 (1), 160-175. e27, 2019
4412019
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer
S Yoda, JJ Lin, MS Lawrence, BJ Burke, L Friboulet, A Langenbucher, ...
Cancer discovery 8 (6), 714-729, 2018
2692018
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features
R Buisson, A Langenbucher, D Bowen, EE Kwan, CH Benes, L Zou, ...
Science 364 (6447), eaaw2872, 2019
2452019
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
L Dardaei, HQ Wang, M Singh, P Fordjour, KX Shaw, S Yoda, G Kerr, ...
Nature medicine 24 (4), 512-517, 2018
1852018
MET alterations are a recurring and actionable resistance mechanism in ALK-positive lung cancer
I Dagogo-Jack, S Yoda, JK Lennerz, A Langenbucher, JJ Lin, MM Rooney, ...
Clinical Cancer Research 26 (11), 2535-2545, 2020
1462020
Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
P Jalili, D Bowen, A Langenbucher, S Park, K Aguirre, RB Corcoran, ...
Nature communications 11 (1), 2971, 2020
852020
Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion–Positive Lung Cancer
JJ Lin, NJ Choudhury, S Yoda, VW Zhu, TW Johnson, R Sakhtemani, ...
Clinical Cancer Research 27 (10), 2899-2909, 2021
782021
An extended APOBEC3A mutation signature in cancer
A Langenbucher, D Bowen, R Sakhtemani, E Bournique, JF Wise, L Zou, ...
Nature communications 12 (1), 1602, 2021
782021
Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition
JJ Lin, A Langenbucher, P Gupta, S Yoda, IJ Fetter, M Rooney, A Do, ...
NPJ precision oncology 4 (1), 21, 2020
442020
Sequential ALK inhibitors can select for lorlatinib-resistant compound ALK mutations in ALK-positive lung cancer. Cancer Discov. 2018; 8 (6): 714–729. doi: 10.1158/2159-8290
S Yoda, JJ Lin, MS Lawrence, BJ Burke, L Friboulet, A Langenbucher, ...
ALKF1174L ALKF1174L ALKL1196Q ALKC1156Y ALKG1269A ALKR1264K ALKF1174L …, 0
43
Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
M Karaayvaz-Yildirim, RE Silberman, A Langenbucher, SV Saladi, ...
Science Advances 6 (5), eaay2611, 2020
322020
Therapy-induced APOBEC3A drives evolution of persistent cancer cells
H Isozaki, R Sakhtemani, A Abbasi, N Nikpour, M Stanzione, S Oh, ...
Nature 620 (7973), 393-401, 2023
282023
A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells
S Lee, D Micalizzi, SS Truesdell, SIA Bukhari, M Boukhali, ...
Genome biology 21, 1-23, 2020
262020
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
H Guo, G Golczer, BS Wittner, A Langenbucher, M Zachariah, TD Dubash, ...
Molecular cell 81 (19), 4041-4058. e15, 2021
252021
Extracellular matrix proteins regulate NK cell function in peripheral tissues
MD Bunting, M Vyas, M Requesens, A Langenbucher, EB Schiferle, ...
Science advances 8 (11), eabk3327, 2022
222022
APOBEC mutagenesis is concordant between tumor and viral genomes in HPV-positive head and neck squamous cell carcinoma
DL Faden, KAL Kuhs, M Lin, A Langenbucher, M Pinheiro, M Yeager, ...
Viruses 13 (8), 1666, 2021
222021
YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4
N Chen, G Golczer, S Ghose, B Lin, A Langenbucher, J Webb, H Bhanot, ...
Cell reports 39 (11), 2022
202022
APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer
H Isozaki, A Abbasi, N Nikpour, A Langenbucher, W Su, M Stanzione, ...
BioRxiv, 2021.01. 20.426852, 2021
182021
RASAL2 confers collateral MEK/EGFR dependency in chemoresistant triple-negative breast cancer
SB Koh, K Ross, SJ Isakoff, N Melkonjan, L He, KJ Matissek, A Schultz, ...
Clinical Cancer Research 27 (17), 4883-4897, 2021
112021
HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures
DL Faden, A Langenbucher, K Kuhs, JS Lewis, L Mirabello, M Yeager, ...
Carcinogenesis 42 (1), 14-20, 2021
62021
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