KM Hannan
KM Hannan
John Curtin School of Medical Research
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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar …
KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ...
Molecular and cellular biology 23 (23), 8862-8877, 2003
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson
Growth factors 25 (4), 209-226, 2007
Targeting the nucleolus for cancer intervention
JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ...
Oncogene 31 (15), 1949-1962, 2012
The nucleolus: an emerging target for cancer therapy
N Hein, KM Hannan, AJ George, E Sanij, RD Hannan
Trends in molecular medicine 19 (11), 643-654, 2013
UBF levels determine the number of active ribosomal RNA genes in mammals
E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ...
The Journal of cell biology 183 (7), 1259-1274, 2008
MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation
G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, ...
The EMBO journal 23 (16), 3325-3335, 2004
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1
KM Hannan, RD Hannan, SD Smith, LS Jefferson, M Lun, LI Rothblum
Oncogene 19 (43), 4988-4999, 2000
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer
JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ...
Science signaling 4 (188), ra56-ra56, 2011
Transcription by RNA polymerase I
KM Hannan, RD Hannan, LI Rothblum
Frontiers in Bioscience-Landmark 3 (4), 376-398, 1998
Direct Identification of Tyrosine 474 as a Regulatory Phosphorylation Site for the Akt Protein Kinase* 210
NM Conus, KM Hannan, BE Cristiano, BA Hemmings, RB Pearson
Journal of Biological Chemistry 277 (41), 38021-38028, 2002
Dysregulation of RNA polymerase I transcription during disease
KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson
Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829 (3-4 …, 2013
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy
SJ Woods, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (7), 821-829, 2015
A specific role for AKT3 in the genesis of ovarian cancer through modulation of G2-M phase transition
BE Cristiano, JC Chan, KM Hannan, NA Lundie, NJ Marmy-Conus, ...
Cancer Research 66 (24), 11718-11725, 2006
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
M Wall, G Poortinga, KM Hannan, RB Pearson, RD Hannan, GA McArthur
Blood, The Journal of the American Society of Hematology 112 (6), 2305-2317, 2008
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest
KM Hannan, BK Kennedy, AH Cavanaugh, RD Hannan, ...
Oncogene 19 (31), 3487-3497, 2000
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven LymphomaTargeting the Ribosome to Treat MYC-Driven Lymphoma
JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ...
Cancer discovery 6 (1), 59-70, 2016
Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors
KE Sheppard, C Cullinane, KM Hannan, M Wall, J Chan, F Barber, J Foo, ...
European journal of cancer 49 (18), 3936-3944, 2013
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ...
Oncotarget 7 (31), 49800, 2016
Regulation of rDNA transcription in response to growth factors, nutrients and energy
EP Kusnadi, KM Hannan, RJ Hicks, RD Hannan, RB Pearson, J Kang
Gene 556 (1), 27-34, 2015
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