Zaklina Kovacevic
Zaklina Kovacevic
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Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors
Y Yu, DS Kalinowski, Z Kovacevic, AR Siafakas, PJ Jansson, C Stefani, ...
Journal of medicinal chemistry 52 (17), 5271-5294, 2009
Tuning cell cycle regulation with an iron key
Y Yu, Z Kovacevic, DR Richardson
Cell cycle 6 (16), 1982-1994, 2007
The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1)
Z Chen, D Zhang, F Yue, M Zheng, Z Kovacevic, DR Richardson
Journal of Biological Chemistry 287 (21), 17016-17028, 2012
The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer
Z Kovacevic, DR Richardson
Carcinogenesis 27 (12), 2355-2366, 2006
Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
J Paluncic, Z Kovacevic, PJ Jansson, D Kalinowski, AM Merlot, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863 (4), 770-784, 2016
Iron chelators for the treatment of cancer
Y Yu, E Gutierrez, Z Kovacevic, F Saletta, P Obeidy, Y Suryo Rahmanto, ...
Current medicinal chemistry 19 (17), 2689-2702, 2012
Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the …
Z Kovacevic, S Chikhani, DB Lovejoy, DR Richardson
Molecular pharmacology 80 (4), 598-609, 2011
The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways
Z Kovacevic, S Chikhani, GYL Lui, S Sivagurunathan, DR Richardson
Antioxidants & redox signaling 18 (8), 874-887, 2013
Targeting cancer by binding iron: Dissecting cellular signaling pathways
GYL Lui, Z Kovacevic, V Richardson, AM Merlot, DS Kalinowski, ...
Oncotarget 6 (22), 18748, 2015
Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy
BA Fang, Ž Kovačević, KC Park, DS Kalinowski, PJ Jansson, DJR Lane, ...
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1845 (1), 1-19, 2014
The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones
PJ Jansson, DS Kalinowski, DJR Lane, Z Kovacevic, NA Seebacher, ...
Pharmacological research 100, 255-260, 2015
Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors
J Sun, D Zhang, DH Bae, S Sahni, P Jansson, Y Zheng, Q Zhao, F Yue, ...
Carcinogenesis 34 (9), 1943-1954, 2013
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
DS Kalinowski, C Stefani, S Toyokuni, T Ganz, GJ Anderson, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863 (4), 727-748, 2016
The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action
GYL Lui, P Obeidy, SJ Ford, C Tselepis, DM Sharp, PJ Jansson, ...
Molecular pharmacology 83 (1), 179-190, 2013
Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells
KM Dixon, GYL Lui, Z Kovacevic, D Zhang, M Yao, Z Chen, Q Dong, ...
British journal of cancer 108 (2), 409-419, 2013
The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology
MA Cahill, JA Jazayeri, SM Catalano, S Toyokuni, Z Kovacevic, ...
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1866 (2), 339-349, 2016
The TGF-β, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer
SJ Assinder, Q Dong, Z Kovacevic, DR Richardson
Biochemical Journal 417 (2), 411-421, 2009
The role of NDRG1 in the pathology and potential treatment of human cancers
DH Bae, PJ Jansson, ML Huang, Z Kovacevic, D Kalinowski, CS Lee, ...
Journal of clinical pathology 66 (11), 911-917, 2013
The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4
R Jin, W Liu, S Menezes, F Yue, M Zheng, Z Kovacevic, DR Richardson
Journal of cell science 127 (14), 3116-3130, 2014
Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial–mesenchymal transition
DJR Lane, TM Mills, NH Shafie, AM Merlot, RS Moussa, DS Kalinowski, ...
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1845 (2), 166-181, 2014
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