Ashley Bush
Ashley Bush
Massachusetts General Hospital, Florey Institute of Neuroscience & Mental Health
Verified email at helix.mgh.harvard.edu
TitleCited byYear
Neurodegenerative diseases and oxidative stress
KJ Barnham, CL Masters, AI Bush
Nature reviews Drug discovery 3 (3), 205, 2004
25612004
Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
CA McLean, RA Cherny, FW Fraser, SJ Fuller, MJ Smith, K Vbeyreuther, ...
Annals of neurology 46 (6), 860-866, 1999
19761999
Rapid induction of Alzheimer A beta amyloid formation by zinc
AI Bush, WH Pettingell, G Multhaup, M d Paradis, JP Vonsattel, JF Gusella, ...
Science 265 (5177), 1464-1467, 1994
15721994
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones, CA McLean, ...
Neuron 30 (3), 665-676, 2001
15172001
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
RE Tanzi, K Petrukhin, I Chernov, JL Pellequer, W Wasco, B Ross, ...
Nature genetics 5 (4), 344, 1993
13971993
The neurobiology of zinc in health and disease
CJ Frederickson, JY Koh, AI Bush
Nature Reviews Neuroscience 6 (6), 449, 2005
13762005
The metallobiology of Alzheimer's disease
AI Bush
Trends in neurosciences 26 (4), 207-214, 2003
12092003
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
X Huang, CS Atwood, MA Hartshorn, G Multhaup, LE Goldstein, ...
Biochemistry 38 (24), 7609-7616, 1999
11741999
Dramatic aggregation of Alzheimer Aβ by Cu (II) is induced by conditions representing physiological acidosis
CS Atwood, RD Moir, X Huang, RC Scarpa, NME Bacarra, DM Romano, ...
Journal of Biological Chemistry 273 (21), 12817-12826, 1998
11211998
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
CW Ritchie, AI Bush, A Mackinnon, S Macfarlane, M Mastwyk, ...
Archives of neurology 60 (12), 1685-1691, 2003
9882003
Cu (II) potentiation of Alzheimer Aβ neurotoxicity correlation with cell-free hydrogen peroxide production and metal reduction
X Huang, MP Cuajungco, CS Atwood, MA Hartshorn, JDA Tyndall, ...
Journal of Biological Chemistry 274 (52), 37111-37116, 1999
8801999
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
F Ng, M Berk, O Dean, AI Bush
International Journal of Neuropsychopharmacology 11 (6), 851-876, 2008
8302008
Metals and neuroscience
AI Bush
Current opinion in chemical biology 4 (2), 184-191, 2000
7952000
Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
CC Curtain, F Ali, I Volitakis, RA Cherny, RS Norton, K Beyreuther, ...
Journal of Biological Chemistry 276 (23), 20466-20473, 2001
7002001
Characterization of Copper Interactions with Alzheimer Amyloid β Peptides: Identification of an Attomolar‐Affinity Copper Binding Site on Amyloid β1‐42
CS Atwood, RC Scarpa, X Huang, RD Moir, WD Jones, DP Fairlie, ...
Journal of neurochemistry 75 (3), 1219-1233, 2000
6862000
Metalloenzyme-like activity of Alzheimer's disease β-amyloid Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
C Opazo, X Huang, RA Cherny, RD Moir, AE Roher, AR White, R Cappai, ...
Journal of Biological Chemistry 277 (43), 40302-40308, 2002
6632002
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
L Lannfelt, K Blennow, H Zetterberg, S Batsman, D Ames, J Harrison, ...
The Lancet Neurology 7 (9), 779-786, 2008
6092008
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ
PA Adlard, RA Cherny, DI Finkelstein, E Gautier, E Robb, M Cortes, ...
Neuron 59 (1), 43-55, 2008
6032008
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease
D Kaur, F Yantiri, S Rajagopalan, J Kumar, JQ Mo, R Boonplueang, ...
Neuron 37 (6), 899-909, 2003
6022003
Metals in Alzheimer's and Parkinson's diseases
KJ Barnham, AI Bush
Current opinion in chemical biology 12 (2), 222-228, 2008
5832008
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