|Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes|
D Beck, JAI Thoms, D Perera, J Schütte, A Unnikrishnan, K Knezevic, ...
Blood, The Journal of the American Society of Hematology 122 (14), e12-e22, 2013
|Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells|
D Jing, VA Bhadri, D Beck, JAI Thoms, NA Yakob, JWH Wong, K Knezevic, ...
Blood, The Journal of the American Society of Hematology 125 (2), 273-283, 2015
|ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer|
JAI Thoms, Y Birger, S Foster, K Knezevic, Y Kirschenbaum, ...
Blood, The Journal of the American Society of Hematology 117 (26), 7079-7089, 2011
|Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex|
JM Percival, JAI Hughes, DL Brown, G Schevzov, K Heimann, B Vrhovski, ...
Molecular biology of the cell 15 (1), 268-280, 2004
|Integrative genomics identifies the molecular basis of resistance to azacitidine therapy in myelodysplastic syndromes|
A Unnikrishnan, E Papaemmanuil, D Beck, NP Deshpande, A Verma, ...
Cell reports 20 (3), 572-585, 2017
|Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia|
E Diffner, D Beck, E Gudgin, JAI Thoms, K Knezevic, C Pridans, S Foster, ...
Blood, The Journal of the American Society of Hematology 121 (12), 2289-2300, 2013
|Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma|
ML Yager, JAI Hughes, FJ Lovicu, PW Gunning, RP Weinberger, ...
British journal of cancer 89 (5), 860-863, 2003
|High‐molecular‐weight tropomyosins localize to the contractile rings of dividing CNS cells but are absent from malignant pediatric and adult CNS tumors|
JAI Hughes, CM Cooke‐Yarborough, NC Chadwick, G Schevzov, ...
Glia 42 (1), 25-35, 2003
|Functional mutations form at CTCF-cohesin binding sites in melanoma due to uneven nucleotide excision repair across the motif|
RC Poulos, JAI Thoms, YF Guan, A Unnikrishnan, JE Pimanda, ...
Cell reports 17 (11), 2865-2872, 2016
|A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients|
SH Oram, JAI Thoms, C Pridans, ME Janes, SJ Kinston, S Anand, ...
Oncogene 29 (43), 5796-5808, 2010
|Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels|
EM McGowan, RP Weinberger, JD Graham, HD Hill, JAI Hughes, ...
Journal of molecular endocrinology 31 (2), 241-254, 2003
|Systematic screening of promoter regions pinpoints functional cis-regulatory mutations in a cutaneous melanoma genome|
RC Poulos, JAI Thoms, A Shah, D Beck, JE Pimanda, JWH Wong
Molecular Cancer Research 13 (8), 1218-1226, 2015
|A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients|
D Beck, JAI Thoms, C Palu, T Herold, A Shah, J Olivier, L Boelen, ...
Leukemia 32 (2), 263-272, 2018
|MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation|
Y Huang, JAI Thoms, ML Tursky, K Knezevic, D Beck, V Chandrakanthan, ...
Leukemia 30 (7), 1552-1561, 2016
|Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias|
ML Tursky, D Beck, JAI Thoms, Y Huang, A Kumari, A Unnikrishnan, ...
Leukemia 29 (4), 819-827, 2015
|OncoCis: Annotation of cis-regulatory mutations in cancer|
D Perera, D Chacon, JAI Thoms, RC Poulos, A Shilen, D Beck, ...
Genome Biology 15, 485, 2014
|A tropomyosin 1 induced defect in cytokinesis can be rescued by elevated expression of cofilin|
JAI Thoms, HM Loch, JR Bamburg, PW Gunning, RP Weinberger
Cell motility and the cytoskeleton 65 (12), 979-990, 2008
|The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1|
CL Carmichael, J Wang, T Nguyen, O Kolawole, A Benyoucef, ...
Blood 136 (8), 957-973, 2020
|Transcriptional networks in acute myeloid leukemia|
JAI Thoms, D Beck, JE Pimanda
Genes, Chromosomes and Cancer 58 (12), 859-874, 2019
|Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method|
K Liu, D Beck, JAI Thoms, L Liu, W Zhao, JE Pimanda, X Zhou
Bioinformatics 33 (17), 2622-2630, 2017