| 6-Substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer BJ Buckley, A Aboelela, E Minaei, LX Jiang, Z Xu, U Ali, K Fildes, ... Journal of medicinal chemistry 61 (18), 8299-8320, 2018 | 60 | 2018 |
| 5′-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor A Massink, J Louvel, I Adlere, C van Veen, BJH Huisman, GS Dijksteel, ... Journal of medicinal chemistry 59 (10), 4769-4777, 2016 | 36 | 2016 |
| The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets. BJ Buckley, U Ali, MJ Kelso, M Ranson Current drug targets, 2018 | 34 | 2018 |
| An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis K Hards, CY Cheung, N Waller, C Adolph, L Keighley, ZS Tee, LK Harold, ... Communications Biology 5 (1), 166, 2022 | 23 | 2022 |
| 6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease BJ Buckley, H Majed, A Aboelela, E Minaei, L Jiang, K Fildes, CY Cheung, ... Bioorganic & medicinal chemistry letters 29 (24), 126753, 2019 | 21 | 2019 |
| The urokinase plasminogen activation system in pancreatic cancer: prospective diagnostic and therapeutic targets AA Kumar, BJ Buckley, M Ranson Biomolecules 12 (2), 152, 2022 | 19 | 2022 |
| Screening of 5-and 6-substituted amiloride libraries identifies dual-uPA/NHE1 active and single target-selective inhibitors BJ Buckley, A Kumar, A Aboelela, RS Bujaroski, X Li, H Majed, L Fliegel, ... International Journal of Molecular Sciences 22 (6), 2999, 2021 | 16 | 2021 |
| Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU) SMZ Hosen, MN Uddin, Z Xu, BJ Buckley, C Perera, TCY Pang, ... Frontiers in immunology 13, 1060957, 2022 | 15 | 2022 |
| Systematic evaluation of structure–property relationships and pharmacokinetics in 6-(hetero) aryl-substituted matched pair analogs of amiloride and 5-(N, N-hexamethylene) amiloride BJ Buckley, A Aboelela, H Majed, RS Bujaroski, KL White, AK Powell, ... Bioorganic & Medicinal Chemistry 37, 116116, 2021 | 10 | 2021 |
| Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion X Li, B Buckley, K Stoletov, Y Jing, M Ranson, JD Lewis, M Kelso, ... International Journal of Molecular Sciences 22 (24), 13263, 2021 | 8 | 2021 |
| Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity NS El Salamouni, BJ Buckley, M Ranson, MJ Kelso, H Yu Biophysical Reviews, 1-25, 2022 | 7 | 2022 |
| Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types MI Islam, JH Bae, T Ishida, P Ridone, J Lin, MJ Kelso, Y Sowa, BJ Buckley, ... Journal of Bacteriology 203 (22), 10.1128/jb. 00367-21, 2021 | 7 | 2021 |
| 6-furopyridine hexamethylene amiloride is a non-selective P2X7 receptor antagonist P Cuthbertson, A Elhage, D Al-Rifai, RA Sophocleous, RJ Turner, ... Biomolecules 12 (9), 1309, 2022 | 5 | 2022 |
| Disruption of water networks is the cause of human/mouse species selectivity in urokinase plasminogen activator (uPA) inhibitors derived from hexamethylene amiloride (HMA) N S El Salamouni, BJ Buckley, L Jiang, M Huang, M Ranson, MJ Kelso, ... Journal of Medicinal Chemistry 65 (3), 1933-1945, 2021 | 5 | 2021 |
| Automated Patch Clamp Screening of Amiloride and 5-N,N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel … RK Finol-Urdaneta, JR McArthur, A Aboelela, RS Bujaroski, H Majed, ... Molecular Pharmaceutics 20 (7), 3367-3379, 2023 | 1 | 2023 |
| Ion Transport and Inhibitor Binding by Human NHE1: Insights from Molecular Dynamics Simulations and Free Energy Calculations NS El Salamouni, BJ Buckley, R Lee, M Ranson, MJ Kelso, H Yu The Journal of Physical Chemistry B 128 (2), 440-450, 2024 | | 2024 |
| A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis C Adolph, CY Cheung, MB McNeil, WJ Jowsey, ZC Williams, K Hards, ... Cell Chemical Biology, 2023 | | 2023 |
| Preclinical Evaluation of Bisantrene As Single Agent and in Combination with Decitabine for Acute Myeloid Leukemia NM Verrills, HC Murray, JS Brzozowski, N Panicker, K Miller, M Messina, ... Blood 142, 5773, 2023 | | 2023 |
| PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension TV Kudryashova, S Zaitsev, L Jiang, BJ Buckley, JP McGuckin, ... bioRxiv, 2023.09. 21.558893, 2023 | | 2023 |
| Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs K Vu, BJ Buckley, RS Bujaroski, E Blumwald, MJ Kelso, A Gelli Frontiers in Cellular and Infection Microbiology 13, 1101568, 2023 | | 2023 |
