|Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway|
S Lehnardt, L Massillon, P Follett, FE Jensen, R Ratan, PA Rosenberg, ...
Proceedings of the National Academy of Sciences 100 (14), 8514-8519, 2003
|Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice|
RJ Ferrante, JK Kubilus, J Lee, H Ryu, A Beesen, B Zucker, K Smith, ...
Journal of Neuroscience 23 (28), 9418-9427, 2003
|Rapid communication: Oxidative stress induces apoptosis in embryonic cortical neurons|
RR Ratan, TH Murphy, JM Baraban
Journal of neurochemistry 62 (1), 376-379, 1994
|Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease|
G Gardian, SE Browne, DK Choi, P Klivenyi, J Gregorio, JK Kubilus, ...
Journal of Biological Chemistry 280 (1), 556-563, 2005
|Protection from oxidative stress–induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced dna binding of hypoxia-inducible factor-1 and atf …|
K Zaman, H Ryu, D Hall, K O'Donovan, KI Lin, MP Miller, JC Marquis, ...
Journal of Neuroscience 19 (22), 9821-9830, 1999
|Therapeutic effects of cystamine in a murine model of Huntington's disease|
A Dedeoglu, JK Kubilus, TM Jeitner, SA Matson, M Bogdanov, NW Kowall, ...
Journal of Neuroscience 22 (20), 8942-8950, 2002
|Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox|
J Lee, H Ryu, RJ Ferrante, SM Morris, RR Ratan
Proceedings of the National Academy of Sciences 100 (8), 4843-4848, 2003
|Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro|
D Cai, K Deng, W Mellado, J Lee, RR Ratan, MT Filbin
Neuron 35 (4), 711-719, 2002
|Hypoxia-inducible factor prolyl 4-hydroxylase inhibition a target for neuroprotection in the central nervous system|
A Siddiq, IA Ayoub, JC Chavez, L Aminova, S Shah, JC LaManna, ...
Journal of Biological Chemistry 280 (50), 41732-41743, 2005
|Molecular basis of vitamin E action tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration|
S Khanna, S Roy, H Ryu, P Bahadduri, PW Swaan, RR Ratan, CK Sen
Journal of Biological Chemistry 278 (44), 43508-43515, 2003
|Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate|
SF Sleiman, J Henry, R Al-Haddad, L El Hayek, E Abou Haidar, T Stringer, ...
Elife 5, e15092, 2016
|Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?|
MW Bourassa, I Alim, SJ Bultman, RR Ratan
Neuroscience letters 625, 56-63, 2016
|HDAC6 is a target for protection and regeneration following injury in the nervous system|
MA Rivieccio, C Brochier, DE Willis, BA Walker, MA D'Annibale, ...
Proceedings of the National Academy of Sciences 106 (46), 19599-19604, 2009
|Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis|
S Camelo, AH Iglesias, D Hwang, B Due, H Ryu, K Smith, SG Gray, ...
Journal of neuroimmunology 164 (1-2), 10-21, 2005
|Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway|
H Ryu, J Lee, BA Olofsson, A Mwidau, A Deodoglu, M Escudero, ...
Proceedings of the National Academy of Sciences 100 (7), 4281-4286, 2003
|Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione|
RR Ratan, TH Murphy, JM Baraban
Journal of Neuroscience 14 (7), 4385-4392, 1994
|Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.|
KI Lin, SH Lee, R Narayanan, JM Baraban, JM Hardwick, RR Ratan
The Journal of Cell Biology 131 (5), 1149-1161, 1995
|Neuronal (type I) nitric oxide synthase regulates nuclear factorκB activity and immunologic (type II) nitric oxide synthase expression|
H Togashi, M Sasaki, E Frohman, E Taira, RR Ratan, TM Dawson, ...
Proceedings of the National Academy of Sciences 94 (6), 2676-2680, 1997
|Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons|
H Ryu, J Lee, K Zaman, J Kubilis, RJ Ferrante, BD Ross, R Neve, ...
Journal of Neuroscience 23 (9), 3597-3606, 2003
|Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative …|
GE Gibson, A Starkov, JP Blass, RR Ratan, MF Beal
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (1), 122-134, 2010