|A randomized trial of protocol-based care for early septic shock|
New England Journal of Medicine 370 (18), 1683-1693, 2014
|Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial|
AE Jones, NI Shapiro, S Trzeciak, RC Arnold, HA Claremont, JA Kline, ...
Jama 303 (8), 739-746, 2010
|Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality|
JH Kilgannon, AE Jones, NI Shapiro, MG Angelos, B Milcarek, K Hunter, ...
Jama 303 (21), 2165-2171, 2010
|Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury|
K Kashani, A Al-Khafaji, T Ardiles, A Artigas, SM Bagshaw, M Bell, ...
Critical care 17 (1), R25, 2013
|Serum lactate as a predictor of mortality in emergency department patients with infection|
NI Shapiro, MD Howell, D Talmor, LA Nathanson, A Lisbon, RE Wolfe, ...
Annals of emergency medicine 45 (5), 524-528, 2005
|Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis|
RC Arnold, NI Shapiro, AE Jones, C Schorr, J Pope, E Casner, JE Parrillo, ...
Shock 32 (1), 35-39, 2009
|Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule|
NI Shapiro, RE Wolfe, RB Moore, E Smith, E Burdick, DW Bates
Critical care medicine 31 (3), 670-675, 2003
|National estimates of severe sepsis in United States emergency departments|
HE Wang, NI Shapiro, DC Angus, DM Yealy
Critical care medicine 35 (8), 1928-1936, 2007
|Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol|
NI Shapiro, MD Howell, D Talmor, D Lahey, L Ngo, J Buras, RE Wolfe, ...
Critical care medicine 34 (4), 1025-1032, 2006
|Occult hypoperfusion and mortality in patients with suspected infection|
MD Howell, M Donnino, P Clardy, D Talmor, NI Shapiro
Intensive care medicine 33 (11), 1892-1899, 2007
|Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis|
S Trzeciak, JV McCoy, RP Dellinger, RC Arnold, M Rizzuto, NL Abate, ...
Intensive care medicine 34 (12), 2210-2217, 2008
|Demonstration of high‐fidelity simulation team training for emergency medicine|
SD Small, RC Wuerz, R Simon, N Shapiro, A Conn, G Setnik
Academic Emergency Medicine 6 (4), 312-323, 1999
|Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol|
MA Puskarich, S Trzeciak, NI Shapiro, RC Arnold, JM Horton, JR Studnek, ...
Critical care medicine 39 (9), 2066, 2011
|Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial|
W Wang, HL Li, DX Wang, X Zhu, SL Li, GQ Yao, KS Chen, XE Gu, ...
Critical care medicine 40 (3), 731-739, 2012
|Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest|
JH Kilgannon, AE Jones, JE Parrillo, RP Dellinger, B Milcarek, K Hunter, ...
Circulation 123 (23), 2717-2722, 2011
|Multicenter study of central venous oxygen saturation (ScvO2) as a predictor of mortality in patients with sepsis|
JV Pope, AE Jones, DF Gaieski, RC Arnold, S Trzeciak, NI Shapiro, ...
Annals of emergency medicine 55 (1), 40-46. e1, 2010
|A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis|
NI Shapiro, S Trzeciak, JE Hollander, R Birkhahn, R Otero, TM Osborn, ...
Critical care medicine 37 (1), 96-104, 2009
|The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection|
N Shapiro, MD Howell, DW Bates, DC Angus, L Ngo, D Talmor
Annals of emergency medicine 48 (5), 583-590. e1, 2006
|The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis|
AE Jones, MD Brown, S Trzeciak, NI Shapiro, JS Garrett, AC Heffner, ...
Critical care medicine 36 (10), 2734, 2008
|Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients|
DW Callaway, NI Shapiro, MW Donnino, C Baker, CL Rosen
Journal of Trauma and Acute Care Surgery 66 (4), 1040-1044, 2009