| The Genome Sequence of Drosophila melanogaster MD Adams, SE Celniker, RA Holt, CA Evans, JD Gocayne, ... Science 287 (5461), 2185-2195, 2000 | 8182 | 2000 |
| A prudent path forward for genomic engineering and germline gene modification D Baltimore, P Berg, M Botchan, D Carroll, RA Charo, G Church, JE Corn, ... Science 348 (6230), 36-38, 2015 | 938 | 2015 |
| Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase SE Moyer, PW Lewis, MR Botchan Proceedings of the National Academy of Sciences 103 (27), 10236-10241, 2006 | 824 | 2006 |
| Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences M Lusky, M Botchan Nature 293 (5827), 79-81, 1981 | 726 | 1981 |
| The arrangement of simian virus 40 sequences in the DNA of transformed cells M Botchan, W Topp, J Sambrook Cell 9 (2), 269-287, 1976 | 641 | 1976 |
| Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins I Ilves, T Petojevic, JJ Pesavento, MR Botchan Molecular cell 37 (2), 247-258, 2010 | 629 | 2010 |
| Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator IJ Mohr, R Clark, S Sun, EJ Androphy, P MacPherson, MR Botchan Science 250 (4988), 1694-1699, 1990 | 564 | 1990 |
| Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes DTS Pak, M Pflumm, I Chesnokov, R Kellum, J Marr, P Romanowski, ... Cell 91 (3), 311-323, 1997 | 494 | 1997 |
| The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication R Li, MR Botchan Cell 73 (6), 1207-1221, 1993 | 428 | 1993 |
| High mutation frequency in DNA transfected into mammalian cells. MP Calos, JS Lebkowski, MR Botchan Proceedings of the National Academy of Sciences 80 (10), 3015-3019, 1983 | 428 | 1983 |
| Activation of BPV-1 replication in vitro by the transcription factor E2 L Yang, R Li, IJ Mohr, R Clark, MR Botchan Nature 353 (6345), 628-632, 1991 | 380 | 1991 |
| Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription R Li, JD Knight, SP Jackson, R Tjian, MR Botchan Cell 65 (3), 493-505, 1991 | 379 | 1991 |
| Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition MM Harrison, XY Li, T Kaplan, MR Botchan, MB Eisen PLoS genetics 7 (10), e1002266, 2011 | 364 | 2011 |
| The structural basis for MCM2–7 helicase activation by GINS and Cdc45 A Costa, I Ilves, N Tamberg, T Petojevic, E Nogales, MR Botchan, ... Nature structural & molecular biology 18 (4), 471-477, 2011 | 345 | 2011 |
| The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase. L Yang, I Mohr, E Fouts, DA Lim, M Nohaile, M Botchan Proceedings of the National Academy of Sciences 90 (11), 5086-5090, 1993 | 341 | 1993 |
| The retinoblastoma gene product regulates Sp1-mediated transcription SJ Kim, US Onwuta, YI Lee, R Li, MR Botchan, PD Robbins Molecular and cellular biology 12 (6), 2455-2463, 1992 | 326 | 1992 |
| Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex PW Lewis, EL Beall, TC Fleischer, D Georlette, AJ Link, MR Botchan Genes & development 18 (23), 2929-2940, 2004 | 301 | 2004 |
| DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC–DNA binding D Remus, EL Beall, MR Botchan The EMBO journal 23 (4), 897-907, 2004 | 295 | 2004 |
| Role for a Drosophila Myb-containing protein complex in site-specific DNA replication EL Beall, JR Manak, S Zhou, M Bell, JS Lipsick, MR Botchan Nature 420 (6917), 833-837, 2002 | 285 | 2002 |
| Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome. R Li, J Knight, G Bream, A Stenlund, M Botchan Genes & Development 3 (4), 510-526, 1989 | 264 | 1989 |
