Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development JK Archbold, JU Flanagan, HA Watkins, JJ Gingell, DL Hay Trends in pharmacological sciences 32 (10), 591-600, 2011 | 109 | 2011 |
Calcitonin and calcitonin receptor‐like receptors: common themes with family B GPCRs? J Barwell, JJ Gingell, HA Watkins, JK Archbold, DR Poyner, DL Hay British journal of pharmacology 166 (1), 51-65, 2012 | 95 | 2012 |
Activity of Pramlintide, Rat and Human Amylin but not Aβ1–42 at Human Amylin Receptors JJ Gingell, ER Burns, DL Hay Endocrinology 155 (1), 21-26, 2014 | 66 | 2014 |
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology J J Gingell, J Simms, J Barwell, DR Poyner, HA Watkins, AA Pioszak, ... Cell discovery 2 (1), 1-14, 2016 | 64 | 2016 |
New insights into the regulation of CGRP-family receptors JJ Gingell, ER Hendrikse, DL Hay Trends in pharmacological sciences 40 (1), 71-83, 2019 | 50 | 2019 |
Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding EL Moore, JJ Gingell, SA Kane, DL Hay, CA Salvatore Biochemical and biophysical research communications 394 (1), 141-145, 2010 | 49 | 2010 |
A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor JJ Gingell, T Qi, RJ Bailey, DL Hay Peptides 31 (7), 1400-1404, 2010 | 48 | 2010 |
Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties HA Watkins, M Chakravarthy, RS Abhayawardana, JJ Gingell, M Garelja, ... Journal of Biological Chemistry 291 (22), 11657-11675, 2016 | 47 | 2016 |
Distinct patterns of internalization of different calcitonin gene-related peptide receptors JJ Gingell, TA Rees, ER Hendrikse, A Siow, D Rennison, J Scotter, ... ACS Pharmacology & Translational Science 3 (2), 296-304, 2020 | 46 | 2020 |
Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins DL Hay, CS Walker, JJ Gingell, G Ladds, CA Reynolds, DR Poyner Biochemical Society Transactions 44 (2), 568-573, 2016 | 41 | 2016 |
Molecular mechanisms of class B GPCR activation: insights from adrenomedullin receptors ML Garelja, M Au, MA Brimble, JJ Gingell, ER Hendrikse, A Lovell, ... ACS pharmacology & translational science 3 (2), 246-262, 2020 | 34 | 2020 |
Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor … J Simms, R Uddin, TP Sakmar, JJ Gingell, ML Garelja, DL Hay, ... Biochemistry 57 (32), 4915-4922, 2018 | 27 | 2018 |
N-Glycosylation of asparagine 130 in the extracellular domain of the human calcitonin receptor significantly increases peptide hormone affinity SM Lee, JM Booe, JJ Gingell, V Sjoelund, DL Hay, AA Pioszak Biochemistry 56 (26), 3380-3393, 2017 | 18 | 2017 |
A potent fluorescent calcitonin gene‐related peptide analogue enables visualization of receptor internalization LR Yule, ML Garelja, ER Hendrikse, JJ Gingell, DR Poyner, PWH Harris, ... Peptide Science 111 (6), e24126, 2019 | 10 | 2019 |
Receptor activity modifying proteins have limited effects on the Class BG protein-coupled receptor calcitonin receptor-like receptor stalk ML Garelja, CA Walker, A Siow, SH Yang, PWR Harris, MA Brimble, ... Biochemistry 57 (8), 1410-1422, 2018 | 10 | 2018 |
Vasopressin-oxytocin–type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians A Kobayashi, M Hamada, M Yoshida, Y Kobayashi, N Tsutsui, ... Science Advances 8 (9), eabk0331, 2022 | 5 | 2022 |
Differential internalisation of the CGRP and AMY1 receptor TA Rees, J Gingell, A Siow, P Harris, M Brimble, D Hay, C Walker The FASEB Journal 34 (S1), 1-1, 2020 | 1 | 2020 |
Class B GPCR: Receptors and RAMPs JJ Gingell, CS Walker, DL Hay G-Protein-Coupled Receptor Dimers, 289-305, 2017 | 1 | 2017 |
Detergent free isolation of the CGRP receptor using styrene-maleic acid co-polymer JJ Gingell, M Wheatley, DR Poyner, DL Hay FEBS JOURNAL 284, 162-162, 2017 | | 2017 |
Michael Garelja1, Meenakshi Pardamwar3, James MWR McElhinney3, Alex Lathbridge3, Arran Constantine3, Paul WR Harris2, 4, Tsz-Ying Yuen2, 4, Margaret A. Brimble2, 4, James … HA Watkins, M Chakravarthy, RS Abhayawardana, JJ Gingell | | 2016 |