Luke R.G. Pike
Luke R.G. Pike
Massachusetts General Hospital
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Regulation of autophagy by ATF4 in response to severe hypoxia
T Rzymski, M Milani, L Pike, F Buffa, HR Mellor, L Winchester, I Pires, ...
Oncogene 29 (31), 4424-4435, 2010
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib
M Milani, T Rzymski, HR Mellor, L Pike, A Bottini, D Generali, AL Harris
Cancer research 69 (10), 4415-4423, 2009
The histone demethylase JMJD2B is regulated by estrogen receptor α and hypoxia, and is a key mediator of estrogen induced growth
J Yang, AM Jubb, L Pike, FM Buffa, H Turley, D Baban, R Leek, KC Gatter, ...
Cancer research 70 (16), 6456-6466, 2010
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells
K Phadwal, J Alegre-Abarrategui, AS Watson, L Pike, S Anbalagan, ...
Autophagy 8 (4), 677-689, 2012
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
LRG Pike, DC Singleton, F Buffa, O Abramczyk, K Phadwal, JL Li, ...
Biochemical Journal 449 (2), 389-400, 2013
Multicenter evaluation of the tolerability of combined treatment with PD-1 and CTLA-4 immune checkpoint inhibitors and palliative radiation therapy
A Bang, TJ Wilhite, LRG Pike, DN Cagney, AA Aizer, A Taylor, A Spektor, ...
International Journal of Radiation Oncology* Biology* Physics 98 (2), 344-351, 2017
Safety of combining radiotherapy with immune-checkpoint inhibition
WL Hwang, LRG Pike, TJ Royce, BA Mahal, JS Loeffler
Nature reviews Clinical oncology 15 (8), 477, 2018
The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
T Rzymski, A Petry, D Kračun, F Riess, L Pike, AL Harris, A Görlach
Oncogene 31 (31), 3621-3634, 2012
Radiation and PD-1 inhibition: favorable outcomes after brain-directed radiation
LRG Pike, A Bang, P Ott, T Balboni, A Taylor, P Catalano, B Rawal, ...
Radiotherapy and Oncology 124 (1), 98-103, 2017
The impact of radiation therapy on lymphocyte count and survival in metastatic cancer patients receiving PD-1 immune checkpoint inhibitors
LRG Pike, A Bang, BA Mahal, A Taylor, M Krishnan, A Spektor, ...
International Journal of Radiation Oncology* Biology* Physics 103 (1), 142-151, 2019
ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia
LRG Pike, K Phadwal, AK Simon, AL Harris
Molecular biology reports 39 (12), 10811-10822, 2012
YU238259 is a novel inhibitor of homology-dependent DNA repair that exhibits synthetic lethality and radiosensitization in repair-deficient tumors
GC Stachelek, E Peterson-Roth, Y Liu, RJ Fernandez, LRG Pike, JM Qian, ...
Molecular Cancer Research 13 (10), 1389-1397, 2015
The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK
JM Croke, LRG Pike, DJ MacPhee
Reproductive Biology and Endocrinology 5 (1), 1-12, 2007
Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database
AR Mahal, S Butler, I Franco, V Muralidhar, D Larios, LRG Pike, SG Zhao, ...
Cancer 125 (19), 3338-3346, 2019
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
C Ager, M Reilley, C Nicholas, T Bartkowiak, A Jaiswal, M Curran, ...
Journal for ImmunoTherapy of Cancer 4 (1), 73, 2016
First Aid for the Basic Sciences, General Principles
T Le, W Hwang, L Pike
McGraw Hill Professional, 2017
Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status
LRG Pike, TJ Royce, AR Mahal, DW Kim, WL Hwang, BA Mahal, ...
Journal of the National Comprehensive Cancer Network 18 (2), 177-184, 2020
HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx
LRG Pike, WL Hwang, TJ Royce, NN Sanford, BA Mahal
Oral oncology 86, 69-74, 2018
Trimodality therapy for HPV-positive oropharyngeal cancer: A population-based study: Trimodality therapy for HPV+ OPC
NN Sanford, WL Hwang, LRG Pike, AC Lam, TJ Royce, BA Mahal
Oral oncology 98, 28-34, 2019
Time to Prostate-specific Antigen Nadir and the Risk of Death From Prostate Cancer Following Radiation and Androgen Deprivation Therapy
LRG Pike, J Wu, MH Chen, M Loffredo, AA Renshaw, J Pfail, PW Kantoff, ...
Urology 126, 145-151, 2019
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