| Hypoxia requires notch signaling to maintain the undifferentiated cell state MV Gustafsson, X Zheng, T Pereira, K Gradin, S Jin, J Lundkvist, JL Ruas, ... Developmental cell 9 (5), 617-628, 2005 | 1361 | 2005 |
| HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α Z Arany, SY Foo, Y Ma, JL Ruas, A Bommi-Reddy, G Girnun, M Cooper, ... Nature 451 (7181), 1008-1012, 2008 | 1295 | 2008 |
| Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health I Cervenka, LZ Agudelo, JL Ruas Science 357 (6349), eaaf9794, 2017 | 1134 | 2017 |
| Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5 JH Choi, AS Banks, JL Estall, S Kajimura, P Boström, D Laznik, JL Ruas, ... Nature 466 (7305), 451-456, 2010 | 1026 | 2010 |
| Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis RR Rao, JZ Long, JP White, KJ Svensson, J Lou, I Lokurkar, ... Cell 157 (6), 1279-1291, 2014 | 966 | 2014 |
| Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression LZ Agudelo, T Femenía, F Orhan, M Porsmyr-Palmertz, M Goiny, ... Cell 159 (1), 33-45, 2014 | 836 | 2014 |
| A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy JL Ruas, JP White, RR Rao, S Kleiner, KT Brannan, BC Harrison, ... Cell 151 (6), 1319-1331, 2012 | 815 | 2012 |
| Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex S Kajimura, P Seale, T Tomaru, H Erdjument-Bromage, MP Cooper, ... Genes & development 22 (10), 1397-1409, 2008 | 605 | 2008 |
| The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle J Chinsomboon, J Ruas, RK Gupta, R Thom, J Shoag, GC Rowe, ... Proceedings of the national academy of sciences 106 (50), 21401-21406, 2009 | 501 | 2009 |
| The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex J Wu, JL Ruas, JL Estall, KA Rasbach, JH Choi, L Ye, P Boström, HM Tyra, ... Cell metabolism 13 (2), 160-169, 2011 | 381 | 2011 |
| Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways X Zheng, S Linke, JM Dias, X Zheng, K Gradin, TP Wallis, BR Hamilton, ... Proceedings of the National Academy of Sciences 105 (9), 3368-3373, 2008 | 313 | 2008 |
| Kynurenic acid and Gpr35 regulate adipose tissue energy homeostasis and inflammation LZ Agudelo, DMS Ferreira, I Cervenka, G Bryzgalova, S Dadvar, ... Cell metabolism 27 (2), 378-392. e5, 2018 | 262 | 2018 |
| Hypoxia inducible factor regulates the cardiac expression and secretion of apelin VP Ronkainen, JJ Ronkainen, SL Hänninen, H Leskinen, JL Ruas, ... The FASEB Journal 21 (8), 1821-1830, 2007 | 239 | 2007 |
| The hitchhiker’s guide to PGC-1α isoform structure and biological functions V Martínez-Redondo, AT Pettersson, JL Ruas Diabetologia 58, 1969-1977, 2015 | 231 | 2015 |
| Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise N Place, N Ivarsson, T Venckunas, D Neyroud, M Brazaitis, AJ Cheng, ... Proceedings of the National Academy of Sciences 112 (50), 15492-15497, 2015 | 215 | 2015 |
| PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types KA Rasbach, RK Gupta, JL Ruas, J Wu, E Naseri, JL Estall, ... Proceedings of the National Academy of Sciences 107 (50), 21866-21871, 2010 | 191 | 2010 |
| Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans M Schlittler, M Goiny, LZ Agudelo, T Venckunas, M Brazaitis, A Skurvydas, ... American Journal of Physiology-Cell Physiology 310 (10), C836-C840, 2016 | 190 | 2016 |
| Functional analysis of hypoxia-inducible factor-1α-mediated transactivation: identification of amino acid residues critical for transcriptional activation and/or interaction … JL Ruas, L Poellinger, T Pereira Journal of Biological Chemistry 277 (41), 38723-38730, 2002 | 186 | 2002 |
| PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis JL Estall, JL Ruas, CS Choi, D Laznik, M Badman, E Maratos-Flier, ... Proceedings of the National Academy of Sciences 106 (52), 22510-22515, 2009 | 179 | 2009 |
| Role of CBP in regulating HIF-1-mediated activation of transcription JL Ruas, L Poellinger, T Pereira Journal of cell science 118 (2), 301-311, 2005 | 147 | 2005 |
Bruce M. SpiegelmanStanley J. Korsmeyer Professor, Harvard Medical School and Dana-Farber Cancer InstituteVerified email at dfci.harvard.edu
