Lorna Hale
Lorna Hale
Lab Head: Nephrology
Verified email at novartis.com
Cited by
Cited by
Insulin signaling to the glomerular podocyte is critical for normal kidney function
GI Welsh, LJ Hale, V Eremina, M Jeansson, Y Maezawa, R Lennon, ...
Cell metabolism 12 (4), 329-340, 2010
Evaluation of variability in human kidney organoids
B Phipson, P X. Er, AN Combes, TA Forbes, SE Howden, L Zappia, ...
Nature Methods, 2018
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms
T Forbes, S Howden, K Lawlor, B Phipson, L Hale, S Wilson, C Quinlan, ...
The American Journal of Human Genetics, 2018
Insulin-like growth factors and kidney disease
LA Bach, LJ Hale
American Journal of Kidney Diseases 65 (2), 327-336, 2015
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
LJ Hale, SE Howden, B Phipson, A Lonsdale, P X.Er, I Ghobrial, S Hosawi, ...
Nature Communications 9 (Article number: 5167), 2018
Insulin directly stimulates VEGF-A production in the glomerular podocyte
LJ Hale, J Hurcombe, A Lay, B Santamaría, AM Valverde, MA Saleem, ...
American journal of physiology-Renal physiology 305 (2), F182-F188, 2013
Insulin signalling to the kidney in health and disease
LJ Hale, RJM Coward
Clinical science 124 (6), 351-370, 2013
The insulin receptor and the kidney
LJ Hale, RJM Coward
Current opinion in nephrology and hypertension 22 (1), 100-106, 2013
IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes
B Santamaria, E Marquez, A Lay, RMM Carew, Á González-Rodríguez, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (12), 3224-3234, 2015
Insulin‐like growth factor‐II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse
LJ Hale, GI Welsh, CM Perks, JA Hurcombe, S Moore, I Hers, MA Saleem, ...
The Journal of pathology 230 (1), 95-106, 2013
Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury
Z Chai, A Dai, Y Tu, J Li, T Wu, Y Wang, LJ Hale, F Koentgen, MC Thomas, ...
Journal of the American Society of Nephrology 24 (11), 1782-1792, 2013
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
KT Lawlor, JM Vanslambrouck, JW Higgins, A Chambon, K Bishard, ...
Nature Biomaterials 63, 2020
Generating Kidney from Stem Cells
MH Little, LJ Hale, SE Howden, SV Kumar
Annual Review of Physiology 81, 335–357, 2019
Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening
JW Higgins, A Chambon, K Bishard, A Hartung, D Arndt, J Brugnano, ...
bioRxiv, 505396, 2018
Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells
B Phipson, XE Pei, L Hale, D Yen, K Lawlor, M Takasato, J Sun, ...
bioRxiv, 238428, 2017
IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes
AC Lay, LJ Hale, H Stowell-Connolly, RJP Pope, V Nair, W Ju, E Marquez, ...
Diabetologia, 2021
Shining a Light on Alport Syndrome
L Hale, M Little
Cell Chemical Biology 25 (5), 497-498, 2018
Optimisation of Kidney Organoids as a Reproducible and Developmentally Accurate Model of Human Kidney Development and Disease
MH Little, PX Er, B Phipson, J Vanslambrouck, S Howden, L Hale, ...
Journal of Gene Medicine 20 (1), 2018
Corrigendum to “IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes”[Biochim. Biophys. Acta 1853 (12)(2015) 3224–3234]
B Santamaria, E Marquez, A Lay, RMM Carew, Á González-Rodríguez, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 4 (1863), 786, 2016
The roles of insulin and insulin-like growth factors in the podocyte cells of the kidney
LJ Hale
University of Bristol, 2011
The system can't perform the operation now. Try again later.
Articles 1–20