Roberto Cappai
Roberto Cappai
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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
JA Duce, A Tsatsanis, MA Cater, SA James, E Robb, K Wikhe, SL Leong, ...
Cell 142 (6), 857-867, 2010
The redox chemistry of the Alzheimer's disease amyloid β peptide
DG Smith, R Cappai, KJ Barnham
Biochimica et Biophysica Acta (BBA)-Biomembranes 1768 (8), 1976-1990, 2007
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ
PA Adlard, RA Cherny, DI Finkelstein, E Gautier, E Robb, M Cortes, ...
Neuron 59 (1), 43-55, 2008
Metalloenzyme-like activity of Alzheimer's disease β-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
C Opazo, X Huang, RA Cherny, RD Moir, AE Roher, AR White, R Cappai, ...
Journal of Biological Chemistry 277 (43), 40302-40308, 2002
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
OM Andersen, J Reiche, V Schmidt, M Gotthardt, R Spoelgen, J Behlke, ...
Proceedings of the National Academy of Sciences 102 (38), 13461-13466, 2005
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
P Lei, S Ayton, DI Finkelstein, L Spoerri, GD Ciccotosto, DK Wright, ...
Nature medicine 18 (2), 291-295, 2012
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
QZ Tuo, P Lei, KA Jackman, XL Li, H Xiong, ZY Liuyang, L Roisman, ...
Molecular psychiatry 22 (11), 1520-1530, 2017
Packaging of prions into exosomes is associated with a novel pathway of PrP processing
LJ Vella, RA Sharples, VA Lawson, CL Masters, R Cappai, AF Hill
The Journal of Pathology: A Journal of the Pathological Society of Great …, 2007
Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
CJ Maynard, R Cappai, I Volitakis, RA Cherny, AR White, K Beyreuther, ...
Journal of Biological Chemistry 277 (47), 44670-44676, 2002
Metals and amyloid‐β in Alzheimer's disease
CJ Maynard, AI Bush, CL Masters, R Cappai, QX Li
International journal of experimental pathology 86 (3), 147-159, 2005
18F-THK523: a novel in vivo tau imaging ligand for Alzheimer’s disease
MT Fodero-Tavoletti, N Okamura, S Furumoto, RS Mulligan, AR Connor, ...
Brain 134 (4), 1089-1100, 2011
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-β1-42
PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, ...
Journal of Neuroscience 25 (3), 672-679, 2005
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain: a regulator of neuronal copper homeostasis
KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, ...
Journal of Biological Chemistry 278 (19), 17401-17407, 2003
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
AR White, R Reyes, JFB Mercer, J Camakaris, H Zheng, AI Bush, ...
Brain research 842 (2), 439-444, 1999
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
J Rossjohn, R Cappai, SC Feil, A Henry, WJ McKinstry, D Galatis, ...
Nature structural biology 6 (4), 327-331, 1999
Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway
R Cappai, SL Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, ...
The FASEB journal 19 (10), 1377-1379, 2005
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106− 126
MF Jobling, X Huang, LR Stewart, KJ Barnham, C Curtain, I Volitakis, ...
Biochemistry 40 (27), 8073-8084, 2001
Homocysteine potentiates copper‐and amyloid beta peptide‐mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's‐type neurodegenerative pathways
AR White, X Huang, MF Jobling, CJ Barrow, K Beyreuther, CL Masters, ...
Journal of neurochemistry 76 (5), 1509-1520, 2001
Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
PJ Crouch, LW Hung, PA Adlard, M Cortes, V Lal, G Filiz, KA Perez, ...
Proceedings of the National Academy of Sciences 106 (2), 381-386, 2009
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid
KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, C Mavros, ...
The FASEB Journal 18 (12), 1427-1429, 2004
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