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Lauren E. Boucher
Lauren E. Boucher
Verified email at abbvie.com
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Open source drug discovery with the malaria box compound collection for neglected diseases and beyond
WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ...
PLoS pathogens 12 (7), e1005763, 2016
2942016
The apicomplexan glideosome and adhesins–structures and function
LE Boucher, J Bosch
Journal of structural biology 190 (2), 93-114, 2015
1212015
DXP Synthase‐Catalyzed C-N Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design
F Morris, R Vierling, L Boucher, J Bosch, CL Freel Meyers
ChemBioChem 14 (11), 1309-1315, 2013
402013
Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum
K Reiter, D Mukhopadhyay, H Zhang, LE Boucher, N Kumar, J Bosch, ...
Journal of Biological Chemistry 288 (39), 27724-27736, 2013
322013
Development of a multifunctional tool for drug screening against Plasmodial protein–protein interactions via surface plasmon resonance
LE Boucher, J Bosch
Journal of Molecular Recognition 26 (10), 496-500, 2013
242013
Structure of Chlamydomonas reinhardtii THB1, a group 1 truncated hemoglobin with a rare histidine–lysine heme ligation
SL Rice, LE Boucher, JL Schlessman, MR Preimesberger, J Bosch, ...
Acta Crystallographica Section F: Structural Biology Communications 71 (6 …, 2015
222015
Characterization and structural insights into selective E1-E2 interactions in the human and Plasmodium falciparum SUMO conjugation systems
KH Reiter, A Ramachandran, X Xia, LE Boucher, J Bosch, MJ Matunis
Journal of Biological Chemistry 291 (8), 3860-3870, 2016
192016
The bactofilin cytoskeleton protein BacM of Myxococcus xanthus forms an extended β-sheet structure likely mediated by hydrophobic interactions
DM Zuckerman, LE Boucher, K Xie, H Engelhardt, J Bosch, E Hoiczyk
PloS one 10 (3), e0121074, 2015
182015
Structure of Toxoplasma gondii fructose-1, 6-bisphosphate aldolase
LE Boucher, J Bosch
Acta Crystallographica Section F: Structural Biology Communications 70 (9 …, 2014
132014
Discovery of Plasmodium (M)TRAP–Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion
LE Boucher, CS Hopp, JM Muthinja, F Frischknecht, J Bosch
ACS infectious diseases 4 (4), 620-634, 2018
112018
Surface salt bridges contribute to the extreme thermal stability of an FN3‐like domain from a thermophilic bacterium
L Boucher, S Somani, C Negron, W Ma, S Jacobs, W Chan, T Malia, ...
Proteins: Structure, Function, and Bioinformatics 90 (1), 270-281, 2022
62022
“Stapling” scFv for multispecific biotherapeutics of superior properties
LE Boucher, EG Prinslow, M Feldkamp, F Yi, R Nanjunda, SJ Wu, T Liu, ...
Mabs 15 (1), 2195517, 2023
42023
Glideosome of Apicomplexans as a Drug Target
LE Boucher, J Bosch
Comprehensive Analysis of Parasite Biology: From Metabolism to Drug …, 2016
12016
Targeting protein-protein-interactions for antimalarial drug discovery
LE Boucher, DDC Lopez, AS Miller, SM Stamm, J Bosch
Biophysical Journal 108 (2), 148a, 2015
12015
Conformational Dynamics of Antithrombin III With its Allosteric Activator Heparin
L Boucher, R de La Cruz, S Bock, PL Wintrode
Biophysical Journal 96 (3), 69a, 2009
12009
Materials and methods for improved single chain variable fragments
J Luo, L Boucher, M Feldkamp, M Diem, AA Armstrong, A Teplyakov, ...
US Patent App. 18/461,191, 2024
2024
Materials and methods for improved single chain variable fragments
J Luo, L Boucher, M Feldkamp, M Diem, AA Armstrong, A Teplyakov, ...
US Patent 11,787,875, 2023
2023
مواد وطرق لتحسين أجزاء المتغير أحادي السلسلة
J Luo, C Huang, AA Armstrong, L Boucher, A Teplyakov, M Diem, ...
2023
Materiales y métodos para fragmentos variables de cadena única mejorado
J Luo, L Boucher, M Diem, M Feldkamp, A Teplyakov, AA Armstrong, ...
2022
Materiales y métodos para fragmentos variables de cadena única mejorados
C Huang, J Luo, A Teplyakov, M Diem, M Feldkamp, L Boucher, ...
2022
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