Jan Böttcher
Jan Böttcher
Research Group Leader, Technical University Munich
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NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
JP Böttcher, E Bonavita, P Chakravarty, H Blees, M Cabeza-Cabrerizo, ...
Cell, 2018
Cyclooxygenase-dependent tumor growth through evasion of immunity
S Zelenay, AG Van Der Veen, JP Böttcher, KJ Snelgrove, N Rogers, ...
Cell 162 (6), 1257-1270, 2015
GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+ MHCII+ macrophages and dendritic cells
J Helft, J Böttcher, P Chakravarty, S Zelenay, J Huotari, BU Schraml, ...
Immunity 42 (6), 1197-1211, 2015
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
M Dudek, D Pfister, S Donakonda, P Filpe, A Schneider, M Laschinger, ...
Nature 592 (7854), 444-449, 2021
Functional classification of memory CD8+ T cells by CX3CR1 expression
JP Böttcher, M Beyer, F Meissner, Z Abdullah, J Sander, B Höchst, ...
Nature communications 6 (1), 8306, 2015
The role of type 1 conventional dendritic cells in cancer immunity
JP Böttcher, C Reis e Sousa
Trends in Cancer, 2018
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
M Beyer, Y Thabet, RU Müller, T Sadlon, S Classen, K Lahl, S Basu, ...
Nature immunology 12 (9), 898-907, 2011
RIG‐I detects infection with live Listeria by sensing secreted bacterial nucleic acids
Z Abdullah, M Schlee, S Roth, MA Mraheil, W Barchet, J Böttcher, T Hain, ...
The EMBO journal 31 (21), 4153-4164, 2012
Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells
A Schurich, M Berg, D Stabenow, J Böttcher, M Kern, HJ Schild, C Kurts, ...
The Journal of Immunology 184 (8), 4107-4114, 2010
IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function
JP Böttcher, O Schanz, C Garbers, A Zaremba, S Hegenbarth, C Kurts, ...
Cell reports 8 (5), 1318-1327, 2014
Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity
JP Böttcher, O Schanz, D Wohlleber, Z Abdullah, S Debey-Pascher, ...
Cell reports 3 (3), 779-795, 2013
Distinct kinetics and dynamics of cross‐presentation in liver sinusoidal endothelial cells compared to dendritic cells
A Schurich, JP Böttcher, S Burgdorf, P Penzler, S Hegenbarth, M Kern, ...
Hepatology 50 (3), 909-919, 2009
Mechanisms balancing tolerance and immunity in the liver
JP Böttcher, PA Knolle, D Stabenow
Dig Dis 29, 384-390, 2011
Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice
B Höchst, FA Schildberg, J Böttcher, C Metzger, S Huss, A Türler, ...
Hepatology 56 (5), 1924-1933, 2012
Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics
JCR Simon Zenke, Margriet M. Palm, Julia Braun, Alina Gavrilov, Philippa ...
Immunity, 2020
TIMP1 triggers neutrophil extracellular trap formation in pancreatic cancer
B Schoeps, C Eckfeld, O Prokopchuk, J Böttcher, D Häußler, K Steiger, ...
Cancer Research 81 (13), 3568-3579, 2021
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection
S Flommersfeld, JP Böttcher, J Ersching, M Flossdorf, P Meiser, ...
Immunity 54 (10), 2288-2304. e7, 2021
NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity
N Kirchhammer, MP Trefny, M Natoli, D Brücher, SN Smith, F Werner, ...
Science Translational Medicine 14 (653), eabm9043, 2022
Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens
O Schulz, P Hanč, JP Böttcher, R Hoogeboom, D Sandra S., T Pavel, ...
Cell Reports, 2018
Alive but confused: heterogeneity of CD11c+ MHC class II+ cells in GM-CSF mouse bone marrow cultures
J Helft, JP Böttcher, P Chakravarty, S Zelenay, J Huotari, BU Schraml, ...
Immunity 44 (1), 3-4, 2016
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