How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop D Kirkland, S Pfuhler, D Tweats, M Aardema, R Corvi, F Darroudi, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 628 (1 …, 2007 | 474 | 2007 |
CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans AR Boobis, AM Lynch, S Murray, R de la Torre, A Solans, M Farré, ... Cancer research 54 (1), 89-94, 1994 | 322 | 1994 |
Site-specific mutagenesis: retrospective and prospective B Singer Carcinogenesis 12, 949-955, 1991 | 238 | 1991 |
The in vivo Pig-a assay: a report of the International Workshop on Genotoxicity Testing (IWGT) Workgroup BB Gollapudi, AM Lynch, RH Heflich, SD Dertinger, VN Dobrovolsky, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 783, 23-35, 2015 | 155 | 2015 |
Early events in the mammalian response to DNA double-strand breaks LC Riches, AM Lynch, NJ Gooderham Mutagenesis 23 (5), 331-339, 2008 | 143 | 2008 |
Intra-and interindividual variability in systemic exposure in humans to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine … AM Lynch, MG Knize, AR Boobis, NJ Gooderham, DS Davies, S Murray Cancer Research 52 (22), 6216-6223, 1992 | 135 | 1992 |
Quantification of the carcinogens 2-amino-3, 8-dimethyl-and 2-amino-3, 4, 8-trimethylimidazo [4, 5-f] quinoxaline and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine in food … S Murray, AM Lynch, MG Knize, NJ Gooderham Journal of Chromatography B: Biomedical Sciences and Applications 616 (2 …, 1993 | 131 | 1993 |
Genotoxicity screening via the γH2AX by flow assay DJ Smart, KP Ahmedi, JS Harvey, AM Lynch Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 715 (1 …, 2011 | 125 | 2011 |
Investigations into the concept of a threshold for topoisomerase inhibitor‐induced clastogenicity A Lynch, J Harvey, M Aylott, E Nicholas, M Burman, A Siddiqui, S Walker, ... Mutagenesis 18 (4), 345-353, 2003 | 116 | 2003 |
New and emerging technologies for genetic toxicity testing AM Lynch, JC Sasaki, R Elespuru, D Jacobson‐Kram, V Thybaud, ... Environmental and molecular mutagenesis 52 (3), 205-223, 2011 | 113 | 2011 |
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I … D Kirkland, E Zeiger, F Madia, N Gooderham, P Kasper, A Lynch, T Morita, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 775, 55-68, 2014 | 111 | 2014 |
Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay SM Bryce, SL Avlasevich, JC Bemis, M Lukamowicz, A Elhajouji, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 650 (2 …, 2008 | 107 | 2008 |
The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing–The report of an ECVAM–EFPIA workshop M Ceridono, P Tellner, D Bauer, J Barroso, N Alépée, R Corvi, ... Regulatory Toxicology and Pharmacology 63 (3), 480-488, 2012 | 99 | 2012 |
Assessing human risk to heterocyclic amines NJ Gooderham, S Murray, AM Lynch, M Yadollahi-Farsani, K Zhao, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997 | 92 | 1997 |
The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens AM Lynch, JM Parry Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 287 (1 …, 1993 | 92 | 1993 |
Food-derived heterocyclic amine mutagens: variable metabolism and significance to humans NJ Gooderham, S Murray, AM Lynch, M Yadollahi-Farsani, K Zhao, ... Drug metabolism and disposition 29 (4), 529-534, 2001 | 87 | 2001 |
Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial V Meininger, A Genge, LH van den Berg, W Robberecht, A Ludolph, ... The Lancet Neurology 16 (3), 208-216, 2017 | 80 | 2017 |
Flow cytometric enumeration of micronucleated reticulocytes: high transferability among 14 laboratories DK Torous, NE Hall, SD Dertinger, MS Diehl, AH Illi‐Love, K Cederbrant, ... Environmental and molecular mutagenesis 38 (1), 59-68, 2001 | 79 | 2001 |
International Pig‐a gene mutation assay trial: Evaluation of transferability across 14 laboratories SD Dertinger, S Phonethepswath, P Weller, J Nicolette, J Murray, ... Environmental and molecular mutagenesis 52 (9), 690-698, 2011 | 77 | 2011 |
Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future S Avlasevich, S Bryce, M De Boeck, A Elhajouji, F Van Goethem, A Lynch, ... Mutagenesis 26 (1), 147-152, 2011 | 72 | 2011 |