Edward Tuddenham
Edward Tuddenham
Emeritus Professor of Haemophilia, University College London
Verified email at ucl.ac.uk
Cited by
Cited by
Adenovirus-associated virus vector–mediated gene transfer in hemophilia B
AC Nathwani, EGD Tuddenham, S Rangarajan, C Rosales, J McIntosh, ...
New England Journal of Medicine 365 (25), 2357-2365, 2011
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
S Rost, A Fregin, V Ivaskevicius, E Conzelmann, K Hörtnagel, HJ Pelz, ...
Nature 427 (6974), 537-541, 2004
Structure of human factor VIII
GA Vehar, B Keyt, D Eaton, H Rodriguez, DP O'Brien, F Rotblat, ...
Nature 312 (5992), 337-342, 1984
The hemophilias—from royal genes to gene therapy
PM Mannucci, EGD Tuddenham
New England Journal of Medicine 344 (23), 1773-1779, 2001
Long-term safety and efficacy of factor IX gene therapy in hemophilia B
AC Nathwani, UM Reiss, EGD Tuddenham, C Rosales, P Chowdary, ...
New England Journal of Medicine 371 (21), 1994-2004, 2014
Expression of active human factor VIII from recombinant DNA clones
WI Wood, DJ Capon, CC Simonsen, DL Eaton, J Gitschier, B Keyt, ...
Nature 312 (5992), 330-337, 1984
Biopsy of human preimplantation embryos and sexing by DNA amplification
AH Handyside, RJA Penketh, RML Winston, JK Pattinson, JDA Delhanty, ...
The Lancet 333 (8634), 347-349, 1989
Postgraduate haematology
AV Hoffbrand, DR Higgs, DM Keeling, AB Mehta
John Wiley & Sons, 2016
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and …
AC Nathwani, JT Gray, CYC Ng, J Zhou, Y Spence, SN Waddington, ...
Blood 107 (7), 2653-2661, 2006
Hoemophilid A: Mutation Type Determines Risk of Inhibitor Formation
R Schwoob, H Brockmonn, C Meyer, J Seehofer, M Kirchgesser, A Hoock, ...
Thromb. Haemost 74 (6), 1402-1406, 1995
Distribution of factor VIII mRNA and antigen in human liver and other tissues
KL Wion, D Kelly, JA Summerfield, EGD Tuddenham, RM Lawn
Nature 317 (6039), 726-729, 1985
Genetic mapping and diagnosis of haemophilia A achieved through a Bcl I polymorphism in the factor VIII gene
J Gitschier, D Drayna, EGD Tuddenham, RL White, RM Lawn
Nature 314 (6013), 738-740, 1985
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex
B Zhang, MA Cunningham, WC Nichols, JA Bernat, U Seligsohn, SW Pipe, ...
Nature genetics 34 (2), 220-225, 2003
High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction
J O’donnell, EGD Tuddenham, R Manning, G Kemball-Cook, D Johnson, ...
Thrombosis and haemostasis 77 (05), 0825-0828, 1997
Crystal structure of the extracellular region of human tissue factor
K Harlos, DMA Martin, DP O'brien, EY Jones, DI Stuart, I Polikarpov, ...
Nature 370 (6491), 662-666, 1994
The factor VIII structure and mutation resource site: HAMSTeRS version 4
G Kemball-Cook, EGD Tuddenham, AI Wacey
Nucleic Acids Research 26 (1), 216-219, 1998
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman …
AC Nathwani, JT Gray, J McIntosh, CYC Ng, J Zhou, Y Spence, ...
Blood 109 (4), 1414-1421, 2007
Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA
NBY Tsui, RA Kadir, KC Chan, C Chi, G Mellars, EG Tuddenham, ...
Blood 117 (13), 3684-3691, 2011
A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin
S Pemberton, P Lindley, V Zaitsev, G Card, EGD Tuddenham, ...
Blood, The Journal of the American Society of Hematology 89 (7), 2413-2421, 1997
Detection and sequence of mutations in the factor VIII gene of haemophiliacs
J Gitschier, WI Wood, EGD Tuddenham, MA Shuman, TM Goralka, ...
Nature 315 (6018), 427-430, 1985
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