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Pathum Weerawarna
Pathum Weerawarna
Assistant Research Professor of Medicine
Verified email at iu.edu
Title
Cited by
Cited by
Year
Antifungal drug discovery: the process and outcomes
R Calderone, N Sun, F Gay-Andrieu, W Groutas, P Weerawarna, ...
Future microbiology 9 (6), 791-805, 2014
1082014
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
SR Mandadapu, PM Weerawarna, MR Gunnam, KR Alliston, ...
Bioorganic & medicinal chemistry letters 22 (14), 4820-4826, 2012
772012
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator …
JI Juncosa, K Takaya, HV Le, MJ Moschitto, PM Weerawarna, ...
Journal of the American Chemical Society 140 (6), 2151-2164, 2018
702018
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure–activity relationships and biochemical, X-ray crystallographic, cell …
AC Galasiti Kankanamalage, Y Kim, PM Weerawarna, RAZ Uy, ...
Journal of medicinal chemistry 58 (7), 3144-3155, 2015
662015
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus
SR Mandadapu, PM Weerawarna, AM Prior, RAZ Uy, S Aravapalli, ...
Bioorganic & medicinal chemistry letters 23 (13), 3709-3712, 2013
592013
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies
PM Weerawarna, Y Kim, ACG Kankanamalage, VC Damalanka, ...
European journal of medicinal chemistry 119, 300-318, 2016
432016
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
VC Damalanka, Y Kim, KR Alliston, PM Weerawarna, ...
Journal of medicinal chemistry 59 (5), 1899-1913, 2016
362016
Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides
Y Kim, ACG Kankanamalage, VC Damalanka, PM Weerawarna, ...
Antiviral research 125, 84-91, 2016
312016
Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors
ACG Kankanamalage, Y Kim, AD Rathnayake, VC Damalanka, ...
European journal of medicinal chemistry 126, 502-516, 2017
262017
A remarkable difference that one fluorine atom confers on the mechanisms of inactivation of human ornithine aminotransferase by two cyclohexene analogues of γ-aminobutyric acid
W Zhu, PF Doubleday, DS Catlin, PM Weerawarna, A Butrin, S Shen, ...
Journal of the American Chemical Society 142 (10), 4892-4903, 2020
212020
Anti-norovirus therapeutics: a patent review (2010-2015)
AC Galasiti Kankanamalage, PM Weerawarna, Y Kim, KO Chang, ...
Expert opinion on therapeutic patents 26 (3), 297-308, 2016
172016
Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine …
W Zhu, PF Doubleday, A Butrin, PM Weerawarna, RD Melani, DS Catlin, ...
Journal of the American Chemical Society 143 (21), 8193-8207, 2021
122021
Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease
AC Galasiti Kankanamalage, PM Weerawarna, AD Rathnayake, Y Kim, ...
Proteins: Structure, Function, and Bioinformatics 87 (7), 579-587, 2019
122019
In Vitro Antibacterial Activity of 4-Phenyl-1-(2-phenyl-allyl) pyridinium bromide: A Novel Class of Pyridinium Based Antibacterial Compounds
RN Jayatissa, RP Perera, CM Hettiarachchi, PM Weerawarna
Indian journal of microbiology 52, 83-87, 2012
92012
Mechanism-based design of 3-amino-4-halocyclopentenecarboxylic acids as inactivators of GABA aminotransferase
S Shen, PF Doubleday, PM Weerawarna, W Zhu, NL Kelleher, ...
ACS Medicinal Chemistry Letters 11 (10), 1949-1955, 2020
72020
Theoretical and mechanistic validation of global kinetic parameters of the inactivation of GABA aminotransferase by OV329 and CPP-115
PM Weerawarna, MJ Moschitto, RB Silverman
ACS chemical biology 16 (4), 615-630, 2021
52021
Expanding the 18F-radiochemical space: synthesis and applications of 1, 1-18F-difluorinated alkenes
M Tredwell
Synlett 30 (12), 1371-1376, 2019
32019
Lyn Kinase Structure, Regulation, and Involvement in Neurodegenerative Diseases: A Mini Review
PM Weerawarna, TI Richardson
Kinases and Phosphatases 1 (1), 23-38, 2023
22023
Main Proteases of Key RNA Viruses, Including Coronavirus, Recognize P2 Residues in the Polyproline Type II Conformation: Harnessing Proline's Unique Conformation for Protease …
P Weerawarna
12023
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis
PM Weerawarna, IT Schiefer, P Soares, S Fox, RI Morimoto, RD Melani, ...
ACS Central Science 10 (1), 87-103, 2023
2023
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