| Reactive compounds and in vitro false positives in HTS GM Rishton Drug discovery today 2 (9), 382-384, 1997 | 506 | 1997 |
| Nonleadlikeness and leadlikeness in biochemical screening GM Rishton Drug discovery today 8 (2), 86-96, 2003 | 499 | 2003 |
| Natural products as a robust source of new drugs and drug leads: past successes and present day issues GM Rishton The American journal of cardiology 101 (10), S43-S49, 2008 | 448 | 2008 |
| Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl EF Nemeth, WH Heaton, M Miller, J Fox, MF Balandrin, BC Van Wagenen, ... Journal of Pharmacology and Experimental Therapeutics 308 (2), 627-635, 2004 | 435 | 2004 |
| Alzheimer's therapeutics targeting amyloid beta 1–42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity NJ Izzo, J Xu, C Zeng, MJ Kirk, K Mozzoni, C Silky, C Rehak, R Yurko, ... PloS one 9 (11), e111899, 2014 | 199 | 2014 |
| Alzheimer's therapeutics targeting amyloid beta 1–42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve … NJ Izzo, A Staniszewski, L To, M Fa, AF Teich, F Saeed, H Wostein, ... PloS one 9 (11), e111898, 2014 | 168 | 2014 |
| A crowdsourcing evaluation of the NIH chemical probes TI Oprea, CG Bologa, S Boyer, RF Curpan, RC Glen, AL Hopkins, ... Nature chemical biology 5 (7), 441-447, 2009 | 139 | 2009 |
| Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of … GM Rishton, DM Retz, PA Tempest, J Novotny, S Kahn, JJS Treanor, ... Journal of medicinal chemistry 43 (12), 2297-2299, 2000 | 108 | 2000 |
| Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard B Poon, JB Jowett, SA Stewart, RW Armstrong, GM Rishton, IS Chen Journal of virology 71 (5), 3961-3971, 1997 | 108 | 1997 |
| Stereocontrolled preparation of tetrahydrofurans from acid-promoted rearrangements of allylic acetals MH Hopkins, LE Overman, GM Rishton Journal of the American Chemical Society 113 (14), 5354-5365, 1991 | 105 | 1991 |
| Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer … GM Rishton, K LaBonte, AJ Williams, K Kassam, E Kolovanov Current opinion in drug discovery & development 9 (3), 303-313, 2006 | 56 | 2006 |
| Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening GM Rishton Current opinion in chemical biology 12 (3), 340-351, 2008 | 55 | 2008 |
| Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification NJ Izzo, CM Yuede, KM LaBarbera, CS Limegrover, C Rehak, R Yurko, ... Alzheimer's & Dementia 17 (8), 1365-1382, 2021 | 51 | 2021 |
| Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations GM Rishton Medicinal Chemistry 1 (5), 519-527, 2005 | 49 | 2005 |
| Acid-catalyzed cyclizations of aromatic diazoacetamides; synthesis of spirodienone lactams, isoquinolinones. and benzazepinones GM Rishton, MA Schwanz Tetrahedron letters 29 (22), 2643-2646, 1988 | 44 | 1988 |
| A “GC-rich” method for mammalian gene expression: A dominant role of non-coding DNA GC content in regulation of mammalian gene expression Q Jia, HT Wu, XJ Zhou, J Gao, W Zhao, JD Aziz, JS Wei, L Hou, S Wu, ... Science China Life Sciences 53, 94-100, 2010 | 32 | 2010 |
| Small molecules that promote neurogenesis in vitro GM Rishton Recent Patents on CNS Drug Discovery (Discontinued) 3 (3), 200-208, 2008 | 31 | 2008 |
| Sigma‐2 receptor antagonists rescue neuronal dysfunction induced by Parkinson’s patient brain‐derived α‐synuclein CS Limegrover, R Yurko, NJ Izzo, KM LaBarbera, C Rehak, G Look, ... Journal of Neuroscience Research 99 (4), 1161-1176, 2021 | 28 | 2021 |
| Substituted indolizine-like compounds and methods of use G Cai, JN Chau, C Dominguez, Y Lu, GM Rishton US Patent 6,921,762, 2005 | 28 | 2005 |
| Substituted heterocyclic compounds and methods of use D Andersen, C Chang, J Falsey, M Frohn, FT Hong, H Liao, L Liu, ... US Patent App. 11/237,513, 2006 | 27 | 2006 |
Larry E. OvermanDistinguished Professor of Chemistry, Emeritus, University of California, IrvineVerified email at uci.edu
