Gilbert Rishton
Gilbert Rishton
Chief Science Officer, Cardax / co-Founder and Chief Chemist, Cognition Therapeutics
Verified email at - Homepage
Cited by
Cited by
Reactive compounds and in vitro false positives in HTS
GM Rishton
Drug discovery today 2 (9), 382-384, 1997
Nonleadlikeness and leadlikeness in biochemical screening
GM Rishton
Drug discovery today 8 (2), 86-96, 2003
Natural products as a robust source of new drugs and drug leads: Past successes and present day issues
GM Rishton
The American journal of cardiology 101 (10), S43-S49, 2008
Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
EF Nemeth, WH Heaton, M Miller, J Fox, MF Balandrin, BC Van Wagenen, ...
Journal of Pharmacology and Experimental Therapeutics 308 (2), 627-635, 2004
A crowdsourcing evaluation of the NIH chemical probes
TI Oprea, CG Bologa, S Boyer, RF Curpan, RC Glen, AL Hopkins, ...
Nature chemical biology 5 (7), 441-447, 2009
Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.
B Poon, JB Jowett, SA Stewart, RW Armstrong, GM Rishton, IS Chen
Journal of virology 71 (5), 3961-3971, 1997
Alzheimer's therapeutics targeting amyloid beta 1–42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity
NJ Izzo, J Xu, C Zeng, MJ Kirk, K Mozzoni, C Silky, C Rehak, R Yurko, ...
PloS one 9 (11), 2014
Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of …
GM Rishton, DM Retz, PA Tempest, J Novotny, S Kahn, JJS Treanor, ...
Journal of medicinal chemistry 43 (12), 2297-2299, 2000
Stereocontrolled preparation of tetrahydrofurans from acid-promoted rearrangements of allylic acetals
MH Hopkins, LE Overman, GM Rishton
Journal of the American Chemical Society 113 (14), 5354-5365, 1991
Alzheimer's therapeutics targeting amyloid beta 1–42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve …
NJ Izzo, A Staniszewski, L To, M Fa, AF Teich, F Saeed, H Wostein, ...
PloS one 9 (11), 2014
Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening
GM Rishton
Current opinion in chemical biology 12 (3), 340-351, 2008
Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer …
GM Rishton, K LaBonte, AJ Williams, K Kassam, E Kolovanov
Current opinion in drug discovery & development 9 (3), 303-313, 2006
Failure and success in modern drug discovery: guiding principles in the establishment of high probability of success drug discovery organizations
GM Rishton
Medicinal Chemistry 1 (5), 519-527, 2005
Acid-catalyzed cyclizations of aromatic diazoacetamides; synthesis of spirodienone lactams, isoquinolinones. and benzazepinones
GM Rishton, MA Schwanz
Tetrahedron letters 29 (22), 2643-2646, 1988
Small molecules that promote neurogenesis in vitro
GM Rishton
Recent patents on CNS drug discovery 3 (3), 200-208, 2008
A single-use, scalable perfusion bioreactor system
L Li, M Shi, Y Song, L Bao, W Yang, X Zhang, M Ruan, G Rishton, A Joudi, ...
BioProcess Int 7 (6), 46-54, 2009
A bioreactor system based on a novel oxygen transfer method
Q Jia, H Li, M Hui, N Hui, A Joudi, G Rishton, L Bao, M Shi, X Zhang, ...
BioProcess International 6 (6), 66, 2008
Substituted heterocyclic compounds and methods of use
D Andersen, C Chang, J Falsey, M Frohn, FT Hong, H Liao, L Liu, ...
US Patent App. 11/237,513, 2006
Aggregator compounds confound amyloid fibrillization assay
GM Rishton
Nature Chemical Biology 4 (3), 159-160, 2008
A “GC-rich” method for mammalian gene expression: A dominant role of non-coding DNA GC content in regulation of mammalian gene expression
Q Jia, HT Wu, XJ Zhou, J Gao, W Zhao, JD Aziz, JS Wei, L Hou, S Wu, ...
Science China Life Sciences 53 (1), 94-100, 2010
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