| PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms J Brognard, E Sierecki, T Gao, AC Newton Molecular cell 25 (6), 917-931, 2007 | 720 | 2007 |
| Mechanism of activation of protein kinase JAK2 by the growth hormone receptor AJ Brooks, W Dai, ML O’Mara, D Abankwa, Y Chhabra, RA Pelekanos, ... Science 344 (6185), 1249783, 2014 | 449 | 2014 |
| Lateral mobility of proteins in liquid membranes revisited Y Gambin, R Lopez-Esparza, M Reffay, E Sierecki, NS Gov, M Genest, ... Proceedings of the National Academy of Sciences 103 (7), 2098-2102, 2006 | 434 | 2006 |
| SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species M Moustaqil, E Ollivier, HP Chiu, S Van Tol, P Rudolffi-Soto, C Stevens, ... Emerging microbes & infections 10 (1), 178-195, 2021 | 221 | 2021 |
| Structural basis of TIR-domain-assembly formation in MAL-and MyD88-dependent TLR4 signaling T Ve, PR Vajjhala, A Hedger, T Croll, F DiMaio, S Horsefield, X Yu, ... Nature structural & molecular biology 24 (9), 743-751, 2017 | 171 | 2017 |
| Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae Y Gambin, N Ariotti, KA McMahon, M Bastiani, E Sierecki, O Kovtun, ... elife 3, e01434, 2014 | 151 | 2014 |
| Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt P Wang, Z Zhou, A Hu, CP de Albuquerque, Y Zhou, L Hong, E Sierecki, ... Molecular cell 54 (3), 378-391, 2014 | 139 | 2014 |
| Thinking outside the bug: molecular targets and strategies to overcome antibiotic resistance A Monserrat-Martinez, Y Gambin, E Sierecki International journal of molecular sciences 20 (6), 1255, 2019 | 110 | 2019 |
| Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential B Meyer, J Chiaravalli, S Gellenoncourt, P Brownridge, DP Bryne, LA Daly, ... Nature Communications 12 (1), 5553, 2021 | 97 | 2021 |
| Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies CLL Pham, N Shanmugam, M Strange, A O'Carroll, JWP Brown, ... EMBO reports 20 (2), e46518, 2019 | 89 | 2019 |
| MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography MTB Clabbers, S Holmes, TW Muusse, PR Vajjhala, SJ Thygesen, ... Nature communications 12 (1), 2578, 2021 | 80 | 2021 |
| Structure of a PSI–LHCI–cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions J Steinbeck, IL Ross, R Rothnagel, P Gäbelein, S Schulze, N Giles, R Ali, ... Proceedings of the National Academy of Sciences 115 (41), 10517-10522, 2018 | 79 | 2018 |
| Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening E Sierecki, W Sinko, JA McCammon, AC Newton Journal of medicinal chemistry 53 (19), 6899-6911, 2010 | 78 | 2010 |
| Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation YJ Chai, E Sierecki, VM Tomatis, RS Gormal, N Giles, IC Morrow, D Xia, ... Journal of Cell Biology 214 (6), 705-718, 2016 | 75 | 2016 |
| Cortactin Scaffolds Arp2/3 and WAVE2 at the Epithelial Zonula Adherens*♦ SP Han, Y Gambin, GA Gomez, S Verma, N Giles, M Michael, SK Wu, ... Journal of Biological Chemistry 289 (11), 7764-7775, 2014 | 72 | 2014 |
| The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 SS Pang, C Bayly-Jones, M Radjainia, BA Spicer, RHP Law, AW Hodel, ... Nature communications 10 (1), 4288, 2019 | 69 | 2019 |
| Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis KA McMahon, Y Wu, Y Gambin, E Sierecki, VA Tillu, T Hall, N Martel, ... Nature communications 10 (1), 3279, 2019 | 62 | 2019 |
| Ultrastructural localisation of protein interactions using conditionally stable nanobodies N Ariotti, J Rae, N Giles, N Martel, E Sierecki, Y Gambin, TE Hall, ... PLoS Biology 16 (4), e2005473, 2018 | 56 | 2018 |
| Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice J Overman, F Fontaine, M Moustaqil, D Mittal, E Sierecki, N Sacilotto, ... Elife 6, e21221, 2017 | 56 | 2017 |
| Single-molecule detection on a portable 3D-printed microscope JWP Brown, A Bauer, ME Polinkovsky, A Bhumkar, DJB Hunter, K Gaus, ... Nature communications 10 (1), 5662, 2019 | 51 | 2019 |
