Emma Sierecki
Emma Sierecki
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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
J Brognard, E Sierecki, T Gao, AC Newton
Molecular cell 25 (6), 917-931, 2007
Lateral mobility of proteins in liquid membranes revisited
Y Gambin, R Lopez-Esparza, M Reffay, E Sierecki, NS Gov, M Genest, ...
Proceedings of the National Academy of Sciences 103 (7), 2098-2102, 2006
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor
AJ Brooks, W Dai, ML O’Mara, D Abankwa, Y Chhabra, RA Pelekanos, ...
Science 344 (6185), 1249783, 2014
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species
M Moustaqil, E Ollivier, HP Chiu, S Van Tol, P Rudolffi-Soto, C Stevens, ...
Emerging microbes & infections 10 (1), 178-195, 2021
Structural basis of TIR-domain-assembly formation in MAL-and MyD88-dependent TLR4 signaling
T Ve, PR Vajjhala, A Hedger, T Croll, F DiMaio, S Horsefield, X Yu, ...
Nature structural & molecular biology 24 (9), 743-751, 2017
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae
Y Gambin, N Ariotti, KA McMahon, M Bastiani, E Sierecki, O Kovtun, ...
elife 3, e01434, 2014
Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt
P Wang, Z Zhou, A Hu, CP de Albuquerque, Y Zhou, L Hong, E Sierecki, ...
Molecular cell 54 (3), 378-391, 2014
Thinking outside the bug: molecular targets and strategies to overcome antibiotic resistance
A Monserrat-Martinez, Y Gambin, E Sierecki
International journal of molecular sciences 20 (6), 1255, 2019
Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies
CLL Pham, N Shanmugam, M Strange, A O'Carroll, JWP Brown, ...
EMBO reports 20 (2), e46518, 2019
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
B Meyer, J Chiaravalli, S Gellenoncourt, P Brownridge, DP Bryne, LA Daly, ...
Nature communications 12 (1), 5553, 2021
Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening
E Sierecki, W Sinko, JA McCammon, AC Newton
Journal of medicinal chemistry 53 (19), 6899-6911, 2010
Cortactin Scaffolds Arp2/3 and WAVE2 at the Epithelial Zonula Adherens*♦
SP Han, Y Gambin, GA Gomez, S Verma, N Giles, M Michael, SK Wu, ...
Journal of Biological Chemistry 289 (11), 7764-7775, 2014
Structure of a PSI–LHCI–cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions
J Steinbeck, IL Ross, R Rothnagel, P Gäbelein, S Schulze, N Giles, R Ali, ...
Proceedings of the National Academy of Sciences 115 (41), 10517-10522, 2018
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation
YJ Chai, E Sierecki, VM Tomatis, RS Gormal, N Giles, IC Morrow, D Xia, ...
Journal of Cell Biology 214 (6), 705-718, 2016
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
SS Pang, C Bayly-Jones, M Radjainia, BA Spicer, RHP Law, AW Hodel, ...
Nature communications 10 (1), 4288, 2019
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MTB Clabbers, S Holmes, TW Muusse, PR Vajjhala, SJ Thygesen, ...
Nature communications 12 (1), 2578, 2021
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis
KA McMahon, Y Wu, Y Gambin, E Sierecki, VA Tillu, T Hall, N Martel, ...
Nature communications 10 (1), 3279, 2019
Cell-free formation and interactome analysis of caveolae
WR Jung, E Sierecki, M Bastiani, A O’Carroll, K Alexandrov, J Rae, ...
Journal of Cell Biology 217 (6), 2141-2165, 2018
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
J Overman, F Fontaine, M Moustaqil, D Mittal, E Sierecki, N Sacilotto, ...
Elife 6, e21221, 2017
Ultrastructural localisation of protein interactions using conditionally stable nanobodies
N Ariotti, J Rae, N Giles, N Martel, E Sierecki, Y Gambin, TE Hall, ...
PLoS Biology 16 (4), e2005473, 2018
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